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    Glp1r glucagon-like peptide 1 receptor [ Mus musculus (house mouse) ]

    Gene ID: 14652, updated on 5-Dec-2017
    Official Symbol
    Glp1rprovided by MGI
    Official Full Name
    glucagon-like peptide 1 receptorprovided by MGI
    Primary source
    MGI:MGI:99571
    See related
    Ensembl:ENSMUSG00000024027
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GLP-1R; GLP1Rc
    Expression
    Biased expression in lung adult (RPKM 40.4), duodenum adult (RPKM 18.2) and 3 other tissues See more
    Orthologs
    Location:
    17 A3.3; 17 15.8 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (30901867..30936510)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (31038812..31073455)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700097N02 gene Neighboring gene dynein, axonemal, heavy chain 8 Neighboring gene predicted gene, 41561 Neighboring gene predicted gene, 41562 Neighboring gene uromodulin-like 1

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    G-protein coupled peptide receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    G-protein coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    glucagon receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    glucagon-like peptide 1 receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    peptide hormone binding ISO
    Inferred from Sequence Orthology
    more info
     
    peptide receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    signal transducer activity IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    adenylate cyclase-activating G-protein coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    associative learning ISO
    Inferred from Sequence Orthology
    more info
     
    cAMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    feeding behavior ISO
    Inferred from Sequence Orthology
    more info
     
    hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    learning or memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    learning or memory ISO
    Inferred from Sequence Orthology
    more info
     
    memory ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    neuropeptide signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of blood pressure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of heart contraction ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    response to glucose ISO
    Inferred from Sequence Orthology
    more info
     
    response to stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    glucagon-like peptide 1 receptor
    Names
    GLP-1 receptor
    GLP-1-R

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021332.2NP_067307.2  glucagon-like peptide 1 receptor precursor

      See identical proteins and their annotated locations for NP_067307.2

      Status: PROVISIONAL

      Source sequence(s)
      DQ093397
      Consensus CDS
      CCDS37542.1
      UniProtKB/Swiss-Prot
      O35659
      Related
      ENSMUSP00000110221.1, ENSMUST00000114574.1
      Conserved Domains (2) summary
      pfam00002
      Location:141398
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02793
      Location:59128
      HRM; Hormone receptor domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      30901867..30936510
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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