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    CYP2J2 cytochrome P450 family 2 subfamily J member 2 [ Homo sapiens (human) ]

    Gene ID: 1573, updated on 3-Dec-2017
    Official Symbol
    CYP2J2provided by HGNC
    Official Full Name
    cytochrome P450 family 2 subfamily J member 2provided by HGNC
    Primary source
    HGNC:HGNC:2634
    See related
    Ensembl:ENSG00000134716 MIM:601258; Vega:OTTHUMG00000008991
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CPJ2; CYPIIJ2
    Summary
    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is thought to be the predominant enzyme responsible for epoxidation of endogenous arachidonic acid in cardiac tissue. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016]
    Expression
    Biased expression in small intestine (RPKM 44.5), heart (RPKM 35.2) and 10 other tissues See more
    Orthologs
    Location:
    1p32.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 1 NC_000001.11 (59893308..59926798, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (60358980..60392445, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101926944 Neighboring gene uncharacterized LOC105378758 Neighboring gene hook microtubule tethering protein 1 Neighboring gene RNA, 7SL, cytoplasmic 475, pseudogene Neighboring gene chromosome 1 open reading frame 87

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    arachidonic acid 11,12-epoxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    arachidonic acid 14,15-epoxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    arachidonic acid epoxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    arachidonic acid epoxygenase activity TAS
    Traceable Author Statement
    more info
     
    aromatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    heme binding IEA
    Inferred from Electronic Annotation
    more info
     
    iron ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    linoleic acid epoxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    monooxygenase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    epoxygenase P450 pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    epoxygenase P450 pathway TAS
    Traceable Author Statement
    more info
     
    icosanoid metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    linoleic acid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of heart contraction TAS
    Traceable Author Statement
    more info
    PubMed 
    xenobiotic metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    organelle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    cytochrome P450 2J2
    Names
    arachidonic acid epoxygenase
    cytochrome P450, family 2, subfamily J, polypeptide 2
    cytochrome P450, subfamily IIJ (arachidonic acid epoxygenase) polypeptide 2
    flavoprotein-linked monooxygenase
    microsomal monooxygenase
    NP_000766.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007931.1 RefSeqGene

      Range
      4954..38444
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000775.3NP_000766.2  cytochrome P450 2J2

      See identical proteins and their annotated locations for NP_000766.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the protein-coding transcript.
      Source sequence(s)
      BC032594, BI457601
      Consensus CDS
      CCDS613.1
      UniProtKB/Swiss-Prot
      P51589
      Related
      ENSP00000360247.3, OTTHUMP00000010550, ENST00000371204.3, OTTHUMT00000024940
      Conserved Domains (1) summary
      pfam00067
      Location:44497
      p450; Cytochrome P450

    RNA

    1. NR_134981.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BC032594, BI457601, CD013972
      Related
      ENST00000466095.5
    2. NR_134982.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC113175, BC032594, BI457601, CD013973
      Related
      ENST00000469406.5

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p7 Primary Assembly

      Range
      59893308..59926798 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      60474448..60507938 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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