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    EST1 Est1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850934, updated on 6-Aug-2017
    Gene symbol
    EST1
    Gene description
    Est1p
    Primary source
    SGD:S000004223
    Locus tag
    YLR233C
    Gene type
    protein coding
    RNA name
    Est1p
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    See EST1 in Map Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (607425..609524, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene tRNA Neighboring gene kynureninase Neighboring gene DNA topoisomerase 3 Neighboring gene hypothetical protein

    Related articles in PubMed

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ribonucleoprotein complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    telomerase RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    telomeric DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    G-quadruplex DNA formation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA phosphodiester bond hydrolysis IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of RNA stability IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of telomere maintenance via telomerase IDA
    Inferred from Direct Assay
    more info
    PubMed 
    telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    telomere maintenance via telomerase IDA
    Inferred from Direct Assay
    more info
    PubMed 
    telomere maintenance via telomerase IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    telomerase holoenzyme complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    telomerase holoenzyme complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Names
    Est1p
    NP_013334.1
    • TLC1 RNA-associated factor involved in telomere length regulation; recruitment subunit of telomerase; has G-quadruplex promoting activity required for telomere elongation; role in activating telomere-bound Est2p-TLC1-RNA; EST1 has a paralog, EBS1, that arose from the whole genome duplication

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      607425..609524 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182120.1NP_013334.1  TPA: Est1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013334.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P17214
      Conserved Domains (2) summary
      pfam10373
      Location:224508
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:82207
      EST1; Telomerase activating protein Est1
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