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    Myocd myocardin [ Mus musculus (house mouse) ]

    Gene ID: 214384, updated on 15-May-2017
    Official Symbol
    Myocdprovided by MGI
    Official Full Name
    myocardinprovided by MGI
    Primary source
    MGI:MGI:2137495
    See related
    Ensembl:ENSMUSG00000020542 Vega:OTTMUSG00000005903
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Srfcp; BSAC2A
    Orthologs
    Location:
    11; 11 B3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (65173608..65269989, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (64990063..65083491, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 44 Neighboring gene RIKEN cDNA 1700086D15 gene Neighboring gene peroxiredoxin 6 pseudogene Neighboring gene predicted gene, 30586 Neighboring gene predicted gene 12295 Neighboring gene predicted gene, 30786 Neighboring gene predicted gene, 40026

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    R-SMAD binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    RNA polymerase II transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    contributes_to core promoter proximal region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    core promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    histone acetyltransferase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    histone deacetylase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor activity, RNA polymerase II transcription factor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor activity, RNA polymerase II transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cardiac muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cardiac ventricle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell growth involved in cardiac muscle cell development ISO
    Inferred from Sequence Orthology
    more info
     
    cellular component maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    digestive tract development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ductus arteriosus closure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hepatic stellate cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    lung alveolus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of beta-amyloid clearance ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cardiac muscle cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cyclin-dependent protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of myotube differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of platelet-derived growth factor receptor-beta signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of skeletal muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of vascular associated smooth muscle cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of vascular smooth muscle cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of DNA binding IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cardiac muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cardiac vascular smooth muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of sequence-specific DNA binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of sequence-specific DNA binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of smooth muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter involved in heart development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cell growth by extracellular stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of histone acetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of myoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of phenotypic switching IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of smooth muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    smooth muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    smooth muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    urinary bladder development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    uterus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vascular smooth muscle cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    vasculogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ventricular cardiac muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    SRF-myogenin-E12 complex IC
    Inferred by Curator
    more info
    PubMed 
    nuclear chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    myocardin
    Names
    SRF co-factor protein (cardiac and smooth muscle)
    SRF cofactor protein
    basic SAP coiled-coil transcription activator 2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145136.4NP_660118.3  myocardin isoform A

      See identical proteins and their annotated locations for NP_660118.3

      Status: VALIDATED

      Source sequence(s)
      AL669846
      Consensus CDS
      CCDS48819.1
      UniProtKB/Swiss-Prot
      Q8VIM5
      Related
      ENSMUSP00000104335.2, ENSMUST00000108695.8
      Conserved Domains (2) summary
      smart00707
      Location:106131
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02037
      Location:380413
      SAP; SAP domain
    2. NM_146386.3NP_666498.2  myocardin isoform B

      See identical proteins and their annotated locations for NP_666498.2

      Status: VALIDATED

      Source sequence(s)
      AL669846
      Consensus CDS
      CCDS24843.1
      UniProtKB/Swiss-Prot
      Q8VIM5
      Related
      ENSMUSP00000099695.3, OTTMUSP00000006096, ENSMUST00000102635.9, OTTMUST00000013135
      Conserved Domains (2) summary
      smart00707
      Location:106131
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02037
      Location:380413
      SAP; SAP domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      65173608..65269989 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248895.1XP_011247197.1  myocardin isoform X3

      UniProtKB/Swiss-Prot
      Q8VIM5
      Related
      ENSMUSP00000098603.2, OTTMUSP00000006097, ENSMUST00000101042.8, OTTMUST00000013136
      Conserved Domains (2) summary
      smart00707
      Location:2752
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02037
      Location:301334
      SAP; SAP domain
    2. XM_011248893.2XP_011247195.1  myocardin isoform X1

      Conserved Domains (2) summary
      smart00707
      Location:119144
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02037
      Location:393426
      SAP; SAP domain
    3. XM_006532816.3XP_006532879.1  myocardin isoform X2

      Conserved Domains (1) summary
      pfam02037
      Location:339372
      SAP; SAP domain
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