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    Hif1a hypoxia inducible factor 1 alpha subunit [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29560, updated on 8-Nov-2017
    Official Symbol
    Hif1aprovided by RGD
    Official Full Name
    hypoxia inducible factor 1 alpha subunitprovided by RGD
    Primary source
    RGD:61928
    See related
    Ensembl:ENSRNOG00000008292
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    MOP1
    Summary
    regulates transcription in response to low oxygen; may play a role in vascular biology [RGD, Feb 2006]
    Orthologs
    Location:
    6q24
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (96810868..96856303)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 6 NC_005105.3 (106242409..106287957)

    Chromosome 6 - NC_005105.4Genomic Context describing neighboring genes Neighboring gene protein kinase C, eta Neighboring gene 60S ribosomal protein L7a pseudogene Neighboring gene uncharacterized LOC108351258 Neighboring gene transmembrane protein 183-like Neighboring gene small nuclear RNA activating complex, polypeptide 1 Neighboring gene uncharacterized LOC102550910 Neighboring gene synaptotagmin 16

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    DNA binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    DNA binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    DNA binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    E-box binding IEA
    Inferred from Electronic Annotation
    more info
     
    E-box binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Hsp90 protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    Hsp90 protein binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    RNA polymerase II transcription factor activity, sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    histone acetyltransferase binding IEA
    Inferred from Electronic Annotation
    more info
     
    histone acetyltransferase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    histone acetyltransferase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    histone deacetylase binding IEA
    Inferred from Electronic Annotation
    more info
     
    histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nuclear hormone receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    p53 binding IEA
    Inferred from Electronic Annotation
    more info
     
    p53 binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein heterodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    contributes_to sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    contributes_to transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transcription factor activity, RNA polymerase II transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor activity, RNA polymerase II transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transcription factor activity, transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    B-1 B cell homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    B-1 B cell homeostasis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acute-phase response IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    axonal transport of mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    axonal transport of mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    axonal transport of mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    blood vessel development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    blood vessel morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    camera-type eye morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cardiac ventricle morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    cardiac ventricle morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cartilage development IEA
    Inferred from Electronic Annotation
    more info
     
    cartilage development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular iron ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    cellular iron ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to carbon monoxide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to cobalt ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to cyanide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to electrical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to glucose stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to hydrogen peroxide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to hypoxia ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to insulin stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to interleukin-1 IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to interleukin-1 IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to interleukin-1 ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to light stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to lipid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to nitrite IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to toxic substance IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cerebral cortex development IEA
    Inferred from Electronic Annotation
    more info
     
    cerebral cortex development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    collagen metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    collagen metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    connective tissue replacement involved in inflammatory response wound healing IEA
    Inferred from Electronic Annotation
    more info
     
    connective tissue replacement involved in inflammatory response wound healing ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    digestive tract morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    digestive tract morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    dopaminergic neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    dopaminergic neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    elastin metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    elastin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    embryonic hemopoiesis IEA
    Inferred from Electronic Annotation
    more info
     
    embryonic hemopoiesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    embryonic placenta development IEA
    Inferred from Electronic Annotation
    more info
     
    embryonic placenta development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    epithelial cell differentiation involved in mammary gland alveolus development IEA
    Inferred from Electronic Annotation
    more info
     
    epithelial cell differentiation involved in mammary gland alveolus development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    epithelial to mesenchymal transition IEA
    Inferred from Electronic Annotation
    more info
     
    epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    glucose homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    heart looping IEA
    Inferred from Electronic Annotation
    more info
     
    heart looping ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    hemoglobin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    hemoglobin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    hypoxia-inducible factor-1alpha signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    hypoxia-inducible factor-1alpha signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    intestinal epithelial cell maturation IEA
    Inferred from Electronic Annotation
    more info
     
    intestinal epithelial cell maturation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    iris morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    iris morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    lactate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    lactate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    lactation IEA
    Inferred from Electronic Annotation
    more info
     
    lactation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    maternal process involved in female pregnancy IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    muscle cell cellular homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    muscle cell cellular homeostasis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of TOR signaling IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of bone mineralization IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of bone mineralization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of growth IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of growth ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of mesenchymal cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of mesenchymal cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of ossification ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of reactive oxygen species metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of thymocyte apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of thymocyte apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of vasoconstriction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neural crest cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    neural crest cell migration ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    neural fold elevation formation IEA
    Inferred from Electronic Annotation
    more info
     
    neural fold elevation formation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    outflow tract morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    outflow tract morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    oxygen homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    oxygen homeostasis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of autophagy of mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of autophagy of mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell size IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    positive regulation of epithelial cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of erythrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of gluconeogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of hormone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of hormone biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of macroautophagy IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of macroautophagy ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of neuroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of neuroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of pri-miRNA transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of pri-miRNA transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of receptor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of receptor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of smooth muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter in response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription from RNA polymerase II promoter in response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter in response to hypoxia ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of vascular endothelial growth factor production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of vascular endothelial growth factor production ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of vascular endothelial growth factor production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of vascular endothelial growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of vascular endothelial growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of aerobic respiration IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of aerobic respiration ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of catalytic activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of cellular response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of glycolytic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of glycolytic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of thymocyte apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of transcription from RNA polymerase II promoter in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription from RNA polymerase II promoter in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription from RNA polymerase II promoter in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of transcription, DNA-templated TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of transforming growth factor beta2 production IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transforming growth factor beta2 production ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to X-ray IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to activity IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to alkaloid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to anesthetic IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to auditory stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to cobalt ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to estradiol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to estrogen IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to fungicide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to glucocorticoid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to glucose IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to hypoxia IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to hypoxia ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to iron ion IEA
    Inferred from Electronic Annotation
    more info
     
    response to iron ion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to muscle activity IEA
    Inferred from Electronic Annotation
    more info
     
    response to muscle activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to purine-containing compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to salt stress IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    retina vasculature development in camera-type eye IEA
    Inferred from Electronic Annotation
    more info
     
    retina vasculature development in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    signal transduction ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    vascular endothelial growth factor production IEA
    Inferred from Electronic Annotation
    more info
     
    vascular endothelial growth factor production ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    vasculature development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    visual learning IEA
    Inferred from Electronic Annotation
    more info
     
    visual learning ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    RNA polymerase II transcription factor complex IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II transcription factor complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    motile cilium IEA
    Inferred from Electronic Annotation
    more info
     
    motile cilium ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nuclear speck ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transcription factor complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Preferred Names
    hypoxia-inducible factor 1-alpha
    Names
    HIF-1-alpha
    HIF1-alpha
    hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024359.1NP_077335.1  hypoxia-inducible factor 1-alpha

      See identical proteins and their annotated locations for NP_077335.1

      Status: PROVISIONAL

      Source sequence(s)
      AF057308
      UniProtKB/Swiss-Prot
      O35800
      Related
      ENSRNOP00000070177.1, ENSRNOT00000077935.1
      Conserved Domains (6) summary
      smart00091
      Location:94149
      PAS; PAS domain
      cd00083
      Location:1669
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:240339
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam08447
      Location:255340
      PAS_3; PAS fold
      pfam08778
      Location:786822
      HIF-1a_CTAD; HIF-1 alpha C terminal transactivation domain
      pfam11413
      Location:556580
      HIF-1; Hypoxia-inducible factor-1

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005105.4 Reference Rnor_6.0 Primary Assembly

      Range
      96810868..96856303
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006240196.3XP_006240258.1  hypoxia-inducible factor 1-alpha isoform X1

      Conserved Domains (6) summary
      smart00091
      Location:94149
      PAS; PAS domain
      cd00083
      Location:1669
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:240339
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam08447
      Location:255340
      PAS_3; PAS fold
      pfam08778
      Location:791827
      HIF-1a_CTAD; HIF-1 alpha C terminal transactivation domain
      pfam11413
      Location:556580
      HIF-1; Hypoxia-inducible factor-1
    2. XM_006240197.3XP_006240259.1  hypoxia-inducible factor 1-alpha isoform X2

      Conserved Domains (6) summary
      smart00091
      Location:93148
      PAS; PAS domain
      cd00083
      Location:1568
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:239338
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam08447
      Location:254339
      PAS_3; PAS fold
      pfam08778
      Location:790826
      HIF-1a_CTAD; HIF-1 alpha C terminal transactivation domain
      pfam11413
      Location:555579
      HIF-1; Hypoxia-inducible factor-1
    3. XM_006240198.3XP_006240260.1  hypoxia-inducible factor 1-alpha isoform X3

      UniProtKB/TrEMBL
      D4A8P8
      Related
      ENSRNOP00000042230.3, ENSRNOT00000049725.3
      Conserved Domains (6) summary
      smart00091
      Location:93148
      PAS; PAS domain
      cd00083
      Location:1568
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:239338
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam08447
      Location:254339
      PAS_3; PAS fold
      pfam08778
      Location:788824
      HIF-1a_CTAD; HIF-1 alpha C terminal transactivation domain
      pfam11413
      Location:555579
      HIF-1; Hypoxia-inducible factor-1
    4. XM_006240199.3XP_006240261.1  hypoxia-inducible factor 1-alpha isoform X4

      See identical proteins and their annotated locations for XP_006240261.1

      Conserved Domains (6) summary
      smart00091
      Location:81136
      PAS; PAS domain
      cd00083
      Location:356
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:227326
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam08447
      Location:242327
      PAS_3; PAS fold
      pfam08778
      Location:778814
      HIF-1a_CTAD; HIF-1 alpha C terminal transactivation domain
      pfam11413
      Location:543567
      HIF-1; Hypoxia-inducible factor-1

    Alternate Rn_Celera

    Genomic

    1. AC_000074.1 Alternate Rn_Celera

      Range
      91083300..91128125
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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