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    TXNRD2 thioredoxin reductase 2 [ Homo sapiens (human) ]

    Gene ID: 10587, updated on 22-Apr-2017
    Official Symbol
    TXNRD2provided by HGNC
    Official Full Name
    thioredoxin reductase 2provided by HGNC
    Primary source
    HGNC:HGNC:18155
    See related
    Ensembl:ENSG00000184470 MIM:606448; Vega:OTTHUMG00000149975
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TR; TR3; SELZ; TRXR2; TR-BETA
    Summary
    This gene encodes a member of the class I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein is a selenocysteine-containing flavoenzyme that maintains thioredoxins in a reduced state, thereby playing a key role in regulating the cellular redox environment. Mammals have three related thioredoxin reductases. This gene encodes a mitochondrial form important for scavenging of reactive oxygen species in mitochondria. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2013]
    Orthologs
    Location:
    22q11.21
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 22 NC_000022.11 (19875518..19941992, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (19863040..19929359, complement)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7a pseudogene 70 Neighboring gene G protein subunit beta 1 like Neighboring gene retrotransposon Gag like 10 Neighboring gene ribosomal protein L8 pseudogene 5 Neighboring gene catechol-O-methyltransferase Neighboring gene microRNA 4761 Neighboring gene armadillo repeat gene deleted in velocardiofacial syndrome

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome wide association study of SNP-, gene-, and pathway-based approaches to identify genes influencing susceptibility to Staphylococcus aureus infections.
    NHGRI GWA Catalog
    Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    matrix gag HIV-1 MA upregulates TXNRD2 (TR3) gene expression in HepG2 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    thioredoxin-disulfide reductase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    thioredoxin-disulfide reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    thioredoxin-disulfide reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    cell redox homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    response to oxygen radical TAS
    Traceable Author Statement
    more info
    PubMed 
    response to reactive oxygen species TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    mitochondrial matrix TAS
    Traceable Author Statement
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    thioredoxin reductase 2, mitochondrial
    Names
    selenoprotein Z
    thioredoxin reductase 3
    thioredoxin reductase TR3
    thioredoxin reductase beta
    NP_001269441.1
    NP_006431.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011835.1 RefSeqGene

      Range
      4845..71320
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_417

    mRNA and Protein(s)

    1. NM_001282512.1NP_001269441.1  thioredoxin reductase 2, mitochondrial isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks exons in the 3' coding region and uses an alternate 3' terminal exon compared to variant 1. The resulting protein (isoform 2) has a shorter, distinct C-terminus compared to isoform 1 and does not contain selenocysteine.
      Source sequence(s)
      AC000078, AF044212, AF106697
      Consensus CDS
      CCDS63402.1
      UniProtKB/Swiss-Prot
      Q9NNW7
      UniProtKB/TrEMBL
      E7EWK1
      Related
      ENSP00000334451.9, OTTHUMP00000281486, ENST00000334363.14, OTTHUMT00000488472
      Conserved Domains (2) summary
      pfam00070
      Location:220295
      Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
      cl14785
      Location:124190
      FMT_C_like; Carboxy-terminal domain of Formyltransferase and similar domains
    2. NM_006440.4NP_006431.2  thioredoxin reductase 2, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_006431.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
      Source sequence(s)
      AF044212, AF106697, R46611
      Consensus CDS
      CCDS42981.1
      UniProtKB/Swiss-Prot
      Q9NNW7
      Related
      ENSP00000383365.1, OTTHUMP00000195708, ENST00000400521.6, OTTHUMT00000314903
      Conserved Domains (4) summary
      TIGR01438
      Location:39524
      TGR; thioredoxin and glutathione reductase selenoprotein
      pfam00070
      Location:220295
      Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
      pfam02852
      Location:396505
      Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain
      cl14785
      Location:124190
      FMT_C_like; Carboxy-terminal domain of Formyltransferase and similar domains

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p7 Primary Assembly

      Range
      19875518..19941992 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018933.2 Alternate CHM1_1.1

      Range
      19862755..19929279 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_145747.1: Suppressed sequence

      Description
      NM_145747.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    2. NM_145748.1: Suppressed sequence

      Description
      NM_145748.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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