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    Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit [ Mus musculus (house mouse) ]

    Gene ID: 12288, updated on 7-Jan-2018
    Official Symbol
    Cacna1cprovided by MGI
    Official Full Name
    calcium channel, voltage-dependent, L type, alpha 1C subunitprovided by MGI
    Primary source
    MGI:MGI:103013
    See related
    Ensembl:ENSMUSG00000051331 Vega:OTTMUSG00000049004
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MBC; Cav1.2; Cchl1a1; MELC-CC; D930026N18Rik
    Expression
    Broad expression in heart adult (RPKM 11.2), adrenal adult (RPKM 6.3) and 16 other tissues See more
    Orthologs
    Location:
    6 F1; 6 55.86 cM
    Exon count:
    53
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (118587240..119197496, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (118542314..119146427, complement)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene zinc finger protein 248 pseudogene Neighboring gene ankyrin repeat domain 26 Neighboring gene predicted gene, 38887 Neighboring gene nuclear receptor subfamily 5, group A, member 2 pseudogene Neighboring gene RIKEN cDNA 4931430N09 gene Neighboring gene ribosomal protein S3 pseudogene Neighboring gene uncharacterized LOC108169205 Neighboring gene decapping mRNA 1B Neighboring gene calcium channel, voltage-dependent, alpha 2/delta subunit 4 Neighboring gene leucine-rich repeats and transmembrane domains 2 Neighboring gene adiponectin receptor 2

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Adrenergic signaling in cardiomyocytes, organism-specific biosystem (from KEGG)
      Adrenergic signaling in cardiomyocytes, organism-specific biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
    • Adrenergic signaling in cardiomyocytes, conserved biosystem (from KEGG)
      Adrenergic signaling in cardiomyocytes, conserved biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
    • Aldosterone synthesis and secretion, organism-specific biosystem (from KEGG)
      Aldosterone synthesis and secretion, organism-specific biosystemAldosterone is a steroid hormone synthesized in and secreted from the outer layer of the adrenal cortex, the zona glomerulosa. Aldosterone plays an important role in the regulation of systemic blood ...
    • Aldosterone synthesis and secretion, conserved biosystem (from KEGG)
      Aldosterone synthesis and secretion, conserved biosystemAldosterone is a steroid hormone synthesized in and secreted from the outer layer of the adrenal cortex, the zona glomerulosa. Aldosterone plays an important role in the regulation of systemic blood ...
    • Alzheimer's disease, organism-specific biosystem (from KEGG)
      Alzheimer's disease, organism-specific biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
    • Alzheimer's disease, conserved biosystem (from KEGG)
      Alzheimer's disease, conserved biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
    • Alzheimers Disease, organism-specific biosystem (from WikiPathways)
      Alzheimers Disease, organism-specific biosystemThis pathway displays current genes, proteolytic events and other processes associated with the progression of Alzheimer's disease. This pathway was adapted from KEGG on 10/7/2011. Note: mitochondria...
    • Amphetamine addiction, organism-specific biosystem (from KEGG)
      Amphetamine addiction, organism-specific biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
    • Amphetamine addiction, conserved biosystem (from KEGG)
      Amphetamine addiction, conserved biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
    • Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem (from KEGG)
      Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
    • Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem (from KEGG)
      Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
      Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
    • Calcium signaling pathway, organism-specific biosystem (from KEGG)
      Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Calcium signaling pathway, conserved biosystem (from KEGG)
      Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Cardiac conduction, organism-specific biosystem (from REACTOME)
      Cardiac conduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Cardiac muscle contraction, organism-specific biosystem (from KEGG)
      Cardiac muscle contraction, organism-specific biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
    • Cardiac muscle contraction, conserved biosystem (from KEGG)
      Cardiac muscle contraction, conserved biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
    • Cholinergic synapse, organism-specific biosystem (from KEGG)
      Cholinergic synapse, organism-specific biosystemAcetylcholine (ACh) is a neurotransmitter widely distributed in the central (and also peripheral, autonomic and enteric) nervous system (CNS). In the CNS, ACh facilitates many functions, such as lear...
    • Circadian entrainment, organism-specific biosystem (from KEGG)
      Circadian entrainment, organism-specific biosystemCircadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhy...
    • Circadian entrainment, conserved biosystem (from KEGG)
      Circadian entrainment, conserved biosystemCircadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhy...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Dilated cardiomyopathy, organism-specific biosystem (from KEGG)
      Dilated cardiomyopathy, organism-specific biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
    • Dilated cardiomyopathy, conserved biosystem (from KEGG)
      Dilated cardiomyopathy, conserved biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
    • Dopaminergic synapse, organism-specific biosystem (from KEGG)
      Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • Dopaminergic synapse, conserved biosystem (from KEGG)
      Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • GABAergic synapse, organism-specific biosystem (from KEGG)
      GABAergic synapse, organism-specific biosystemGamma aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian central nervous system (CNS). When released in the synaptic cleft, GABA binds to three major classes o...
    • GABAergic synapse, conserved biosystem (from KEGG)
      GABAergic synapse, conserved biosystemGamma aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian central nervous system (CNS). When released in the synaptic cleft, GABA binds to three major classes o...
    • Glutamatergic synapse, organism-specific biosystem (from KEGG)
      Glutamatergic synapse, organism-specific biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
    • Glutamatergic synapse, conserved biosystem (from KEGG)
      Glutamatergic synapse, conserved biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
    • GnRH signaling pathway, organism-specific biosystem (from KEGG)
      GnRH signaling pathway, organism-specific biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
    • GnRH signaling pathway, conserved biosystem (from KEGG)
      GnRH signaling pathway, conserved biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
    • Hypertrophic cardiomyopathy (HCM), organism-specific biosystem (from KEGG)
      Hypertrophic cardiomyopathy (HCM), organism-specific biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
    • Hypertrophic cardiomyopathy (HCM), conserved biosystem (from KEGG)
      Hypertrophic cardiomyopathy (HCM), conserved biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
    • Insulin secretion, organism-specific biosystem (from KEGG)
      Insulin secretion, organism-specific biosystemPancreatic beta cells are specialised endocrine cells that continuously sense the levels of blood sugar and other fuels and, in response, secrete insulin to maintain normal fuel homeostasis. Glucose-...
    • Integration of energy metabolism, organism-specific biosystem (from REACTOME)
      Integration of energy metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Long-term potentiation, organism-specific biosystem (from KEGG)
      Long-term potentiation, organism-specific biosystemHippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippo...
    • Long-term potentiation, conserved biosystem (from KEGG)
      Long-term potentiation, conserved biosystemHippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippo...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Muscle contraction, organism-specific biosystem (from REACTOME)
      Muscle contraction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • NCAM signaling for neurite out-growth, organism-specific biosystem (from REACTOME)
      NCAM signaling for neurite out-growth, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • NCAM1 interactions, organism-specific biosystem (from REACTOME)
      NCAM1 interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Oxytocin signaling pathway, organism-specific biosystem (from KEGG)
      Oxytocin signaling pathway, organism-specific biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
    • Oxytocin signaling pathway, conserved biosystem (from KEGG)
      Oxytocin signaling pathway, conserved biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
    • Phase 0 - rapid depolarisation, organism-specific biosystem (from REACTOME)
      Phase 0 - rapid depolarisation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Phase 2 - plateau phase, organism-specific biosystem (from REACTOME)
      Phase 2 - plateau phase, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Regulation of insulin secretion, organism-specific biosystem (from REACTOME)
      Regulation of insulin secretion, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Renin secretion, organism-specific biosystem (from KEGG)
      Renin secretion, organism-specific biosystemThe aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. R...
    • Renin secretion, conserved biosystem (from KEGG)
      Renin secretion, conserved biosystemThe aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. R...
    • Retrograde endocannabinoid signaling, organism-specific biosystem (from KEGG)
      Retrograde endocannabinoid signaling, organism-specific biosystemEndogenous cannabinoids (endocannabinoids) serve as retrograde messengers at synapses in various regions of the brain. The family of endocannabinoids includes at least five derivatives of arachidonic...
    • Retrograde endocannabinoid signaling, conserved biosystem (from KEGG)
      Retrograde endocannabinoid signaling, conserved biosystemEndogenous cannabinoids (endocannabinoids) serve as retrograde messengers at synapses in various regions of the brain. The family of endocannabinoids includes at least five derivatives of arachidonic...
    • Serotonergic synapse, organism-specific biosystem (from KEGG)
      Serotonergic synapse, organism-specific biosystemSerotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endoc...
    • Taste transduction, organism-specific biosystem (from KEGG)
      Taste transduction, organism-specific biosystemFive basic tastes are recognized by humans and most other animals - bitter, sweet, sour, salty and umami. In vertebrates, taste stimuli are detected by taste receptor cells (TRCs). At least three dis...
    • Taste transduction, conserved biosystem (from KEGG)
      Taste transduction, conserved biosystemFive basic tastes are recognized by humans and most other animals - bitter, sweet, sour, salty and umami. In vertebrates, taste stimuli are detected by taste receptor cells (TRCs). At least three dis...
    • Type II diabetes mellitus, organism-specific biosystem (from KEGG)
      Type II diabetes mellitus, organism-specific biosystemInsulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Ser...
    • Type II diabetes mellitus, conserved biosystem (from KEGG)
      Type II diabetes mellitus, conserved biosystemInsulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Ser...
    • Vascular smooth muscle contraction, organism-specific biosystem (from KEGG)
      Vascular smooth muscle contraction, organism-specific biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
    • Vascular smooth muscle contraction, conserved biosystem (from KEGG)
      Vascular smooth muscle contraction, conserved biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
    • cAMP signaling pathway, organism-specific biosystem (from KEGG)
      cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
    • cAMP signaling pathway, conserved biosystem (from KEGG)
      cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
    • cGMP-PKG signaling pathway, organism-specific biosystem (from KEGG)
      cGMP-PKG signaling pathway, organism-specific biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
    • cGMP-PKG signaling pathway, conserved biosystem (from KEGG)
      cGMP-PKG signaling pathway, conserved biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • D930026N18Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    alpha-actinin binding ISO
    Inferred from Sequence Orthology
    more info
     
    calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    high voltage-gated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    high voltage-gated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    ion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    ion channel binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphatase 2A binding ISO
    Inferred from Sequence Orthology
    more info
     
    translation initiation factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    voltage-gated calcium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    voltage-gated calcium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    voltage-gated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    voltage-gated calcium channel activity TAS
    Traceable Author Statement
    more info
    PubMed 
    voltage-gated calcium channel activity involved in AV node cell action potential ISO
    Inferred from Sequence Orthology
    more info
     
    voltage-gated calcium channel activity involved in cardiac muscle cell action potential ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to voltage-gated calcium channel activity involved in cardiac muscle cell action potential ISO
    Inferred from Sequence Orthology
    more info
     
    voltage-gated ion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    adult walking behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    calcium ion import ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion regulated exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion transmembrane transport via high voltage-gated calcium channel ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    camera-type eye development ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac conduction ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac muscle cell action potential involved in contraction ISO
    Inferred from Sequence Orthology
    more info
     
    cellular calcium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic forelimb morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    growth hormone secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    heart development ISO
    Inferred from Sequence Orthology
    more info
     
    immune system development ISO
    Inferred from Sequence Orthology
    more info
     
    insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    membrane depolarization during AV node cell action potential ISO
    Inferred from Sequence Orthology
    more info
     
    membrane depolarization during action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    membrane depolarization during atrial cardiac muscle cell action potential ISO
    Inferred from Sequence Orthology
    more info
     
    membrane depolarization during cardiac muscle cell action potential ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of heart rate by cardiac conduction ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of organ growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of vasoconstriction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of ventricular cardiac muscle cell action potential ISO
    Inferred from Sequence Orthology
    more info
     
    smooth muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    smooth muscle contraction involved in micturition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    visual learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    L-type voltage-gated calcium channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    T-tubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    T-tubule ISO
    Inferred from Sequence Orthology
    more info
     
    T-tubule TAS
    Traceable Author Statement
    more info
    PubMed 
    Z disc IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Z disc ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with Z disc ISO
    Inferred from Sequence Orthology
    more info
     
    caveolar macromolecular signaling complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic shaft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    sarcolemma ISO
    Inferred from Sequence Orthology
    more info
     
    voltage-gated calcium channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    voltage-gated calcium channel complex TAS
    Traceable Author Statement
    more info
    PubMed 
    Preferred Names
    voltage-dependent L-type calcium channel subunit alpha-1C
    Names
    brain class C
    calcium channel voltage-dependent alpha1c subunit
    calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle
    neuronal voltage-gated calcium channel alpha 1C subunit
    skeletal muscle-specific calcium channel
    voltage-gated calcium channel subunit alpha Cav1.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159533.2NP_001153005.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform 2

      See identical proteins and their annotated locations for NP_001153005.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' exon, as compared to variant 1. The resulting isoform (2) has a shorter and different N-terminus, as compared to isoform 1.
      Source sequence(s)
      AB259049, AC036121, AC126453, AW047472
      Consensus CDS
      CCDS80590.1
      UniProtKB/Swiss-Prot
      Q01815
      UniProtKB/TrEMBL
      Q0PCR6
      Related
      ENSMUSP00000077433.8, OTTMUSP00000067926, ENSMUST00000078320.13, OTTMUST00000125197
      Conserved Domains (5) summary
      pfam00520
      Location:12361487
      Ion_trans; Ion transport protein
      pfam08763
      Location:15601631
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:16542086
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:14951558
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
      cl01503
      Location:202291
      TrbL; TrbL/VirB6 plasmid conjugal transfer protein
    2. NM_001159534.2NP_001153006.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an alternate 5' exon and an alternate internal exon in the CDS, as compared to variant 1. The resulting isoform (3) has a shorter and different N-terminus and a different internal segment, as compared to isoform 1.
      Source sequence(s)
      AB259049, AC036121, AC126453, AW047472, FM872409
      Consensus CDS
      CCDS80589.1
      UniProtKB/TrEMBL
      C7TQ57, F8WJL1, Q0PCR6
      Related
      ENSMUSP00000108410.3, OTTMUSP00000067948, ENSMUST00000112790.8, OTTMUST00000125232
      Conserved Domains (5) summary
      pfam00520
      Location:12361487
      Ion_trans; Ion transport protein
      pfam08763
      Location:15601631
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:16542086
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:14951558
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
      cl01503
      Location:202291
      TrbL; TrbL/VirB6 plasmid conjugal transfer protein
    3. NM_001159535.2NP_001153007.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has an alternate 5' exon and an alternate internal exon in the CDS, as compared to variant 1. The resulting isoform (4) has a shorter and different N-terminus and a shorter and different internal segment, as compared to isoform 1.
      Source sequence(s)
      AB259049, AC036121, AC126453, AW047472, FM872409
      UniProtKB/TrEMBL
      C7TQ57, Q0PCR6
      Conserved Domains (5) summary
      pfam00520
      Location:12361485
      Ion_trans; Ion transport protein
      pfam08763
      Location:15581629
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:16522084
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:14931556
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
      cl01503
      Location:202291
      TrbL; TrbL/VirB6 plasmid conjugal transfer protein
    4. NM_001255997.2NP_001242926.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform 5

      See identical proteins and their annotated locations for NP_001242926.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 5, which is the same length as isoform 1.
      Source sequence(s)
      AC036121, AK052162, FM872409
      Consensus CDS
      CCDS80593.1
      UniProtKB/TrEMBL
      C7TQ57
      Related
      ENSMUSP00000141033.1, OTTMUSP00000067923, ENSMUST00000187940.6, OTTMUST00000125177
      Conserved Domains (5) summary
      pfam00520
      Location:12661517
      Ion_trans; Ion transport protein
      pfam08763
      Location:15901661
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:16842116
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:15251588
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
      cl01503
      Location:232321
      TrbL; TrbL/VirB6 plasmid conjugal transfer protein
    5. NM_001255998.2NP_001242927.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 6, which is longer than isoform 1.
      Source sequence(s)
      AC036121, AC127328, AK052162, FM872410
      Consensus CDS
      CCDS80595.1
      UniProtKB/TrEMBL
      A0A087WSE7, C7TQ58
      Related
      ENSMUSP00000141015.1, OTTMUSP00000067973, ENSMUST00000190285.1, OTTMUST00000125300
      Conserved Domains (5) summary
      pfam00520
      Location:12911542
      Ion_trans; Ion transport protein
      pfam08763
      Location:16151686
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:17092141
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:15501613
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
      cl01503
      Location:232321
      TrbL; TrbL/VirB6 plasmid conjugal transfer protein
    6. NM_001255999.2NP_001242928.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform 7

      See identical proteins and their annotated locations for NP_001242928.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 7, which is the same length as isoform 1.
      Source sequence(s)
      AC036121, AK052162, FM872411
      Consensus CDS
      CCDS80594.1
      UniProtKB/TrEMBL
      C7TQ59
      Related
      ENSMUSP00000140961.1, OTTMUSP00000067974, ENSMUST00000187474.6, OTTMUST00000125301
      Conserved Domains (5) summary
      pfam00520
      Location:12661517
      Ion_trans; Ion transport protein
      pfam08763
      Location:15901661
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:16842116
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:15251588
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
      cl01503
      Location:232321
      TrbL; TrbL/VirB6 plasmid conjugal transfer protein
    7. NM_001256000.2NP_001242929.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform 8

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at an alternate AUG and result in an isoform (8) that is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC036121, AC126453, AC127328, FM872412
      Consensus CDS
      CCDS80588.1
      UniProtKB/TrEMBL
      A0A087WS40, C7TQ60
      Related
      ENSMUSP00000140886.1, OTTMUSP00000068063, ENSMUST00000188106.6, OTTMUST00000125717
      Conserved Domains (5) summary
      pfam00520
      Location:12611501
      Ion_trans; Ion transport protein
      pfam08763
      Location:15741645
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:16682100
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:15091572
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
      cl01503
      Location:202291
      TrbL; TrbL/VirB6 plasmid conjugal transfer protein
    8. NM_001256001.2NP_001242930.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform 9

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at an alternate AUG and result in an isoform (9) that is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC036121, AC126453, AC127328, FM872413
      UniProtKB/TrEMBL
      C7TQ61
      Conserved Domains (5) summary
      pfam00520
      Location:12641504
      Ion_trans; Ion transport protein
      pfam08763
      Location:15771648
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:16712103
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:15121575
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
      cl01503
      Location:202291
      TrbL; TrbL/VirB6 plasmid conjugal transfer protein
    9. NM_001256002.2NP_001242931.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform 10

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at an alternate AUG and result in an isoform (10) that is longer and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC036121, AC126453, AC127328, FM872414
      Consensus CDS
      CCDS80587.1
      UniProtKB/TrEMBL
      C7TQ62, F7C376
      Related
      ENSMUSP00000108413.4, OTTMUSP00000067978, ENSMUST00000112793.9, OTTMUST00000125322
      Conserved Domains (5) summary
      pfam00520
      Location:141416
      Ion_trans; Ion transport protein
      pfam08763
      Location:16431714
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:17372169
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:15781641
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
      cl01503
      Location:202291
      TrbL; TrbL/VirB6 plasmid conjugal transfer protein
    10. NM_001290335.1NP_001277264.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform 11

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11) contains an alternate 5'-terminal exon, lacks part of the 5' coding region, uses a downstream start codon, and has multiple coding region differences, compared to variant 1. The encoded isoform (11) is shorter, compared to isoform 1.
      Source sequence(s)
      AC036121, AC127328, FM872412
      Consensus CDS
      CCDS71821.1
      UniProtKB/TrEMBL
      C7TQ60
      Related
      ENSMUSP00000108444.2, ENSMUST00000112825.8
      Conserved Domains (4) summary
      pfam00520
      Location:9771217
      Ion_trans; Ion transport protein
      pfam08763
      Location:12901361
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:13841816
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:12251288
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    11. NM_009781.4NP_033911.2  voltage-dependent L-type calcium channel subunit alpha-1C isoform 1

      See identical proteins and their annotated locations for NP_033911.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AB259049, AC036121, AK052162
      Consensus CDS
      CCDS80592.1
      UniProtKB/TrEMBL
      Q0PCR6
      Related
      ENSMUSP00000140056.1, OTTMUSP00000067922, ENSMUST00000186889.6, OTTMUST00000125176
      Conserved Domains (5) summary
      pfam00520
      Location:12661517
      Ion_trans; Ion transport protein
      pfam08763
      Location:15901661
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:16842116
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:15251588
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
      cl01503
      Location:232321
      TrbL; TrbL/VirB6 plasmid conjugal transfer protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      118587240..119197496 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505443.3XP_006505506.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X28

      Conserved Domains (5) summary
      pfam00520
      Location:12661506
      Ion_trans; Ion transport protein
      pfam08763
      Location:15791650
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:16732105
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:15141577
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
      cl01503
      Location:232321
      TrbL; TrbL/VirB6 plasmid conjugal transfer protein
    2. XM_006505436.3XP_006505499.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X22

      Conserved Domains (5) summary
      pfam00520
      Location:12661517
      Ion_trans; Ion transport protein
      pfam08763
      Location:15901661
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:16842116
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:15251588
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
      cl01503
      Location:232321
      TrbL; TrbL/VirB6 plasmid conjugal transfer protein
    3. XM_006505438.3XP_006505501.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X24

      Related
      ENSMUSP00000140415.1, OTTMUSP00000068074, ENSMUST00000188078.6, OTTMUST00000125730
      Conserved Domains (5) summary
      pfam00520
      Location:12661517
      Ion_trans; Ion transport protein
      pfam08763
      Location:15901661
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:16842116
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:15251588
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
      cl01503
      Location:232321
      TrbL; TrbL/VirB6 plasmid conjugal transfer protein
    4. XM_006505430.3XP_006505493.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X17

      Related
      ENSMUSP00000140220.1, OTTMUSP00000068076, ENSMUST00000189520.6, OTTMUST00000125736
      Conserved Domains (5) summary
      pfam00520
      Location:12661534
      Ion_trans; Ion transport protein
      pfam08763
      Location:16071678
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:17012133
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:15421605
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
      cl01503
      Location:232321
      TrbL; TrbL/VirB6 plasmid conjugal transfer protein
    5. XM_006505442.3XP_006505505.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X30

      Conserved Domains (5) summary
      pfam00520
      Location:12661506
      Ion_trans; Ion transport protein
      pfam08763
      Location:15791650
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:16732105
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:15141577
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
      cl01503
      Location:232321
      TrbL; TrbL/VirB6 plasmid conjugal transfer protein
    6. XM_006505434.3XP_006505497.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X23

      Conserved Domains (5) summary
      pfam00520
      Location:12661517
      Ion_trans; Ion transport protein
      pfam08763
      Location:15901661
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:16842116
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:15251588
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
      cl01503
      Location:232321
      TrbL; TrbL/VirB6 plasmid conjugal transfer protein
    7. XM_006505437.3XP_006505500.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X25

      Conserved Domains (5) summary
      pfam00520
      Location:12661517
      Ion_trans; Ion transport protein
      pfam08763
      Location:15901661
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:16842116
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:15251588
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
      cl01503
      Location:232321
      TrbL; TrbL/VirB6 plasmid conjugal transfer protein
    8. XM_006505426.3XP_006505489.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X12

      Related
      ENSMUSP00000139855.1, OTTMUSP00000068075, ENSMUST00000189389.6, OTTMUST00000125733
      Conserved Domains (5) summary
      pfam00520
      Location:12661545
      Ion_trans; Ion transport protein
      pfam08763
      Location:16181689
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:17122144
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:15531616
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
      cl01503
      Location:232321
      TrbL; TrbL/VirB6 plasmid conjugal transfer protein
    9. XM_006505418.3XP_006505481.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X35

      Related
      ENSMUSP00000140693.1, OTTMUSP00000068077, ENSMUST00000187317.6, OTTMUST00000125737
      Conserved Domains (5) summary
      pfam00520
      Location:12861565
      Ion_trans; Ion transport protein
      pfam08763
      Location:16381709
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:17322164
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:15731636
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
      cl01503
      Location:232321
      TrbL; TrbL/VirB6 plasmid conjugal transfer protein
    10. XM_011241193.2XP_011239495.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X37

      Conserved Domains (5) summary
      pfam00520
      Location:12691509
      Ion_trans; Ion transport protein
      pfam08763
      Location:15821653
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:16762108
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:15171580
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
      cl01503
      Location:232321
      TrbL; TrbL/VirB6 plasmid conjugal transfer protein
    11. XM_017321361.1XP_017176850.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X10

    12. XM_006505440.3XP_006505503.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X27

      Conserved Domains (5) summary
      pfam00520
      Location:12711511
      Ion_trans; Ion transport protein
      pfam08763
      Location:15841655
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:16782110
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:15191582
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
      cl01503
      Location:232321
      TrbL; TrbL/VirB6 plasmid conjugal transfer protein
    13. XM_006505427.3XP_006505490.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X16

      Related
      ENSMUSP00000140341.1, OTTMUSP00000067955, ENSMUST00000187386.6, OTTMUST00000125265
      Conserved Domains (5) summary
      pfam00520
      Location:12911542
      Ion_trans; Ion transport protein
      pfam08763
      Location:16151686
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:17092141
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:15501613
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
      cl01503
      Location:232321
      TrbL; TrbL/VirB6 plasmid conjugal transfer protein
    14. XM_006505432.3XP_006505495.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X20

      Conserved Domains (5) summary
      pfam00520
      Location:12911531
      Ion_trans; Ion transport protein
      pfam08763
      Location:16041675
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:16982130
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:15391602
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
      cl01503
      Location:232321
      TrbL; TrbL/VirB6 plasmid conjugal transfer protein
    15. XM_017321356.1XP_017176845.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X2

    16. XM_006505439.3XP_006505502.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X26

      Conserved Domains (5) summary
      pfam00520
      Location:12661515
      Ion_trans; Ion transport protein
      pfam08763
      Location:15881659
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:16822114
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:15231586
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
      cl01503
      Location:232321
      TrbL; TrbL/VirB6 plasmid conjugal transfer protein
    17. XM_006505441.3XP_006505504.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X29

      Conserved Domains (5) summary
      pfam00520
      Location:12661506
      Ion_trans; Ion transport protein
      pfam08763
      Location:15791650
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:16732105
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:15141577
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
      cl01503
      Location:232321
      TrbL; TrbL/VirB6 plasmid conjugal transfer protein
    18. XM_011241192.2XP_011239494.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X36

      Conserved Domains (5) summary
      pfam00520
      Location:12691509
      Ion_trans; Ion transport protein
      pfam08763
      Location:15821653
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:16762108
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:15171580
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
      cl01503
      Location:232321
      TrbL; TrbL/VirB6 plasmid conjugal transfer protein
    19. XM_017321360.1XP_017176849.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X9

    20. XM_017321358.1XP_017176847.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X5

    21. XM_006505415.3XP_006505478.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X6

      Conserved Domains (5) summary
      pfam00520
      Location:12911570
      Ion_trans; Ion transport protein
      pfam08763
      Location:16431714
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:17372169
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:15781641
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
      cl01503
      Location:232321
      TrbL; TrbL/VirB6 plasmid conjugal transfer protein
    22. XM_011241184.2XP_011239486.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X8

      Conserved Domains (5) summary
      pfam00520
      Location:12741553
      Ion_trans; Ion transport protein
      pfam08763
      Location:16261697
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:17202152
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:15611624
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
      cl01503
      Location:232321
      TrbL; TrbL/VirB6 plasmid conjugal transfer protein
    23. XM_017321364.1XP_017176853.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X15

    24. XM_011241185.2XP_011239487.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X11

      Conserved Domains (5) summary
      pfam00520
      Location:12941545
      Ion_trans; Ion transport protein
      pfam08763
      Location:16181689
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:17122144
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:15531616
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
      cl01503
      Location:232321
      TrbL; TrbL/VirB6 plasmid conjugal transfer protein
    25. XM_011241186.2XP_011239488.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X18

      Conserved Domains (5) summary
      pfam00520
      Location:12941534
      Ion_trans; Ion transport protein
      pfam08763
      Location:16071678
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:17012133
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:15421605
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
      cl01503
      Location:232321
      TrbL; TrbL/VirB6 plasmid conjugal transfer protein
    26. XM_017321362.1XP_017176851.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X13

    27. XM_017321357.1XP_017176846.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X4

    28. XM_017321359.1XP_017176848.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X7

    29. XM_011241175.2XP_011239477.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X1

      Conserved Domains (5) summary
      pfam00520
      Location:12941573
      Ion_trans; Ion transport protein
      pfam08763
      Location:16461717
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:17402172
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:15811644
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
      cl01503
      Location:232321
      TrbL; TrbL/VirB6 plasmid conjugal transfer protein
    30. XM_011241187.2XP_011239489.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X19

      Conserved Domains (5) summary
      pfam00520
      Location:12941534
      Ion_trans; Ion transport protein
      pfam08763
      Location:16071678
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:17012133
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:15421605
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
      cl01503
      Location:232321
      TrbL; TrbL/VirB6 plasmid conjugal transfer protein
    31. XM_011241176.2XP_011239478.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X3

      Conserved Domains (5) summary
      pfam00520
      Location:12941573
      Ion_trans; Ion transport protein
      pfam08763
      Location:16461717
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:17402172
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:15811644
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
      cl01503
      Location:232321
      TrbL; TrbL/VirB6 plasmid conjugal transfer protein
    32. XM_006505435.3XP_006505498.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X21

      Conserved Domains (5) summary
      pfam00520
      Location:12661517
      Ion_trans; Ion transport protein
      pfam08763
      Location:15901661
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:16842116
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:15251588
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
      cl01503
      Location:232321
      TrbL; TrbL/VirB6 plasmid conjugal transfer protein
    33. XM_017321363.1XP_017176852.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X14

    34. XM_017321365.1XP_017176854.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X31

    35. XM_017321367.1XP_017176856.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X32

    36. XM_017321369.1XP_017176858.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X34

    37. XM_017321368.1XP_017176857.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X33

    38. XM_017321366.1XP_017176855.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X32

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