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    SULT1A3 sulfotransferase family 1A member 3 [ Homo sapiens (human) ]

    Gene ID: 6818, updated on 9-Apr-2017
    Official Symbol
    SULT1A3provided by HGNC
    Official Full Name
    sulfotransferase family 1A member 3provided by HGNC
    Primary source
    HGNC:HGNC:11455
    See related
    Ensembl:ENSG00000261052 MIM:600641; Vega:OTTHUMG00000048083
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    STM; HAST; HAST3; M-PST; ST1A3; ST1A5; TL-PST; ST1A3/ST1A4
    Summary
    Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16; this gene and SULT1A4 arose from a segmental duplication. This gene is the most centromeric of the four sulfotransferase genes. Read-through transcription exists between this gene and the upstream SLX1A (SLX1 structure-specific endonuclease subunit homolog A) gene that encodes a protein containing GIY-YIG domains. [provided by RefSeq, Nov 2010]
    Orthologs
    Location:
    16p11.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 16 NC_000016.10 (30199228..30204329)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (30210549..30215650)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984834 Neighboring gene SLX1A-SULT1A3 readthrough (NMD candidate) Neighboring gene coronin 1A Neighboring gene bolA family member 2B Neighboring gene SLX1 homolog A, structure-specific endonuclease subunit Neighboring gene uncharacterized LOC101929894 Neighboring gene SAGA complex associated factor 29 pseudogene Neighboring gene nuclear pore complex interacting protein family, member B13 Neighboring gene SMG1P5, nonsense mediated mRNA decay associated PI3K related kinase pseudogene 5

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Biological oxidations, organism-specific biosystem (from REACTOME)
      Biological oxidations, organism-specific biosystemAll organisms are constantly exposed to foreign chemicals every day. These can be man-made (drugs, industrial chemicals) or natural (alkaloids, toxins from plants and animals). Uptake is usually via ...
    • Chemical carcinogenesis, organism-specific biosystem (from KEGG)
      Chemical carcinogenesis, organism-specific biosystemIt has been estimated that exposure to environmental chemical carcinogens may contribute significantly to the causation of a sizable fraction, perhaps a majority, of human cancers. Human carcinogens ...
    • Chemical carcinogenesis, conserved biosystem (from KEGG)
      Chemical carcinogenesis, conserved biosystemIt has been estimated that exposure to environmental chemical carcinogens may contribute significantly to the causation of a sizable fraction, perhaps a majority, of human cancers. Human carcinogens ...
    • Cytosolic sulfonation of small molecules, organism-specific biosystem (from REACTOME)
      Cytosolic sulfonation of small molecules, organism-specific biosystemTwo groups of sulfotransferease (SULT) enzymes catalyze the transfer of a sulfate group from 3-phosphoadenosine 5-phosphosulfate (PAPS) to a hydroxyl group on an acceptor molecule, yielding a sulfona...
    • IRE1alpha activates chaperones, organism-specific biosystem (from REACTOME)
      IRE1alpha activates chaperones, organism-specific biosystemIRE1-alpha is a single-pass transmembrane protein that resides in the endoplasmic reticulum (ER) membrane. The C-terminus of IRE1-alpha is located in the cytosol; the N-terminus is located in the ER ...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Phase II conjugation, organism-specific biosystem (from REACTOME)
      Phase II conjugation, organism-specific biosystemPhase II of biotransformation is concerned with conjugation, that is using groups from cofactors to react with functional groups present or introduced from phase I on the compound. The enzymes involv...
    • Unfolded Protein Response (UPR), organism-specific biosystem (from REACTOME)
      Unfolded Protein Response (UPR), organism-specific biosystemThe Unfolded Protein Response (UPR) is a regulatory system that protects the Endoplasmic Reticulum (ER) from overload. The UPR is provoked by the accumulation of improperly folded protein in the ER d...
    • XBP1(S) activates chaperone genes, organism-specific biosystem (from REACTOME)
      XBP1(S) activates chaperone genes, organism-specific biosystemXbp-1 (S) binds the sequence CCACG in ER Stress Responsive Elements (ERSE, consensus sequence CCAAT (N)9 CCACG) located upstream from many genes. The ubiquitous transcription factor NF-Y, a heterotri...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Readthrough SLX1A-SULT1A3

    Readthrough gene: SLX1A-SULT1A3, Included gene: SLX1A

    Homology

    Clone Names

    • MGC117469

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    amine sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    aryl sulfotransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    aryl sulfotransferase activity TAS
    Traceable Author Statement
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sulfate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    3'-phosphoadenosine 5'-phosphosulfate metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    3'-phosphoadenosine 5'-phosphosulfate metabolic process TAS
    Traceable Author Statement
    more info
     
    ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    IRE1-mediated unfolded protein response TAS
    Traceable Author Statement
    more info
     
    NMDA selective glutamate receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcineurin-mediated signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to dopamine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dopamine catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dopamine receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ethanol catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    flavonoid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of neuron death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    steroid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    sulfation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    xenobiotic metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    sulfotransferase 1A3
    Names
    aryl sulfotransferase 1A3/1A4
    catecholamine-sulfating phenol sulfotransferase
    dopamine-specific sulfotransferase
    monoamine-sulfating phenosulfotransferase
    phenol sulfotransferase 1A5
    placental estrogen sulfotransferase
    sulfokinase
    sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
    thermolabile (monoamine, M form) phenol sulfotransferase
    NP_808220.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177552.3NP_808220.1  sulfotransferase 1A3

      See identical proteins and their annotated locations for NP_808220.1

      Status: REVIEWED

      Source sequence(s)
      AI672638, BC078144, BC144355, DA978913
      Consensus CDS
      CCDS10674.1
      UniProtKB/Swiss-Prot
      P0DMM9, P0DMN0
      UniProtKB/TrEMBL
      Q1ET61
      Related
      ENSP00000343645.5, OTTHUMP00000255264, ENST00000338971.9, OTTHUMT00000434094
      Conserved Domains (1) summary
      pfam00685
      Location:38287
      Sulfotransfer_1; Sulfotransferase domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p7 Primary Assembly

      Range
      30199228..30204329
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018927.2 Alternate CHM1_1.1

      Range
      31425177..31430277
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001017387.1: Suppressed sequence

      Description
      NM_001017387.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.
    2. NM_003166.3: Suppressed sequence

      Description
      NM_003166.3: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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