Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    NOX5 NADPH oxidase 5 [ Homo sapiens (human) ]

    Gene ID: 79400, updated on 12-Mar-2017
    Official Symbol
    NOX5provided by HGNC
    Official Full Name
    NADPH oxidase 5provided by HGNC
    Primary source
    HGNC:HGNC:14874
    See related
    Ensembl:ENSG00000255346 MIM:606572; Vega:OTTHUMG00000133320
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene is predominantly expressed in the testis and lymphocyte-rich areas of spleen and lymph nodes. It encodes a calcium-dependen NADPH oxidase that generates superoxide, and functions as a calcium-dependent proton channel that may regulate redox-dependent processes in lymphocytes and spermatozoa. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
    Orthologs
    Location:
    15q23
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 15 NC_000015.10 (68930500..69057161)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (69222839..69349501)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ANP32A intronic transcript 1 Neighboring gene acidic nuclear phosphoprotein 32 family member A Neighboring gene cytokine induced apoptosis inhibitor 1 pseudogene Neighboring gene sperm equatorial segment protein 1 Neighboring gene ATP binding cassette subfamily G member 2 (Junior blood group) pseudogene Neighboring gene Ewing sarcoma associated transcript 1 Neighboring gene family with sequence similarity 47 member C pseudogene Neighboring gene glucuronic acid epimerase

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association study evaluating lipoprotein-associated phospholipase A2 mass and activity at baseline and after rosuvastatin therapy.
    NHGRI GWA Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 binding to CXCR4 induces NADPH oxidase-mediated production of superoxide radicals in neurons, which is involved in the activation of neutral sphingomyelinase PubMed
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 inhibits the cellular immune response and enhances oxidative stress mediated by NADPH oxidase PubMed
    Tat tat PDGF-BB inhibits NADPH oxidase-mediated reactive oxygen species production induced by HIV-1 Tat and morphine treatment in neuroblastoma cells PubMed

    Go to the HIV-1, Human Interaction Database

    • Cellular responses to stress, organism-specific biosystem (from REACTOME)
      Cellular responses to stress, organism-specific biosystemCells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissu...
    • Detoxification of Reactive Oxygen Species, organism-specific biosystem (from REACTOME)
      Detoxification of Reactive Oxygen Species, organism-specific biosystemReactive oxygen species such as superoxide (O2.-), peroxides (ROOR), singlet oxygen, peroxynitrite (ONOO-), and hydroxyl radical (OH.) are generated by cellular processes such as respiration (reviewe...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC149776, MGC149777

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NADP binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    flavin adenine dinucleotide binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    heme binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    hydrogen ion channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    superoxide-generating NADPH oxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    superoxide-generating NADPH oxidase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    apoptotic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cell proliferation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cytokine secretion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cytokinesis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    endothelial cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oxidation-reduction process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proton transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of fusion of sperm to egg plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    regulation of proton transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    response to reactive oxygen species TAS
    Traceable Author Statement
    more info
     
    superoxide anion generation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    NADPH oxidase 5
    Names
    NADPH oxidase, EF-hand calcium binding domain 5

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030464.1 RefSeqGene

      Range
      5001..131663
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184779.1NP_001171708.1  NADPH oxidase 5 isoform 2

      See identical proteins and their annotated locations for NP_001171708.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, alternately referred to as NOX5 alpha and v1) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC027088, AF353088, AI091544, DA868876, DQ413001
      Consensus CDS
      CCDS53954.1
      UniProtKB/Swiss-Prot
      Q96PH1
      UniProtKB/TrEMBL
      A3QRJ0
      Related
      ENSP00000432440, OTTHUMP00000229833, ENST00000530406, OTTHUMT00000384197
      Conserved Domains (4) summary
      cd06186
      Location:420737
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      cd00051
      Location:97164
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam01794
      Location:268374
      Ferric_reduct; Ferric reductase like transmembrane component
      pfam13499
      Location:98162
      EF-hand_7; EF-hand domain pair
    2. NM_001184780.1NP_001171709.1  NADPH oxidase 5 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, alternately referred to as v6) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. This variant also uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC027088, AC087639, AF325189, AI091544, BC125097, DA739867, DQ413001
      Consensus CDS
      CCDS53953.1
      UniProtKB/Swiss-Prot
      Q96PH1
      UniProtKB/TrEMBL
      A3QRJ0
      Related
      ENSP00000416828, OTTHUMP00000247566, ENST00000455873, OTTHUMT00000416640
      Conserved Domains (4) summary
      cd06186
      Location:413730
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      cd00051
      Location:90157
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam01794
      Location:261367
      Ferric_reduct; Ferric reductase like transmembrane component
      pfam13499
      Location:91155
      EF-hand_7; EF-hand domain pair
    3. NM_024505.3NP_078781.3  NADPH oxidase 5 isoform 1

      See identical proteins and their annotated locations for NP_078781.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, alternately referred to as NOX5 gamma and v3) encodes the longest isoform (1).
      Source sequence(s)
      AC027088, AF353089, AI091544, DA868876, DQ413001
      Consensus CDS
      CCDS32276.2
      UniProtKB/Swiss-Prot
      Q96PH1
      UniProtKB/TrEMBL
      A3QRJ0
      Related
      ENSP00000373518, OTTHUMP00000164445, ENST00000388866, OTTHUMT00000257124
      Conserved Domains (4) summary
      cd06186
      Location:448765
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      cd00051
      Location:97192
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam01794
      Location:296402
      Ferric_reduct; Ferric reductase like transmembrane component
      pfam13499
      Location:98190
      EF-hand_7; EF-hand domain pair

    RNA

    1. NR_033671.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4, also known as NOX5 delta) contains two alternate 5' exons and lacks an exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 3, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC027088, AC087639, AF325190, AI091544
    2. NR_033672.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5, also known as NOX5 beta) contains two alternate exons, lacks an alternate exon, and uses an alternate splice site compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 3, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC027088, AC087639, AF325189, AI091544, DA739867, DQ413001
      Related
      ENST00000448182, OTTHUMT00000413443

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p7 Primary Assembly

      Range
      68930500..69057161
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018926.2 Alternate CHM1_1.1

      Range
      69340923..69467659
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center