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    Smad3 SMAD family member 3 [ Mus musculus (house mouse) ]

    Gene ID: 17127, updated on 23-May-2017
    Official Symbol
    Smad3provided by MGI
    Official Full Name
    SMAD family member 3provided by MGI
    Primary source
    MGI:MGI:1201674
    See related
    Ensembl:ENSMUSG00000032402 Vega:OTTMUSG00000021500
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Madh3; AU022421
    Orthologs
    Location:
    9; 9 C
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (63646766..63757994, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (63494574..63605801, complement)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene IQ motif containing H Neighboring gene predicted gene, 39358 Neighboring gene alpha- and gamma-adaptin binding protein Neighboring gene predicted gene, 35941 Neighboring gene predicted gene, 39359

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DEAD/H-box RNA helicase binding ISO
    Inferred from Sequence Orthology
    more info
     
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    R-SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II activating transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II core promoter proximal region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    bHLH transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    co-SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    collagen binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    core promoter proximal region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    glucocorticoid receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    mineralocorticoid receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    primary miRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor activity, RNA polymerase II core promoter sequence-specific ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to transcription factor activity, protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor activity, sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor activity, sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to transcription factor activity, sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transforming growth factor beta receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    SMAD protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    SMAD protein signal transduction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    T cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    activin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    cell cycle arrest ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell junction organization ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to transforming growth factor beta stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    developmental growth IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    embryonic cranial skeleton morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    embryonic foregut morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    embryonic pattern specification IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    endoderm development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    evasion or tolerance of host defenses by virus ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    gastrulation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    heart looping IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    immune response ISO
    Inferred from Sequence Orthology
    more info
     
    immune system development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    in utero embryonic development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    lens fiber cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    liver development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    mesoderm formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cardiac muscle hypertrophy in response to stress ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of lung blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of osteoblast differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of osteoblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of wound healing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nodal signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    osteoblast development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    paraxial mesoderm morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    pericardium development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of alkaline phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of bone mineralization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of catenin import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of chondrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of extracellular matrix assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-1 beta production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of positive chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of pri-miRNA transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription factor import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transforming growth factor beta3 production ISO
    Inferred from Sequence Orthology
    more info
     
    protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of striated muscle tissue development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transforming growth factor beta2 production ISO
    Inferred from Sequence Orthology
    more info
     
    response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction involved in regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    skeletal system development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    somitogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    thyroid gland development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    transdifferentiation ISO
    Inferred from Sequence Orthology
    more info
     
    transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transforming growth factor beta receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    transport ISO
    Inferred from Sequence Orthology
    more info
     
    ureteric bud development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    SMAD protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    SMAD2-SMAD3 protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    mothers against decapentaplegic homolog 3
    Names
    MAD homolog 3
    Smad 3
    mMad3
    mad3
    mothers against DPP homolog 3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016769.4NP_058049.3  mothers against decapentaplegic homolog 3

      See identical proteins and their annotated locations for NP_058049.3

      Status: VALIDATED

      Source sequence(s)
      AC158515, AK048626, AK083158
      Consensus CDS
      CCDS23272.1
      UniProtKB/Swiss-Prot
      Q8BUN5
      Related
      ENSMUSP00000034973.3, OTTMUSP00000023917, ENSMUST00000034973.9, OTTMUST00000050960
      Conserved Domains (2) summary
      cd10491
      Location:8132
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cd10985
      Location:224414
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      63646766..63757994 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510819.2XP_006510882.2  mothers against decapentaplegic homolog 3 isoform X1

      Conserved Domains (2) summary
      cd10985
      Location:159349
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
      cl00055
      Location:467
      MH1; N-terminal Mad Homology 1 (MH1) domain
    2. XM_006510821.3XP_006510884.1  mothers against decapentaplegic homolog 3 isoform X2

      See identical proteins and their annotated locations for XP_006510884.1

      Conserved Domains (1) summary
      cd10985
      Location:29219
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
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