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    Ghrh growth hormone releasing hormone [ Mus musculus (house mouse) ]

    Gene ID: 14601, updated on 4-Feb-2018
    Official Symbol
    Ghrhprovided by MGI
    Official Full Name
    growth hormone releasing hormoneprovided by MGI
    Primary source
    MGI:MGI:95709
    See related
    Ensembl:ENSMUSG00000027643 Vega:OTTMUSG00000016171
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GRF; Ghrf
    Summary
    This gene encodes a hormone that has stimulatory effects on pituitary growth hormone synthesis and release, and somatotrope expansion. The encoded preproprotein undergoes proteolytic processing to generate the mature peptide that is secreted by hypothalamus. Mice lacking the encoded protein are deficient in the growth hormone, live longer and exhibit growth retardation, enhanced insulin sensitivity and increased xenobiotic metabolism. [provided by RefSeq, Jul 2016]
    Expression
    Restricted expression toward placenta adult (RPKM 10.5) See more
    Orthologs
    Location:
    2 H1; 2 78.25 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (157329496..157348728, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (157155232..157172391, complement)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene small nuclear ribonucleoprotein Sm D1-like Neighboring gene RB transcriptional corepressor like 1 Neighboring gene maestro heat-like repeat family member 8 Neighboring gene ribophorin II Neighboring gene predicted gene, 39974 Neighboring gene mannosidase, beta A, lysosomal-like

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    growth hormone-releasing hormone activity ISO
    Inferred from Sequence Orthology
    more info
     
    growth hormone-releasing hormone receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    growth hormone-releasing hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    hormone activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    adenohypophysis development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    adenylate cyclase-activating G-protein coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adenylate cyclase-activating G-protein coupled receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    adenylate cyclase-activating G-protein coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    adenylate cyclase-activating G-protein coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    adenylate cyclase-modulating G-protein coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    circadian sleep/wake cycle, non-REM sleep ISO
    Inferred from Sequence Orthology
    more info
     
    growth hormone secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    growth hormone secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    growth hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cardiac muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cAMP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of circadian sleep/wake cycle, non-REM sleep ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of growth hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of hormone secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of multicellular organism growth IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    response to food IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    axon terminus ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    terminal bouton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    somatoliberin
    Names
    growth hormone-releasing factor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001329683.1NP_001316612.1  somatoliberin preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK018816, BX510908, BY705613
      Consensus CDS
      CCDS16976.1
      UniProtKB/Swiss-Prot
      P16043
      UniProtKB/TrEMBL
      Q544X5
      Conserved Domains (1) summary
      pfam00123
      Location:3157
      Hormone_2; Peptide hormone
    2. NM_010285.3NP_034415.1  somatoliberin preproprotein

      See identical proteins and their annotated locations for NP_034415.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK018816, BY705613
      Consensus CDS
      CCDS16976.1
      UniProtKB/Swiss-Prot
      P16043
      UniProtKB/TrEMBL
      Q544X5
      Related
      ENSMUSP00000029172.1, OTTMUSP00000017306, ENSMUST00000029172.1, OTTMUST00000038699
      Conserved Domains (1) summary
      pfam00123
      Location:3157
      Hormone_2; Peptide hormone

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      157329496..157348728 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498773.3XP_006498836.1  somatoliberin isoform X2

      Conserved Domains (1) summary
      pfam00123
      Location:3157
      Hormone_2; Peptide hormone
    2. XM_006498772.3XP_006498835.1  somatoliberin isoform X1

      Related
      ENSMUSP00000105162.1, OTTMUSP00000017307, ENSMUST00000109536.7, OTTMUST00000038700
      Conserved Domains (1) summary
      pfam00123
      Location:3157
      Hormone_2; Peptide hormone
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