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    Csf3r colony stimulating factor 3 receptor (granulocyte) [ Mus musculus (house mouse) ]

    Gene ID: 12986, updated on 5-Nov-2017
    Official Symbol
    Csf3rprovided by MGI
    Official Full Name
    colony stimulating factor 3 receptor (granulocyte)provided by MGI
    Primary source
    MGI:MGI:1339755
    See related
    Ensembl:ENSMUSG00000028859 Vega:OTTMUSG00000009297
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cd114; Csfgr; G-CSFR; G-CSF-R
    Orthologs
    Location:
    4 D2.2; 4 59.77 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (126023441..126044975)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (125701903..125721684)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 40249 Neighboring gene RIKEN cDNA 2610028E06 gene Neighboring gene predicted gene, 32908 Neighboring gene mitochondrial ribosomal protein S15 Neighboring gene ribosomal protein L28, pseudogene 3 Neighboring gene organic solute carrier partner 1

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, organism-specific biosystem (from WikiPathways)
      Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
      Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Hematopoietic cell lineage, conserved biosystem (from KEGG)
      Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
      Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
      Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
      PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
      PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC141472, MGC141473

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cytokine receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    granulocyte colony-stimulating factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    neutrophil chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of myeloid cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    granulocyte colony-stimulating factor receptor
    Names
    G-CSF receptor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252651.1NP_001239580.1  granulocyte colony-stimulating factor receptor isoform 2 precursor

      See identical proteins and their annotated locations for NP_001239580.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two exons in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AL627101
      Conserved Domains (4) summary
      smart00060
      Location:422503
      FN3; Fibronectin type 3 domain
      cd00063
      Location:246318
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam06328
      Location:24111
      Lep_receptor_Ig; Ig-like C2-type domain
      cl21522
      Location:123221
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    2. NM_007782.3NP_031808.2  granulocyte colony-stimulating factor receptor isoform 1 precursor

      See identical proteins and their annotated locations for NP_031808.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK089305, AK144318, AL627101
      Consensus CDS
      CCDS18640.1
      UniProtKB/Swiss-Prot
      P40223
      Related
      ENSMUSP00000101768.1, OTTMUSP00000009665, ENSMUST00000106162.7, OTTMUST00000021097
      Conserved Domains (4) summary
      smart00060
      Location:530611
      FN3; Fibronectin type 3 domain
      cd00063
      Location:354426
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam06328
      Location:24111
      Lep_receptor_Ig; Ig-like C2-type domain
      cl21522
      Location:123221
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RNA

    1. NR_045561.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) use an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK144318, AL627101

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      126023441..126044975
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502709.2XP_006502772.1  granulocyte colony-stimulating factor receptor isoform X1

      See identical proteins and their annotated locations for XP_006502772.1

      UniProtKB/Swiss-Prot
      P40223
      Conserved Domains (4) summary
      smart00060
      Location:530611
      FN3; Fibronectin type 3 domain
      cd00063
      Location:354426
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam06328
      Location:24111
      Lep_receptor_Ig; Ig-like C2-type domain
      cl21522
      Location:123221
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    2. XM_017319945.1XP_017175434.1  granulocyte colony-stimulating factor receptor isoform X5

    3. XM_006502714.2XP_006502777.1  granulocyte colony-stimulating factor receptor isoform X1

      See identical proteins and their annotated locations for XP_006502777.1

      UniProtKB/Swiss-Prot
      P40223
      Conserved Domains (4) summary
      smart00060
      Location:530611
      FN3; Fibronectin type 3 domain
      cd00063
      Location:354426
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam06328
      Location:24111
      Lep_receptor_Ig; Ig-like C2-type domain
      cl21522
      Location:123221
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    4. XM_006502712.3XP_006502775.1  granulocyte colony-stimulating factor receptor isoform X1

      See identical proteins and their annotated locations for XP_006502775.1

      UniProtKB/Swiss-Prot
      P40223
      Conserved Domains (4) summary
      smart00060
      Location:530611
      FN3; Fibronectin type 3 domain
      cd00063
      Location:354426
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam06328
      Location:24111
      Lep_receptor_Ig; Ig-like C2-type domain
      cl21522
      Location:123221
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    5. XM_011240422.2XP_011238724.1  granulocyte colony-stimulating factor receptor isoform X1

      See identical proteins and their annotated locations for XP_011238724.1

      UniProtKB/Swiss-Prot
      P40223
      Conserved Domains (4) summary
      smart00060
      Location:530611
      FN3; Fibronectin type 3 domain
      cd00063
      Location:354426
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam06328
      Location:24111
      Lep_receptor_Ig; Ig-like C2-type domain
      cl21522
      Location:123221
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    6. XM_006502716.3XP_006502779.1  granulocyte colony-stimulating factor receptor isoform X3

      See identical proteins and their annotated locations for XP_006502779.1

      Conserved Domains (3) summary
      smart00060
      Location:397478
      FN3; Fibronectin type 3 domain
      cd00063
      Location:221293
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl21522
      Location:688
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    7. XM_006502710.3XP_006502773.1  granulocyte colony-stimulating factor receptor isoform X1

      See identical proteins and their annotated locations for XP_006502773.1

      UniProtKB/Swiss-Prot
      P40223
      Conserved Domains (4) summary
      smart00060
      Location:530611
      FN3; Fibronectin type 3 domain
      cd00063
      Location:354426
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam06328
      Location:24111
      Lep_receptor_Ig; Ig-like C2-type domain
      cl21522
      Location:123221
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    8. XM_006502713.2XP_006502776.1  granulocyte colony-stimulating factor receptor isoform X1

      See identical proteins and their annotated locations for XP_006502776.1

      UniProtKB/Swiss-Prot
      P40223
      Related
      ENSMUSP00000030673.6, ENSMUST00000030673.6
      Conserved Domains (4) summary
      smart00060
      Location:530611
      FN3; Fibronectin type 3 domain
      cd00063
      Location:354426
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam06328
      Location:24111
      Lep_receptor_Ig; Ig-like C2-type domain
      cl21522
      Location:123221
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    9. XM_011240421.2XP_011238723.1  granulocyte colony-stimulating factor receptor isoform X1

      See identical proteins and their annotated locations for XP_011238723.1

      UniProtKB/Swiss-Prot
      P40223
      Conserved Domains (4) summary
      smart00060
      Location:530611
      FN3; Fibronectin type 3 domain
      cd00063
      Location:354426
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam06328
      Location:24111
      Lep_receptor_Ig; Ig-like C2-type domain
      cl21522
      Location:123221
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    10. XM_006502708.3XP_006502771.1  granulocyte colony-stimulating factor receptor isoform X1

      See identical proteins and their annotated locations for XP_006502771.1

      UniProtKB/Swiss-Prot
      P40223
      Conserved Domains (4) summary
      smart00060
      Location:530611
      FN3; Fibronectin type 3 domain
      cd00063
      Location:354426
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam06328
      Location:24111
      Lep_receptor_Ig; Ig-like C2-type domain
      cl21522
      Location:123221
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    11. XM_006502711.3XP_006502774.1  granulocyte colony-stimulating factor receptor isoform X1

      See identical proteins and their annotated locations for XP_006502774.1

      UniProtKB/Swiss-Prot
      P40223
      Conserved Domains (4) summary
      smart00060
      Location:530611
      FN3; Fibronectin type 3 domain
      cd00063
      Location:354426
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam06328
      Location:24111
      Lep_receptor_Ig; Ig-like C2-type domain
      cl21522
      Location:123221
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    12. XM_011240423.2XP_011238725.1  granulocyte colony-stimulating factor receptor isoform X2

      See identical proteins and their annotated locations for XP_011238725.1

      Conserved Domains (4) summary
      smart00060
      Location:422503
      FN3; Fibronectin type 3 domain
      cd00063
      Location:246318
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam06328
      Location:24111
      Lep_receptor_Ig; Ig-like C2-type domain
      cl21522
      Location:123221
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    13. XM_017319944.1XP_017175433.1  granulocyte colony-stimulating factor receptor isoform X1

      UniProtKB/Swiss-Prot
      P40223
      Conserved Domains (4) summary
      smart00060
      Location:530611
      FN3; Fibronectin type 3 domain
      cd00063
      Location:354426
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam06328
      Location:24111
      Lep_receptor_Ig; Ig-like C2-type domain
      cl21522
      Location:123221
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    14. XM_006502717.2XP_006502780.1  granulocyte colony-stimulating factor receptor isoform X3

      See identical proteins and their annotated locations for XP_006502780.1

      Conserved Domains (3) summary
      smart00060
      Location:397478
      FN3; Fibronectin type 3 domain
      cd00063
      Location:221293
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl21522
      Location:688
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    15. XM_006502718.2XP_006502781.1  granulocyte colony-stimulating factor receptor isoform X4

      Conserved Domains (2) summary
      smart00060
      Location:331412
      FN3; Fibronectin type 3 domain
      cd00063
      Location:155227
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    16. XM_006502719.3XP_006502782.1  granulocyte colony-stimulating factor receptor isoform X6

      Conserved Domains (2) summary
      smart00060
      Location:172253
      FN3; Fibronectin type 3 domain
      cd00063
      Location:75166
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
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