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    Nr1h2 nuclear receptor subfamily 1, group H, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 22260, updated on 22-Apr-2017
    Official Symbol
    Nr1h2provided by MGI
    Official Full Name
    nuclear receptor subfamily 1, group H, member 2provided by MGI
    Primary source
    MGI:MGI:1352463
    See related
    Ensembl:ENSMUSG00000060601 Vega:OTTMUSG00000023074
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    UR; LXR; Unr; LXRB; NER1; OR-1; Unr2; RIP15; LXRBSV; LXRbeta; AI194859
    Orthologs
    Location:
    7; 7 B3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (44549616..44553968, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (51805002..51809293, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene Spi-B transcription factor (Spi-1/PU.1 related) Neighboring gene polymerase (DNA directed), delta 1, catalytic subunit Neighboring gene microRNA 7053 Neighboring gene napsin A aspartic peptidase Neighboring gene predicted gene 15396 Neighboring gene predicted gene, 45981

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II core promoter proximal region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    apolipoprotein A-I receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    retinoid X receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    retinoid X receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    steroid hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor activity, sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor activity, sequence-specific DNA binding IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cellular lipid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cholesterol homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cholesterol storage ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of lipid transport ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of pinocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cellular protein metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cholesterol efflux IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cholesterol efflux IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cholesterol efflux ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of high-density lipoprotein particle assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of lipoprotein lipase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of pancreatic juice secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of secretion of lysosomal enzymes IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of triglyceride biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cholesterol homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    retinoic acid receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    steroid hormone mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    oxysterols receptor LXR-beta
    Names
    LXR beta
    liver X receptor beta
    retinoid X receptor-interacting protein No.15
    ubiquitously-expressed nuclear receptor 2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285517.1NP_001272446.1  oxysterols receptor LXR-beta isoform a

      See identical proteins and their annotated locations for NP_001272446.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      BC066025, BY197597
      Consensus CDS
      CCDS21211.1
      UniProtKB/Swiss-Prot
      Q60644
      Related
      ENSMUSP00000073188.5, OTTMUSP00000026678, ENSMUST00000073488.11, OTTMUST00000055655
      Conserved Domains (2) summary
      cd06954
      Location:209444
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
      cl02596
      Location:58154
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
    2. NM_001285518.1NP_001272447.1  oxysterols receptor LXR-beta isoform b

      See identical proteins and their annotated locations for NP_001272447.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3 and 4 both encode the same isoform (b).
      Source sequence(s)
      AK077620, AK134489, BC066025, BQ573162, BY197597
      Consensus CDS
      CCDS71947.1
      UniProtKB/Swiss-Prot
      Q60644
      UniProtKB/TrEMBL
      Q8BP65
      Related
      ENSMUSP00000103543.1, OTTMUSP00000026680, ENSMUST00000107910.7, OTTMUST00000055657
      Conserved Domains (2) summary
      cd06954
      Location:206441
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
      cl02596
      Location:55151
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
    3. NM_001285519.1NP_001272448.1  oxysterols receptor LXR-beta isoform b

      See identical proteins and their annotated locations for NP_001272448.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3 and 4 both encode the same isoform (b).
      Source sequence(s)
      AK077620, BC066025, BY197597
      Consensus CDS
      CCDS71947.1
      UniProtKB/Swiss-Prot
      Q60644
      UniProtKB/TrEMBL
      Q8BP65
      Related
      ENSMUSP00000103544.1, OTTMUSP00000026679, ENSMUST00000107911.7, OTTMUST00000055656
      Conserved Domains (2) summary
      cd06954
      Location:206441
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
      cl02596
      Location:55151
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
    4. NM_009473.3NP_033499.1  oxysterols receptor LXR-beta isoform a

      See identical proteins and their annotated locations for NP_033499.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC157653, AK077620, BC066025, BQ573162, BY197597
      Consensus CDS
      CCDS21211.1
      UniProtKB/Swiss-Prot
      Q60644
      UniProtKB/TrEMBL
      Q8BP65
      Related
      ENSMUSP00000126788.1, ENSMUST00000167197.7
      Conserved Domains (2) summary
      cd06954
      Location:209444
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
      cl02596
      Location:58154
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      44549616..44553968 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540804.3XP_006540867.1  oxysterols receptor LXR-beta isoform X1

      See identical proteins and their annotated locations for XP_006540867.1

      UniProtKB/Swiss-Prot
      Q60644
      Related
      ENSMUSP00000103545.1, OTTMUSP00000026720, ENSMUST00000107912.7, OTTMUST00000055715
      Conserved Domains (2) summary
      cd06954
      Location:209444
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
      cl02596
      Location:58154
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
    2. XM_017322126.1XP_017177615.1  oxysterols receptor LXR-beta isoform X2

      Related
      ENSMUSP00000146466.1, OTTMUSP00000075373, ENSMUST00000208322.1, OTTMUST00000144663
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