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    IL1RL1 interleukin 1 receptor like 1 [ Homo sapiens (human) ]

    Gene ID: 9173, updated on 22-May-2018
    Official Symbol
    IL1RL1provided by HGNC
    Official Full Name
    interleukin 1 receptor like 1provided by HGNC
    Primary source
    HGNC:HGNC:5998
    See related
    Ensembl:ENSG00000115602 MIM:601203; Vega:OTTHUMG00000130782
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    T1; ST2; DER4; ST2L; ST2V; FIT-1; IL33R
    Summary
    The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
    Annotation information
    Note: This gene, IL1RL1 (GeneID: 9173) which has the alias ST2, is found on chromosome 2. IL1RL1 encodes a member of the interleukin 1 receptor family. IL1RL1 has been confused in the published literature with ST2 (GeneID: 6761) on chromosome 11 which is a region that represents a putative locus associated with various forms of cancer. [23 Jun 2016]
    Expression
    Biased expression in placenta (RPKM 51.1), kidney (RPKM 5.3) and 3 other tissues See more
    Orthologs
    See IL1RL1 in Genome Data Viewer
    Location:
    2q12.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (102311502..102352367)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (102927962..102968497)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene interleukin 1 receptor like 2 Neighboring gene family with sequence similarity 183 member D, pseudogene Neighboring gene interleukin 18 receptor 1 Neighboring gene short chain dehydrogenase/reductase family 42E, member 1 pseudogene 5

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
    NHGRI GWA Catalog
    Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling.
    NHGRI GWA Catalog
    Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy.
    NHGRI GWA Catalog
    Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.
    NHGRI GWA Catalog
    Genome-wide association of body fat distribution in African ancestry populations suggests new loci.
    NHGRI GWA Catalog
    Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA.
    NHGRI GWA Catalog
    Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.
    NHGRI GWA Catalog
    Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
    NHGRI GWA Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    NHGRI GWA Catalog
    Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization.
    NHGRI GWA Catalog
    Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
    NHGRI GWA Catalog
    Multiple common variants for celiac disease influencing immune gene expression.
    NHGRI GWA Catalog
    Newly identified genetic risk variants for celiac disease related to the immune response.
    NHGRI GWA Catalog
    Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction.
    NHGRI GWA Catalog

    Replication interactions

    Interaction Pubs
    In vitro infection with HIV-1 subtype B upregulates ST2L expression in primary human astrocytes and SKNMC cells PubMed

    Go to the HIV-1, Human Interaction Database

    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC32623, DKFZp564N1164

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cytokine receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    interleukin-1 receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    interleukin-33 binding IEA
    Inferred from Electronic Annotation
    more info
     
    interleukin-33 receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    immune response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    interleukin-33-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    negative regulation of I-kappaB kinase/NF-kappaB signaling IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of T-helper 1 type immune response IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of interferon-gamma production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of chemokine secretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-5 production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of macrophage activation IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    interleukin-1 receptor-like 1
    Names
    growth stimulation-expressed
    homolog of mouse growth stimulation-expressed
    interleukin 1 receptor-related protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282408.1NP_001269337.1  interleukin-1 receptor-like 1 isoform 3

      See identical proteins and their annotated locations for NP_001269337.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has multiple differences, compared to variant 1. These differences result in distinct 5' and 3' UTRs, cause translation initiation at a downstream start codon and translation termination at a different stop codon, compared to variant 1. It encodes isoform 3 which has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AB012701, AK303389, AL117622, BC030975, BQ012352
      Consensus CDS
      CCDS74548.1
      UniProtKB/Swiss-Prot
      Q01638
      Related
      ENSP00000384822.2, ENST00000404917.6
      Conserved Domains (2) summary
      cd05757
      Location:187
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      smart00410
      Location:380
      IG_like; Immunoglobulin like
    2. NM_003856.3NP_003847.2  interleukin-1 receptor-like 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_003847.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate 5' UTR exon and lacks several 3' terminal exons, and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AL117622, BC030975, BQ012352, DA884586
      Consensus CDS
      CCDS2058.1
      UniProtKB/Swiss-Prot
      Q01638
      Related
      ENSP00000310371.2, OTTHUMP00000161343, ENST00000311734.6, OTTHUMT00000253297
      Conserved Domains (2) summary
      cd05756
      Location:16104
      Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      cd05757
      Location:118204
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    3. NM_016232.4NP_057316.3  interleukin-1 receptor-like 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_057316.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AB012701, AC007248, AK291578, DB063031
      Consensus CDS
      CCDS2057.1
      UniProtKB/Swiss-Prot
      Q01638
      Related
      ENSP00000233954.1, OTTHUMP00000161342, ENST00000233954.5, OTTHUMT00000253296
      Conserved Domains (4) summary
      cd05757
      Location:118204
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      smart00410
      Location:21104
      IG_like; Immunoglobulin like
      pfam01582
      Location:380535
      TIR; TIR domain
      cl11960
      Location:16104
      Ig; Immunoglobulin domain

    RNA

    1. NR_104167.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has an alternate 5' exon, an additional internal exon which includes a premature stop codon, and an alternate 3' segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AB029084, AL117622, AL553735, BC030975, BQ012352, DA884586

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

      Range
      102311502..102352367
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011512151.1XP_011510453.1  interleukin-1 receptor-like 1 isoform X1

      See identical proteins and their annotated locations for XP_011510453.1

      UniProtKB/Swiss-Prot
      Q01638
      Conserved Domains (2) summary
      cd05756
      Location:16104
      Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      cd05757
      Location:118204
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    2. XM_006712839.3XP_006712902.1  interleukin-1 receptor-like 1 isoform X2

      See identical proteins and their annotated locations for XP_006712902.1

      UniProtKB/Swiss-Prot
      Q01638
      Conserved Domains (4) summary
      cd05757
      Location:118204
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      smart00410
      Location:21104
      IG_like; Immunoglobulin like
      pfam01582
      Location:380535
      TIR; TIR domain
      cl11960
      Location:16104
      Ig; Immunoglobulin domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_173459.1: Suppressed sequence

      Description
      NM_173459.1: This RefSeq was permantly suppressed because it represented an alternate exon that was weakly supported and resulted in premature truncation of the protein and a transcript which is a nonsense-mediated decay (NMD) ca
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