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    Pgr progesterone receptor [ Mus musculus (house mouse) ]

    Gene ID: 18667, updated on 23-May-2018
    Official Symbol
    Pgrprovided by MGI
    Official Full Name
    progesterone receptorprovided by MGI
    Primary source
    MGI:MGI:97567
    See related
    Ensembl:ENSMUSG00000031870 Vega:OTTMUSG00000022998
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PR; PR-A; PR-B; NR3C3; BB114106; 9930019P03Rik
    Summary
    This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. [provided by RefSeq, Sep 2015]
    Expression
    Biased expression in subcutaneous fat pad adult (RPKM 5.5), ovary adult (RPKM 4.9) and 6 other tissues See more
    Orthologs
    See Pgr in Genome Data Viewer
    Location:
    9; 9 A1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (8893175..8968611)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (8899833..8968611)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene microRNA 1899 Neighboring gene transient receptor potential cation channel, subfamily C, member 6 Neighboring gene predicted gene, 32014 Neighboring gene Rho GTPase activating protein 42 Neighboring gene predicted gene, 16833 Neighboring gene predicted gene, 46102

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATPase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II proximal promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    hormone binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    steroid binding ISO
    Inferred from Sequence Orthology
    more info
     
    steroid hormone receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    steroid hormone receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    epithelial cell maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    female mating behavior ISO
    Inferred from Sequence Orthology
    more info
     
    lung alveolus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mammary gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of granulosa cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    ovulation from ovarian follicle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    paracrine signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    progesterone receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to cocaine ISO
    Inferred from Sequence Orthology
    more info
     
    steroid hormone mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    tertiary branching involved in mammary gland duct morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    axon terminus ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IC
    Inferred by Curator
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    progesterone receptor
    Names
    nuclear receptor subfamily 3 group C member 3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008829.2NP_032855.2  progesterone receptor

      See identical proteins and their annotated locations for NP_032855.2

      Status: REVIEWED

      Source sequence(s)
      AC113506, AC160964, AK054117, BB149371
      Consensus CDS
      CCDS22816.1
      UniProtKB/Swiss-Prot
      Q00175
      UniProtKB/TrEMBL
      Q8BW69
      Related
      ENSMUSP00000140124.1, ENSMUST00000189181.6
      Conserved Domains (3) summary
      cd07074
      Location:679926
      NR_LBD_PR; Ligand binding domain of the progesterone receptor, a member of the nuclear hormone receptor
      cd07172
      Location:556633
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02161
      Location:1557
      Prog_receptor; Progesterone receptor

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      8893175..8968611
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509848.3XP_006509911.1  progesterone receptor isoform X1

      Conserved Domains (2) summary
      pfam02161
      Location:1557
      Prog_receptor; Progesterone receptor
      cl02596
      Location:556589
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
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