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    KLK2 kallikrein related peptidase 2 [ Homo sapiens (human) ]

    Gene ID: 3817, updated on 9-Apr-2017
    Official Symbol
    KLK2provided by HGNC
    Official Full Name
    kallikrein related peptidase 2provided by HGNC
    Primary source
    HGNC:HGNC:6363
    See related
    Ensembl:ENSG00000167751 MIM:147960; Vega:OTTHUMG00000182963
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    hK2; hGK-1; KLK2A2
    Summary
    This gene encodes a member of the grandular kallikrein protein family. Kallikreins are a subgroup of serine proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array of biological functions. The protein encoded by this gene is a highly active trypsin-like serine protease that selectively cleaves at arginine residues. This protein is primarily expressed in prostatic tissue and is responsible for cleaving pro-prostate-specific antigen into its enzymatically active form. This gene is highly expressed in prostate tumor cells and may be a prognostic maker for prostate cancer risk. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Jan 2012]
    Orthologs
    Location:
    19q13.33
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 19 NC_000019.10 (50873433..50880567)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51376689..51383823)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372441 Neighboring gene kallikrein related peptidase 15 Neighboring gene kallikrein related peptidase 3 Neighboring gene kallikrein pseudogene 1 Neighboring gene kallikrein related peptidase 4

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease.
    NHGRI GWA Catalog
    Genome-wide association study identifies genetic determinants of urine PCA3 levels in men.
    NHGRI GWA Catalog
    Genome-wide association study identifies loci at ATF7IP and KLK2 associated with percentage of circulating free PSA.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Clone Names

    • FLJ17010, FLJ17011, MGC12201

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    serine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    serine-type endopeptidase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    extracellular matrix disassembly TAS
    Traceable Author Statement
    more info
     
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    kallikrein-2
    Names
    glandular kallikrein 2
    glandular kallikrein-1
    kallikrein 2, prostatic
    tissue kallikrein-2
    NP_001002231.1
    NP_001243009.1
    NP_005542.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_031984.1 RefSeqGene

      Range
      5001..12135
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001002231.2NP_001002231.1  kallikrein-2 isoform 2 preproprotein

      See identical proteins and their annotated locations for NP_001002231.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC037199, AF188745, AF188747, AK300527
      Consensus CDS
      CCDS42597.1
      UniProtKB/Swiss-Prot
      P20151
      UniProtKB/TrEMBL
      A0A024R4N3, B4DU77
      Related
      ENSP00000350748.3, OTTHUMP00000270554, ENST00000358049.8, OTTHUMT00000464444
      Conserved Domains (2) summary
      smart00020
      Location:24209
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:25209
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    2. NM_001256080.1NP_001243009.1  kallikrein-2 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC037199, AF188745, AK300527, AK300549
      Consensus CDS
      CCDS58675.1
      UniProtKB/Swiss-Prot
      P20151
      UniProtKB/TrEMBL
      B4DU77
      Related
      ENSP00000375686.2, ENST00000391810.6
      Conserved Domains (2) summary
      smart00020
      Location:13151
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:16154
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    3. NM_005551.4NP_005542.1  kallikrein-2 isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_005542.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC037199, AF188746, AK300527
      Consensus CDS
      CCDS12808.1
      UniProtKB/Swiss-Prot
      P20151
      UniProtKB/TrEMBL
      A0A024R4J4, B4DU77
      Related
      ENSP00000313581.2, OTTHUMP00000270550, ENST00000325321.7, OTTHUMT00000464438
      Conserved Domains (2) summary
      smart00020
      Location:24253
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:25256
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RNA

    1. NR_045762.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC037199, AF188745
      Related
      ENST00000597439.1, OTTHUMT00000464445
    2. NR_045763.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate splice site, compared to variant 1. This variant (5) is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC037199, AF188745, AK300527

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p7 Primary Assembly

      Range
      50873433..50880567
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018930.2 Alternate CHM1_1.1

      Range
      51378497..51385627
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001002232.2: Suppressed sequence

      Description
      NM_001002232.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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