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    THBS1 thrombospondin 1 [ Homo sapiens (human) ]

    Gene ID: 7057, updated on 22-Apr-2017
    Official Symbol
    THBS1provided by HGNC
    Official Full Name
    thrombospondin 1provided by HGNC
    Primary source
    HGNC:HGNC:11785
    See related
    Ensembl:ENSG00000137801 MIM:188060; Vega:OTTHUMG00000133665
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TSP; THBS; TSP1; TSP-1; THBS-1
    Summary
    The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    15q14
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 15 NC_000015.10 (39581079..39598918)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (39873280..39889668)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370783 Neighboring gene uncharacterized LOC105370784 Neighboring gene uncharacterized LOC105370785 Neighboring gene fibrous sheath interacting protein 1 Neighboring gene uncharacterized LOC105370941

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env TSP1 inhibits HIV-1 infection of peripheral blood mononuclear cells and transformed T and promonocytic cell lines by its binding to HIV-1 gp120 PubMed
    env Interaction of TSP1 with HIV-1 gp120 involves CSVTCG sequences in the type 1 properdin-like repeats of TSP1 and amino acids 281-300, 311-330, and 361-380 in the C2-V3-C3 domains of gp120 PubMed
    Tat tat Thrombospondin-1 (TSP) prevents endothelial cell motility induced by HIV-1 Tat and inhibits angiogenic activity exerted by Tat in the Matrigel sponge model, suggesting downregulation of TSP may be permissive for development of KS-associated angiogenesis PubMed
    tat Thrombospondin-1 inhibits cell internalization and HIV-1 LTR transactivating activity of extracellular HIV-1 Tat, cell interaction and mitogenic activity of extracellular Tat, as well as the autocrine loop of stimulation exerted by endogenous Tat PubMed
    tat Thrombospondin-1 (TSP) binds to HIV-1 Tat, an interaction that can be inhibited by heparin which can bind to both TSP and Tat PubMed
    Vpr vpr HIV-1 Vpr potentiates the stimulation of thrombospondin 1 by glucocorticoids via the glucocorticoid receptor pathway PubMed

    Go to the HIV-1, Human Interaction Database

    • Apoptosis-related network due to altered Notch3 in ovarian cancer, organism-specific biosystem (from WikiPathways)
      Apoptosis-related network due to altered Notch3 in ovarian cancer, organism-specific biosystemResults of pathway analysis of apoptosis-related genes in OVCAR3 cells treated with Notch3 siRNA or control siRNA.
    • Bladder Cancer, organism-specific biosystem (from WikiPathways)
      Bladder Cancer, organism-specific biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
    • Bladder cancer, organism-specific biosystem (from KEGG)
      Bladder cancer, organism-specific biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
    • Bladder cancer, conserved biosystem (from KEGG)
      Bladder cancer, conserved biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
    • Defective B3GALTL causes Peters-plus syndrome (PpS), organism-specific biosystem (from REACTOME)
      Defective B3GALTL causes Peters-plus syndrome (PpS), organism-specific biosystemHuman beta-1,3-glucosyltransferase like protein (B3GALTL, HGNC Approved Gene Symbol: B3GLCT; MIM:610308; CAZy family GT31), localised on the ER membrane, glucosylates O-fucosylated proteins. The resu...
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Diseases associated with O-glycosylation of proteins, organism-specific biosystem (from REACTOME)
      Diseases associated with O-glycosylation of proteins, organism-specific biosystemGlycosylation is the most abundant modification of proteins, variations of which occur in all living cells. Glycosylation can be further categorized into N-linked (where the oligosaccharide is conjug...
    • Diseases of glycosylation, organism-specific biosystem (from REACTOME)
      Diseases of glycosylation, organism-specific biosystemDiseases of glycosylation, usually referred to as congenital disorders of glycosylation (CDG), are rare inherited disorders ascribing defects of nucleotide-sugar biosynthesis and transport, glycosylt...
    • ECM-receptor interaction, organism-specific biosystem (from KEGG)
      ECM-receptor interaction, organism-specific biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
    • ECM-receptor interaction, conserved biosystem (from KEGG)
      ECM-receptor interaction, conserved biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
    • Extracellular matrix organization, organism-specific biosystem (from REACTOME)
      Extracellular matrix organization, organism-specific biosystemThe extracellular matrix is a component of all mammalian tissues, a network consisting largely of the fibrous proteins collagen, elastin and associated-microfibrils, fibronectin and laminins embedded...
    • Focal Adhesion, organism-specific biosystem (from WikiPathways)
      Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Inflammatory Response Pathway, organism-specific biosystem (from WikiPathways)
      Inflammatory Response Pathway, organism-specific biosystem
      Inflammatory Response Pathway
    • Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
      Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
    • Integrin cell surface interactions, organism-specific biosystem (from REACTOME)
      Integrin cell surface interactions, organism-specific biosystemThe extracellular matrix (ECM) is a network of macro-molecules that underlies all epithelia and endothelia and that surrounds all connective tissue cells. This matrix provides the mechanical strength...
    • Malaria, organism-specific biosystem (from KEGG)
      Malaria, organism-specific biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
    • Malaria, conserved biosystem (from KEGG)
      Malaria, conserved biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
      MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
    • MicroRNAs in cancer, conserved biosystem (from KEGG)
      MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
    • Non-integrin membrane-ECM interactions, organism-specific biosystem (from REACTOME)
      Non-integrin membrane-ECM interactions, organism-specific biosystemSeveral non-integrin membrane proteins interact with extracellular matrix proteins. Transmembrane proteoglycans may associate with integrins and growth factor receptors to influence their function, o...
    • O-glycosylation of TSR domain-containing proteins, organism-specific biosystem (from REACTOME)
      O-glycosylation of TSR domain-containing proteins, organism-specific biosystemThe O-fucosylation of proteins containing thrombospondin type 1 repeat (TSR) domains is an important PTM, regulating many biological processes such as Notch signalling, inflammation, wound healing, a...
    • O-linked glycosylation, organism-specific biosystem (from REACTOME)
      O-linked glycosylation, organism-specific biosystemO-glycosylation is an important post-translational modification (PTM) required for correct functioning of many proteins (Van den Steen et al. 1998, Moremen et al. 2012). The O-glycosylation of protei...
    • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
      PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
      PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • Phagosome, organism-specific biosystem (from KEGG)
      Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Phagosome, conserved biosystem (from KEGG)
      Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
      Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...
    • Platelet degranulation, organism-specific biosystem (from REACTOME)
      Platelet degranulation, organism-specific biosystemPlatelets function as exocytotic cells, secreting a plethora of effector molecules at sites of vascular injury. Platelets contain a number of distinguishable storage granules including alpha granules...
    • Post-translational protein modification, organism-specific biosystem (from REACTOME)
      Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
    • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
      Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
    • Proteoglycans in cancer, conserved biosystem (from KEGG)
      Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
    • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
      Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
    • Rap1 signaling pathway, conserved biosystem (from KEGG)
      Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
    • Response to elevated platelet cytosolic Ca2+, organism-specific biosystem (from REACTOME)
      Response to elevated platelet cytosolic Ca2+, organism-specific biosystemActivation of phospholipase C enzymes results in the generation of second messengers of the phosphatidylinositol pathway. The events resulting from this pathway are a rise in intracellular calcium an...
    • Senescence and Autophagy in Cancer, organism-specific biosystem (from WikiPathways)
      Senescence and Autophagy in Cancer, organism-specific biosystemSenescense and Autophagy Pathways in Cancer
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by PDGF, organism-specific biosystem (from REACTOME)
      Signaling by PDGF, organism-specific biosystemPlatelet-derived Growth Factor (PDGF) is a potent stimulator of growth and motility of connective tissue cells such as fibroblasts and smooth muscle cells as well as other cells such as capillary end...
    • Syndecan interactions, organism-specific biosystem (from REACTOME)
      Syndecan interactions, organism-specific biosystemSyndecans are type I transmembrane proteins, with an N-terminal ectodomain that contains several consensus sequences for glycosaminoglycan (GAG) attachment and a short C-terminal cytoplasmic domain. ...
    • Syndecan-4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      Syndecan-4-mediated signaling events, organism-specific biosystem
      Syndecan-4-mediated signaling events
    • TGF-beta Receptor Signaling, organism-specific biosystem (from WikiPathways)
      TGF-beta Receptor Signaling, organism-specific biosystemThe Transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiat...
    • TGF-beta Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF-beta Signaling Pathway, organism-specific biosystemThe signal transduction mechanisms underlying the pathophysiological activities of transforming growth factor-? (TGF-?) have been extensively studied since its discovery nearly 30 years ago. TGF-? li...
    • TGF-beta signaling pathway, organism-specific biosystem (from KEGG)
      TGF-beta signaling pathway, organism-specific biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
    • TGF-beta signaling pathway, conserved biosystem (from KEGG)
      TGF-beta signaling pathway, conserved biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
    • miRNA targets in ECM and membrane receptors, organism-specific biosystem (from WikiPathways)
      miRNA targets in ECM and membrane receptors, organism-specific biosystemBased on the KEGG ECM-receptor interactions pathway (hsa04512), a depiction a plausible mechanism, where miRNAs regulate components of both extracellular matrix (top panel) and transmembrane receptor...
    • p53 signaling pathway, organism-specific biosystem (from KEGG)
      p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
    • p53 signaling pathway, conserved biosystem (from KEGG)
      p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calcium ion binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    collagen V binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    fibrinogen binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    fibroblast growth factor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    fibronectin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glycoprotein binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    heparin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    integrin binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    laminin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    low-density lipoprotein particle binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidylserine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    proteoglycan binding TAS
    Traceable Author Statement
    more info
    PubMed 
    transforming growth factor beta binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    transforming growth factor beta binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    activation of MAPK activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    behavioral response to pain ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell adhesion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cell cycle arrest IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to heat NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cellular response to tumor necrosis factor IEA
    Inferred from Electronic Annotation
    more info
     
    chronic inflammatory response IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    engulfment of apoptotic cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular matrix organization TAS
    Traceable Author Statement
    more info
     
    immune response IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    inflammatory response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of blood vessel endothelial cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cGMP-mediated signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cell-matrix adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of dendritic cell antigen processing and presentation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of endothelial cell chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of endothelial cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of endothelial cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of endothelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of extrinsic apoptotic signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of fibrinolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of fibroblast growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of focal adhesion assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of interleukin-12 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of nitric oxide mediated signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of plasma membrane long-chain fatty acid transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of plasminogen activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptide cross-linking IDA
    Inferred from Direct Assay
    more info
    PubMed 
    platelet degranulation TAS
    Traceable Author Statement
    more info
     
    positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of blood coagulation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of blood vessel endothelial cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of endothelial cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of endothelial cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of fibroblast migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of macrophage activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of macrophage chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein kinase B signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of reactive oxygen species metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of smooth muscle cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transforming growth factor beta1 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of tumor necrosis factor biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein O-linked fucosylation TAS
    Traceable Author Statement
    more info
     
    regulation of cGMP metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to calcium ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to endoplasmic reticulum stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to glucose IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to hypoxia NAS
    Non-traceable Author Statement
    more info
    PubMed 
    response to magnesium ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    response to progesterone TAS
    Traceable Author Statement
    more info
    PubMed 
    response to testosterone IEA
    Inferred from Electronic Annotation
    more info
     
    response to unfolded protein IEA
    Inferred from Electronic Annotation
    more info
     
    sprouting angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
     
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with extracellular matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    extracellular matrix TAS
    Traceable Author Statement
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    fibrinogen complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    platelet alpha granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    platelet alpha granule lumen TAS
    Traceable Author Statement
    more info
     
    sarcoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    secretory granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    thrombospondin-1
    Names
    thrombospondin-1p180
    thrombospondin-p50

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003246.3NP_003237.2  thrombospondin-1 precursor

      See identical proteins and their annotated locations for NP_003237.2

      Status: REVIEWED

      Source sequence(s)
      AI147670, AI168683, AK304754, BC015134, BC136470, BG115371, BM512145, BM784452, BU676185, X14787
      Consensus CDS
      CCDS32194.1
      UniProtKB/Swiss-Prot
      P07996
      Related
      ENSP00000260356.5, OTTHUMP00000165029, ENST00000260356.5, OTTHUMT00000257831
      Conserved Domains (10) summary
      smart00209
      Location:438490
      TSP1; Thrombospondin type 1 repeats
      smart00210
      Location:26221
      TSPN; Thrombospondin N-terminal -like domains
      sd00001
      Location:845882
      TSP3; TSP3 repeat_long [structural motif]
      sd00002
      Location:787821
      TSP3; TSP3 repeat_long [structural motif]
      sd00003
      Location:691726
      TSP3_1C; TSP3 repeat_1C [structural motif]
      pfam00090
      Location:383428
      TSP_1; Thrombospondin type 1 domain
      pfam00093
      Location:318372
      VWC; von Willebrand factor type C domain
      pfam02412
      Location:846882
      TSP_3; Thrombospondin type 3 repeat
      pfam05735
      Location:9721169
      TSP_C; Thrombospondin C-terminal region
      pfam12947
      Location:650689
      EGF_3; EGF domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p7 Primary Assembly

      Range
      39581079..39598918
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011521971.1XP_011520273.1  thrombospondin-1 isoform X1

      Conserved Domains (10) summary
      smart00209
      Location:438490
      TSP1; Thrombospondin type 1 repeats
      smart00210
      Location:26221
      TSPN; Thrombospondin N-terminal -like domains
      sd00001
      Location:787824
      TSP3; TSP3 repeat_long [structural motif]
      sd00002
      Location:729763
      TSP3; TSP3 repeat_long [structural motif]
      sd00003
      Location:633668
      TSP3_1C; TSP3 repeat_1C [structural motif]
      pfam00090
      Location:383428
      TSP_1; Thrombospondin type 1 domain
      pfam00093
      Location:318372
      VWC; von Willebrand factor type C domain
      pfam02412
      Location:788824
      TSP_3; Thrombospondin type 3 repeat
      pfam05735
      Location:9141111
      TSP_C; Thrombospondin C-terminal region
      pfam12947
      Location:592631
      EGF_3; EGF domain

    Alternate CHM1_1.1

    Genomic

    1. NC_018926.2 Alternate CHM1_1.1

      Range
      39992660..40010501
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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