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    Apobec3 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3 [ Mus musculus (house mouse) ]

    Gene ID: 80287, updated on 8-May-2017
    Official Symbol
    Apobec3provided by MGI
    Official Full Name
    apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3provided by MGI
    Primary source
    MGI:MGI:1933111
    See related
    Ensembl:ENSMUSG00000009585 Vega:OTTMUSG00000042090
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Arp3; Rfv3; Cem15; Apobec; Gm20117; BC003314
    Orthologs
    Location:
    15 E1; 15 37.85 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (79892058..79918218)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (79722838..79738859)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 30977 Neighboring gene neuronal pentraxin receptor Neighboring gene neuronal pentraxin chromo domain Neighboring gene chromobox 6 Neighboring gene RIKEN cDNA D730005E14 gene Neighboring gene chromobox 7 Neighboring gene microRNA 7213 Neighboring gene platelet derived growth factor, B polypeptide Neighboring gene predicted gene, 41361

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC7002

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    deoxycytidine deaminase activity ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    defense response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    hematopoietic progenitor cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transposition IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transposition ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of viral genome replication IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of viral life cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    DNA dC->dU-editing enzyme APOBEC-3
    Names
    apolipoprotein B editing complex 3
    apolipoprotein B mRNA-editing complex 3
    recovery from Friend virus 3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001160415.1NP_001153887.1  DNA dC->dU-editing enzyme APOBEC-3 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC113595
      Consensus CDS
      CCDS49669.1
      Related
      ENSMUSP00000105249.3, ENSMUST00000109620.9
      Conserved Domains (3) summary
      cd01283
      Location:35141
      cytidine_deaminase; Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on ...
      pfam05240
      Location:137182
      APOBEC_C; APOBEC-like C-terminal domain
      pfam08210
      Location:26195
      APOBEC_N; APOBEC-like N-terminal domain
    2. NM_001347041.1NP_001333970.1  DNA dC->dU-editing enzyme APOBEC-3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC113595
      Consensus CDS
      CCDS84179.1
      UniProtKB/TrEMBL
      Q3TI69
    3. NM_030255.3NP_084531.2  DNA dC->dU-editing enzyme APOBEC-3 isoform 2

      See identical proteins and their annotated locations for NP_084531.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1. The encoded isoform (2)is shorter than isoform 1.
      Source sequence(s)
      AA288216, AK049256, AK153719, BY228556
      Consensus CDS
      CCDS27654.1
      UniProtKB/TrEMBL
      Q3U5C5
      Related
      ENSMUSP00000132391.1, ENSMUST00000165537.7
      Conserved Domains (3) summary
      cd01283
      Location:35141
      cytidine_deaminase; Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on ...
      pfam05240
      Location:137182
      APOBEC_C; APOBEC-like C-terminal domain
      pfam08210
      Location:26195
      APOBEC_N; APOBEC-like N-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

      Range
      79892058..79918218
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316808.1XP_017172297.1  DNA dC->dU-editing enzyme APOBEC-3 isoform X3

      UniProtKB/TrEMBL
      Q3TI69
      Conserved Domains (4) summary
      cd01283
      Location:122220
      cytidine_deaminase; Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on ...
      pfam05240
      Location:3883
      APOBEC_C; APOBEC-like C-terminal domain
      pfam08210
      Location:109262
      APOBEC_N; APOBEC-like N-terminal domain
      cl00269
      Location:242
      cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...
    2. XM_017316806.1XP_017172295.1  DNA dC->dU-editing enzyme APOBEC-3 isoform X1

      Related
      ENSMUSP00000135079.1, OTTMUSP00000061567, ENSMUST00000177098.7, OTTMUST00000110385
    3. XM_006521551.2XP_006521614.1  DNA dC->dU-editing enzyme APOBEC-3 isoform X3

      Related
      ENSMUSP00000023054.7, OTTMUSP00000061566, ENSMUST00000023054.13, OTTMUST00000110382
      Conserved Domains (4) summary
      cd01283
      Location:122220
      cytidine_deaminase; Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on ...
      pfam05240
      Location:3883
      APOBEC_C; APOBEC-like C-terminal domain
      pfam08210
      Location:109262
      APOBEC_N; APOBEC-like N-terminal domain
      cl00269
      Location:242
      cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...
    4. XM_017316807.1XP_017172296.1  DNA dC->dU-editing enzyme APOBEC-3 isoform X2

    5. XM_006521553.3XP_006521616.1  DNA dC->dU-editing enzyme APOBEC-3 isoform X4

      Conserved Domains (3) summary
      cd01283
      Location:74172
      cytidine_deaminase; Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on ...
      pfam05240
      Location:168212
      APOBEC_C; APOBEC-like C-terminal domain
      pfam08210
      Location:61214
      APOBEC_N; APOBEC-like N-terminal domain

    RNA

    1. XR_001781583.1 RNA Sequence

    Reference GRCm38.p4 129S7/SvEvBrd-Hprt-b-m2

    Genomic

    1. NT_187001.1 Reference GRCm38.p4 129S7/SvEvBrd-Hprt-b-m2

      Range
      2638..14965
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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