Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    Actn4 actinin alpha 4 [ Mus musculus (house mouse) ]

    Gene ID: 60595, updated on 4-Jun-2017
    Official Symbol
    Actn4provided by MGI
    Official Full Name
    actinin alpha 4provided by MGI
    Primary source
    MGI:MGI:1890773
    See related
    Ensembl:ENSMUSG00000054808 Vega:OTTMUSG00000016983
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C77391
    Orthologs
    Location:
    7; 7 B1
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (28893248..28962354, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (29678273..29747299, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene lectin, galactose binding, soluble 7 Neighboring gene predicted gene 10648 Neighboring gene calpain 12 Neighboring gene predicted gene, 38978 Neighboring gene eukaryotic translation initiation factor 3, subunit K Neighboring gene mitogen-activated protein kinase kinase kinase kinase 1

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Adherens junction, organism-specific biosystem (from KEGG)
      Adherens junction, organism-specific biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Adherens junction, conserved biosystem (from KEGG)
      Adherens junction, conserved biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Amoebiasis, organism-specific biosystem (from KEGG)
      Amoebiasis, organism-specific biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
    • Amoebiasis, conserved biosystem (from KEGG)
      Amoebiasis, conserved biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
      Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Leukocyte transendothelial migration, conserved biosystem (from KEGG)
      Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
      Platelet activation, signaling and aggregation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Platelet degranulation, organism-specific biosystem (from REACTOME)
      Platelet degranulation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • PodNet: protein-protein interactions in the podocyte, organism-specific biosystem (from WikiPathways)
      PodNet: protein-protein interactions in the podocyte, organism-specific biosystemPodNet is a manually curated network of protein-protein interactions occurring in the podocyte.
    • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
      Regulation of actin cytoskeleton, organism-specific biosystem
      Regulation of actin cytoskeleton
    • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
      Regulation of actin cytoskeleton, conserved biosystem
      Regulation of actin cytoskeleton
    • Response to elevated platelet cytosolic Ca2+, organism-specific biosystem (from REACTOME)
      Response to elevated platelet cytosolic Ca2+, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Striated Muscle Contraction, organism-specific biosystem (from WikiPathways)
      Striated Muscle Contraction, organism-specific biosystem
      Striated Muscle Contraction
    • Systemic lupus erythematosus, organism-specific biosystem (from KEGG)
      Systemic lupus erythematosus, organism-specific biosystemSystemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by the production of IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and cert...
    • Systemic lupus erythematosus, conserved biosystem (from KEGG)
      Systemic lupus erythematosus, conserved biosystemSystemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by the production of IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and cert...
    • Tight junction, organism-specific biosystem (from KEGG)
      Tight junction, organism-specific biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
    • Tight junction, conserved biosystem (from KEGG)
      Tight junction, conserved biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
    • Viral carcinogenesis, organism-specific biosystem (from KEGG)
      Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
    • Viral carcinogenesis, conserved biosystem (from KEGG)
      Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
    • XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
      XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC102374

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    actin filament binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    ion channel binding ISO
    Inferred from Sequence Orthology
    more info
     
    ligand-dependent nuclear receptor transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoside binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein N-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity TAS
    Traceable Author Statement
    more info
    PubMed 
    retinoic acid receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    actin filament bundle assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    bicellular tight junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cellular component movement IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
     
    peroxisome proliferator activated receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of NIK/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cellular component movement IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cellular component movement IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cellular component movement ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of pinocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein localization to bicellular tight junction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of nucleic acid-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    retinoic acid receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    transport IEA
    Inferred from Electronic Annotation
    more info
     
    vesicle transport along actin filament ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Z disc IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cortical cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    pseudopodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    stress fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with stress fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with stress fiber ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    alpha-actinin-4
    Names
    F-actin cross-linking protein
    non-muscle alpha-actinin 4

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021895.2NP_068695.1  alpha-actinin-4

      See identical proteins and their annotated locations for NP_068695.1

      Status: PROVISIONAL

      Source sequence(s)
      AJ289242
      Consensus CDS
      CCDS21061.1
      UniProtKB/Swiss-Prot
      P57780
      UniProtKB/TrEMBL
      Q3ULT2
      Related
      ENSMUSP00000066068.7, OTTMUSP00000018457, ENSMUST00000068045.13, OTTMUST00000041188
      Conserved Domains (6) summary
      cd00014
      Location:165269
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00051
      Location:770837
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:415641
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00307
      Location:52150
      CH; Calponin homology (CH) domain
      pfam08726
      Location:842908
      EFhand_Ca_insen; Ca2+ insensitive EF hand
      pfam13499
      Location:772836
      EF-hand_7; EF-hand domain pair

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      28893248..28962354 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540255.3XP_006540318.1  alpha-actinin-4 isoform X2

      Conserved Domains (6) summary
      cd00014
      Location:165269
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00051
      Location:770832
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:415641
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00307
      Location:52150
      CH; Calponin homology (CH) domain
      pfam08726
      Location:837903
      EFhand_Ca_insen; Ca2+ insensitive EF hand
      pfam13499
      Location:772831
      EF-hand_7; EF-hand domain pair
    2. XM_006540257.2XP_006540320.1  alpha-actinin-4 isoform X4

      Related
      ENSMUSP00000151028.1, OTTMUSP00000078886, ENSMUST00000217157.1, OTTMUST00000152138
      Conserved Domains (5) summary
      cd00014
      Location:165269
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00051
      Location:770859
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:415641
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00307
      Location:52150
      CH; Calponin homology (CH) domain
      pfam08726
      Location:864930
      EFhand_Ca_insen; Ca2+ insensitive EF hand
    3. XM_006540256.3XP_006540319.1  alpha-actinin-4 isoform X3

      Conserved Domains (6) summary
      cd00014
      Location:165269
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00051
      Location:770832
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:415641
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00307
      Location:52150
      CH; Calponin homology (CH) domain
      pfam08726
      Location:837903
      EFhand_Ca_insen; Ca2+ insensitive EF hand
      pfam13499
      Location:772831
      EF-hand_7; EF-hand domain pair
    4. XM_006540254.3XP_006540317.1  alpha-actinin-4 isoform X1

      Conserved Domains (6) summary
      cd00014
      Location:165269
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00051
      Location:770837
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:415641
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00307
      Location:52150
      CH; Calponin homology (CH) domain
      pfam08726
      Location:842908
      EFhand_Ca_insen; Ca2+ insensitive EF hand
      pfam13499
      Location:772836
      EF-hand_7; EF-hand domain pair
    Support Center