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    Tnfsf13b tumor necrosis factor (ligand) superfamily, member 13b [ Mus musculus (house mouse) ]

    Gene ID: 24099, updated on 4-Jun-2017
    Official Symbol
    Tnfsf13bprovided by MGI
    Official Full Name
    tumor necrosis factor (ligand) superfamily, member 13bprovided by MGI
    Primary source
    MGI:MGI:1344376
    See related
    Ensembl:ENSMUSG00000031497 Vega:OTTMUSG00000059081
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BAFF; BLyS; TALL1; THANK; zTNF4; TALL-1; Tnlg7a; TNFSF20; D8Ertd387e
    Orthologs
    Location:
    8 A1.1; 8 4.55 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (10006203..10036000)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (10006633..10036000)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene abhydrolase domain containing 13 Neighboring gene ligase IV, DNA, ATP-dependent Neighboring gene myosin XVI Neighboring gene predicted gene, 32330

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Chemically induced (ENU) (3) 
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC124060, MGC124061

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    tumor necrosis factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    B cell costimulation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    B cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    T cell costimulation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    immune response IEA
    Inferred from Electronic Annotation
    more info
     
    immunoglobulin secretion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of B cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of T cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of germinal center formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    tumor necrosis factor ligand superfamily member 13B
    Names
    b cell-activating factor
    tumor necrosis factor ligand 7a

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347309.1NP_001334238.1  tumor necrosis factor ligand superfamily member 13B isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC138397, AK079180, BC106840
      Consensus CDS
      CCDS85498.1
      UniProtKB/Swiss-Prot
      Q9WU72
      UniProtKB/TrEMBL
      Q8BVA3
    2. NM_033622.1NP_296371.1  tumor necrosis factor ligand superfamily member 13B isoform 1

      See identical proteins and their annotated locations for NP_296371.1

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AF119383
      Consensus CDS
      CCDS22094.1
      UniProtKB/Swiss-Prot
      Q9WU72
      UniProtKB/TrEMBL
      Q3KP92
      Related
      ENSMUSP00000146694.1, OTTMUSP00000075508, ENSMUST00000207792.1, OTTMUST00000144929
      Conserved Domains (2) summary
      cd00184
      Location:170306
      TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...
      cl11564
      Location:81155
      GcrA; GcrA cell cycle regulator

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      10006203..10036000
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508774.3XP_006508837.1  tumor necrosis factor ligand superfamily member 13B isoform X1

      Related
      ENSMUSP00000033892.8, OTTMUSP00000075509, ENSMUST00000033892.8, OTTMUST00000144932
      Conserved Domains (2) summary
      cd00184
      Location:164287
      TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...
      cl11564
      Location:81155
      GcrA; GcrA cell cycle regulator
    2. XM_006508775.3XP_006508838.1  tumor necrosis factor ligand superfamily member 13B isoform X2

      UniProtKB/TrEMBL
      A0A0U5J6R6
      Conserved Domains (1) summary
      cd00184
      Location:139275
      TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...

    RNA

    1. XR_378661.3 RNA Sequence

      Related
      ENSMUST00000208683.1, OTTMUST00000144928
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