Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    HRD1 E3 ubiquitin-protein ligase HRD1 [ Saccharomyces cerevisiae S288c ]

    Gene ID: 854149, updated on 20-Apr-2017
    Gene symbol
    HRD1
    Gene description
    E3 ubiquitin-protein ligase HRD1
    Primary source
    SGD:S000005373
    Locus tag
    YOL013C
    Gene type
    protein coding
    RNA name
    E3 ubiquitin-protein ligase HRD1
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    DER3
    See HRD1 in Map Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (301380..303035, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene tRNA Neighboring gene histone H2AZ Neighboring gene lysophospholipase

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
      Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
      Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase activity involved in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin-protein transferase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    ubiquitin-protein transferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ubiquitin-specific protease binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    endoplasmic reticulum unfolded protein response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fungal-type cell wall organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein autoubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    retrograde protein transport, ER to cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    retrograde protein transport, ER to cytosol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ubiquitin-dependent ERAD pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ubiquitin-dependent ERAD pathway IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    Hrd1p ubiquitin ligase ERAD-L complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Hrd1p ubiquitin ligase ERAD-M complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane ISM
    Inferred from Sequence Model
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Names
    E3 ubiquitin-protein ligase HRD1
    NP_014630.1
    • Ubiquitin-protein ligase involved in ER-associated degradation (ERAD) of misfolded proteins; upon autoubiquitination triggers retrotranslocation of misfolded proteins to cytosol for degradation; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; likely plays a general role in targeting proteins that persistently associate with and potentially obstruct the ER-localized translocon

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      301380..303035 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183267.1NP_014630.1  TPA: E3 ubiquitin-protein ligase HRD1 [Saccharomyces cerevisiae S288c]

      See identical proteins and their annotated locations for NP_014630.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q08109
      Conserved Domains (2) summary
      COG5243
      Location:5551
      HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
      pfam13639
      Location:347400
      zf-RING_2; Ring finger domain
    Support Center