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    Axin2 axin 2 [ Mus musculus (house mouse) ]

    Gene ID: 12006, updated on 13-Jun-2017
    Official Symbol
    Axin2provided by MGI
    Official Full Name
    axin 2provided by MGI
    Primary source
    MGI:MGI:1270862
    See related
    Ensembl:ENSMUSG00000000142 Vega:OTTMUSG00000003199
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Axi1; Axil; Conductin
    Orthologs
    Location:
    11 E1; 11 71.83 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (108917828..108950783)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (108781663..108812097)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene centrosomal protein 112 Neighboring gene predicted gene, 36818 Neighboring gene predicted gene, 46298 Neighboring gene predicted gene, 36876 Neighboring gene RIKEN cDNA E030025P04 gene

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Basal cell carcinoma, organism-specific biosystem (from KEGG)
      Basal cell carcinoma, organism-specific biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
    • Basal cell carcinoma, conserved biosystem (from KEGG)
      Basal cell carcinoma, conserved biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
    • Breast cancer, organism-specific biosystem (from KEGG)
      Breast cancer, organism-specific biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
    • Breast cancer, conserved biosystem (from KEGG)
      Breast cancer, conserved biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
    • Colorectal cancer, organism-specific biosystem (from KEGG)
      Colorectal cancer, organism-specific biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
    • Colorectal cancer, conserved biosystem (from KEGG)
      Colorectal cancer, conserved biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
    • Degradation of AXIN, organism-specific biosystem (from REACTOME)
      Degradation of AXIN, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Deubiquitination, organism-specific biosystem (from REACTOME)
      Deubiquitination, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Endometrial cancer, organism-specific biosystem (from KEGG)
      Endometrial cancer, organism-specific biosystemEndometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endom...
    • Endometrial cancer, conserved biosystem (from KEGG)
      Endometrial cancer, conserved biosystemEndometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endom...
    • Hippo signaling pathway, organism-specific biosystem (from KEGG)
      Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
    • Hippo signaling pathway, conserved biosystem (from KEGG)
      Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Post-translational protein modification, organism-specific biosystem (from REACTOME)
      Post-translational protein modification, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Signaling by Wnt, organism-specific biosystem (from REACTOME)
      Signaling by Wnt, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Signaling pathways regulating pluripotency of stem cells, organism-specific biosystem (from KEGG)
      Signaling pathways regulating pluripotency of stem cells, organism-specific biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
    • Signaling pathways regulating pluripotency of stem cells, conserved biosystem (from KEGG)
      Signaling pathways regulating pluripotency of stem cells, conserved biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
    • TCF dependent signaling in response to WNT, organism-specific biosystem (from REACTOME)
      TCF dependent signaling in response to WNT, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Ub-specific processing proteases, organism-specific biosystem (from REACTOME)
      Ub-specific processing proteases, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Wnt Signaling Pathway NetPath, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway NetPath, organism-specific biosystemWnt family of proteins are a large family of cysteine-rich secreted glycoproteins that regulate cell-cell interactions. They bind to members of the Frizzled family of 7 transmembrane receptors. Bindi...
    • Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell pluri...
    • Wnt signaling pathway, organism-specific biosystem (from KEGG)
      Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt signaling pathway, conserved biosystem (from KEGG)
      Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    I-SMAD binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    bone mineralization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell death ISO
    Inferred from Sequence Orthology
    more info
     
    cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    chondrocyte differentiation involved in endochondral bone morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intramembranous ossification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    maintenance of DNA repeat elements ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of catenin import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    odontogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of centromeric sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of centromeric sister chromatid cohesion ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of chondrocyte development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of mismatch repair ISO
    Inferred from Sequence Orthology
    more info
     
    secondary heart field specification IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    somitogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    axin-2
    Names
    axin-like protein
    axis inhibition protein 2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015732.4NP_056547.3  axin-2

      See identical proteins and their annotated locations for NP_056547.3

      Status: VALIDATED

      Source sequence(s)
      AK142333, BC057338
      Consensus CDS
      CCDS25575.1
      UniProtKB/Swiss-Prot
      O88566
      UniProtKB/TrEMBL
      Q3UQK5
      Related
      ENSMUSP00000051331.7, OTTMUSP00000003133, ENSMUST00000052915.13, OTTMUST00000006621
      Conserved Domains (4) summary
      cd08707
      Location:82198
      RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
      smart00021
      Location:758840
      DAX; Domain present in Dishevelled and axin
      pfam08833
      Location:432467
      Axin_b-cat_bind; Axin beta-catenin binding domain
      pfam16646
      Location:1073
      AXIN1_TNKS_BD; Axin-1 tankyrase binding domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      108917828..108950783
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532058.1XP_006532121.1  axin-2 isoform X1

      See identical proteins and their annotated locations for XP_006532121.1

      UniProtKB/Swiss-Prot
      O88566
      Conserved Domains (4) summary
      cd08707
      Location:82198
      RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
      smart00021
      Location:758840
      DAX; Domain present in Dishevelled and axin
      pfam08833
      Location:432467
      Axin_b-cat_bind; Axin beta-catenin binding domain
      pfam16646
      Location:1073
      AXIN1_TNKS_BD; Axin-1 tankyrase binding domain
    2. XM_006532057.3XP_006532120.1  axin-2 isoform X1

      See identical proteins and their annotated locations for XP_006532120.1

      UniProtKB/Swiss-Prot
      O88566
      Conserved Domains (4) summary
      cd08707
      Location:82198
      RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
      smart00021
      Location:758840
      DAX; Domain present in Dishevelled and axin
      pfam08833
      Location:432467
      Axin_b-cat_bind; Axin beta-catenin binding domain
      pfam16646
      Location:1073
      AXIN1_TNKS_BD; Axin-1 tankyrase binding domain
    3. XM_006532060.1XP_006532123.1  axin-2 isoform X1

      See identical proteins and their annotated locations for XP_006532123.1

      UniProtKB/Swiss-Prot
      O88566
      Related
      ENSMUSP00000102322.1, OTTMUSP00000003134, ENSMUST00000106711.1, OTTMUST00000006622
      Conserved Domains (4) summary
      cd08707
      Location:82198
      RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
      smart00021
      Location:758840
      DAX; Domain present in Dishevelled and axin
      pfam08833
      Location:432467
      Axin_b-cat_bind; Axin beta-catenin binding domain
      pfam16646
      Location:1073
      AXIN1_TNKS_BD; Axin-1 tankyrase binding domain
    4. XM_006532059.3XP_006532122.1  axin-2 isoform X1

      See identical proteins and their annotated locations for XP_006532122.1

      UniProtKB/Swiss-Prot
      O88566
      Conserved Domains (4) summary
      cd08707
      Location:82198
      RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
      smart00021
      Location:758840
      DAX; Domain present in Dishevelled and axin
      pfam08833
      Location:432467
      Axin_b-cat_bind; Axin beta-catenin binding domain
      pfam16646
      Location:1073
      AXIN1_TNKS_BD; Axin-1 tankyrase binding domain
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