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    hcf-1 human HCF1 related [ Caenorhabditis elegans ]

    Gene ID: 177560, updated on 12-Oct-2017
    Gene symbol
    hcf-1
    Gene description
    human HCF1 related
    Primary source
    WormBase:WBGene00001827
    Locus tag
    CELE_C46A5.9
    Gene type
    protein coding
    RNA name
    human HCF1 related
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Location:
    chromosome: IV
    Exon count:
    7
    Sequence:
    Chromosome: IV; NC_003282.8 (7771206..7774270, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Rentinal Degeneration 3-Like Neighboring gene Set1 WD40 repeat protein homolog Neighboring gene Set1 WD40 repeat protein homolog

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Longevity regulating pathway - worm, organism-specific biosystem (from KEGG)
      Longevity regulating pathway - worm, organism-specific biosystemThe nematode Caenorhabditis elegans has proven to be a very useful tool for studying the genetics of longevity due to its simple biology. Over 70 genes have been found to influence lifespan in this w...
    • Longevity regulating pathway - worm, conserved biosystem (from KEGG)
      Longevity regulating pathway - worm, conserved biosystemThe nematode Caenorhabditis elegans has proven to be a very useful tool for studying the genetics of longevity due to its simple biology. Over 70 genes have been found to influence lifespan in this w...

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    dauer exit IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    determination of adult lifespan IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription by transcription factor localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of vulval development IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    response to cadmium ion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Names
    human HCF1 related
    NP_501279.1
    • Confirmed by transcript evidence;
      Product from WormBase gene class hcf

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      7771206..7774270 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068878.4NP_501279.1  human HCF1 related [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501279.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EC23
      Conserved Domains (7) summary
      smart00060
      Location:641739
      FN3; Fibronectin type 3 domain
      cd00063
      Location:606635
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      sd00038
      Location:212267
      Kelch; KELCH repeat [structural motif]
      pfam01344
      Location:4381
      Kelch_1; Kelch motif
      pfam09184
      Location:488546
      PPP4R2; PPP4R2
      pfam13415
      Location:102155
      Kelch_3; Galactose oxidase, central domain
      pfam13854
      Location:334376
      Kelch_5; Kelch motif
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