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    Six1 sine oculis-related homeobox 1 [ Mus musculus (house mouse) ]

    Gene ID: 20471, updated on 4-Sep-2016
    Official Symbol
    Six1provided by MGI
    Official Full Name
    sine oculis-related homeobox 1provided by MGI
    Primary source
    MGI:MGI:102780
    See related
    Ensembl:ENSMUSG00000051367 Vega:OTTMUSG00000040058
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BB138287
    Orthologs
    Location:
    12 C3; 12 30.34 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (73041827..73046712, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (74142814..74147699, complement)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930447C04 gene Neighboring gene sine oculis-related homeobox 6 Neighboring gene sine oculis-related homeobox 4 Neighboring gene menage a trois 1 Neighboring gene cytochrome c oxidase subunit 7A2, mitochondrial pseudogene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    anatomical structure development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    animal organ development IEA
    Inferred from Electronic Annotation
    more info
     
    aorta morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    branching involved in ureteric bud morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    cochlea morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic cranial skeleton morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    embryonic skeletal system morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    facial nerve morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fungiform papilla morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    generation of neurons IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    inner ear development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    inner ear morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mesonephric tubule formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    metanephric mesenchyme development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    middle ear morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    myoblast migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    myotome development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of branching involved in ureteric bud morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron fate specification IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    olfactory placode formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    organ induction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    otic vesicle development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    otic vesicle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    outflow tract morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    pattern specification process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    pattern specification process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    pharyngeal system development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    pharyngeal system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of branching involved in ureteric bud morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of mesenchymal cell proliferation involved in ureter development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of secondary heart field cardioblast proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of ureteric bud formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of branch elongation involved in ureteric bud branching IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of neuron differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of protein localization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of skeletal muscle cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of skeletal muscle satellite cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of synaptic growth at neuromuscular junction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    renal system development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    skeletal muscle tissue development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    skeletal muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    skeletal system morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    thymus development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    thymus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    thyroid gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    tongue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    trigeminal ganglion development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ureter smooth muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ureteric bud development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    ureteric bud development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Preferred Names
    homeobox protein SIX1
    Names
    sine oculis homeobox homolog 1
    sine oculis-related homeobox 1 homolog

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009189.3NP_033215.2  homeobox protein SIX1

      See identical proteins and their annotated locations for NP_033215.2

      Status: VALIDATED

      Source sequence(s)
      AK031122, AK131925, AV495228, BB031732, EH094589
      Consensus CDS
      CCDS25973.1
      UniProtKB/Swiss-Prot
      Q62231
      UniProtKB/TrEMBL
      Q3V2C3, Q8BSP4
      Related
      ENSMUSP00000059026, OTTMUSP00000058166, ENSMUST00000050029, OTTMUST00000104017
      Conserved Domains (2) summary
      cd00086
      Location:129180
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam16878
      Location:9118
      SIX1_SD; Transcriptional regulator, SIX1, N-terminal SD domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      73041827..73046712 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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