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    vif p23 [ Human immunodeficiency virus 1 ]

    Gene ID: 155459, updated on 5-Feb-2017
    Gene symbol
    vif
    Gene description
    p23
    Locus tag
    HIV1gp3
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Human immunodeficiency virus 1 (gb-acronym: HIV-1)
    Lineage
    Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; Lentivirus; Primate lentivirus group
    Sequence:
    NC_001802.1 (4587..5165)

    NC_001802.1Genomic Context describing neighboring genes Neighboring gene Gag-Pol Neighboring gene Pr55(Gag) Neighboring gene p15 Neighboring gene p14 Neighboring gene p19 Neighboring gene p16 Neighboring gene gp160; envelope glycoprotein Neighboring gene minus-strand-encoded antisense protein of unknown function; region is highly conserved and likely analogous to the HTLV-1 encoded, HBZ, a nuclear basic region leucine zipper (b-ZIP) protein

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    ATP-binding cassette sub-family E member 1 ABCE1 associates with PubMed
    ankyrin repeat and BTB/POZ domain-containing protein 2 ABTB2 upregulates PubMed
    A disintegrin and metalloproteinase with thrombospondin motifs 19 precursor ADAMTS19 downregulates PubMed
    A disintegrin and metalloproteinase with thrombospondin motifs 3 preproprotein ADAMTS3 upregulates PubMed
    gamma-adducin isoform b ADD3 downregulates PubMed
    alpha-hemoglobin-stabilizing protein AHSP upregulates PubMed
    single-stranded DNA cytosine deaminase isoform 1 AICDA inhibits PubMed
    A-kinase anchor protein 8-like isoform 1 AKAP8L interacts with PubMed
    activating molecule in BECN1-regulated autophagy protein 1 isoform 2 AMBRA1 interacts with PubMed
    DNA dC->dU-editing enzyme APOBEC-3A isoform a APOBEC3A relocalizes PubMed
    APOBEC3A downregulates PubMed
    APOBEC3A co-localizes with PubMed
    DNA dC->dU-editing enzyme APOBEC-3B isoform a APOBEC3B degrades PubMed
    APOBEC3B induces ubiquitination of PubMed
    APOBEC3B inhibited by PubMed
    APOBEC3B relocalizes PubMed
    APOBEC3B co-localizes with PubMed
    DNA dC->dU-editing enzyme APOBEC-3C APOBEC3C interacts with PubMed
    APOBEC3C interacts with PubMed
    APOBEC3C binds PubMed
    APOBEC3C downregulates PubMed
    APOBEC3C degrades PubMed
    APOBEC3C co-localizes with PubMed
    APOBEC3C relocalizes PubMed
    APOBEC3C interacts with PubMed
    APOBEC3C regulates PubMed
    APOBEC3C degrades PubMed
    APOBEC3C degrades PubMed
    APOBEC3C degrades PubMed
    DNA dC->dU-editing enzyme APOBEC-3D APOBEC3D interacts with PubMed
    APOBEC3D downregulates PubMed
    APOBEC3D inhibits PubMed
    APOBEC3D inhibited by PubMed
    APOBEC3D degrades PubMed
    APOBEC3D interacts with PubMed
    APOBEC3D degrades PubMed
    APOBEC3D inhibits PubMed
    APOBEC3D degrades PubMed
    DNA dC->dU-editing enzyme APOBEC-3F isoform a APOBEC3F interacts with PubMed
    APOBEC3F inhibits PubMed
    APOBEC3F inhibits PubMed
    APOBEC3F interacts with PubMed
    APOBEC3F degrades PubMed
    APOBEC3F disrupts PubMed
    APOBEC3F binds PubMed
    APOBEC3F downregulates PubMed
    APOBEC3F binds PubMed
    APOBEC3F inhibited by PubMed
    APOBEC3F binds PubMed
    APOBEC3F downregulates PubMed
    APOBEC3F degrades PubMed
    APOBEC3F binds PubMed
    APOBEC3F inhibits PubMed
    APOBEC3F interacts with PubMed
    APOBEC3F degrades PubMed
    APOBEC3F binds PubMed
    APOBEC3F degrades PubMed
    APOBEC3F degrades PubMed
    APOBEC3F degrades PubMed
    APOBEC3F interacts with PubMed
    APOBEC3F interacts with PubMed
    APOBEC3F interacts with PubMed
    APOBEC3F inhibits PubMed
    APOBEC3F inhibits PubMed
    APOBEC3F interacts with PubMed
    APOBEC3F co-localizes with PubMed
    APOBEC3F inhibits PubMed
    APOBEC3F interacts with PubMed
    APOBEC3F binds PubMed
    APOBEC3F degrades PubMed
    APOBEC3F binds PubMed
    APOBEC3F inhibits PubMed
    APOBEC3F interacts with PubMed
    APOBEC3F inhibits PubMed
    APOBEC3F inhibits PubMed
    APOBEC3F disrupts PubMed
    APOBEC3F disrupts PubMed
    APOBEC3F binds PubMed
    APOBEC3F inhibits PubMed
    APOBEC3F inhibits PubMed
    DNA dC->dU-editing enzyme APOBEC-3G APOBEC3G interacts with PubMed
    APOBEC3G interacts with PubMed
    APOBEC3G complexes with PubMed
    APOBEC3G binds PubMed
    APOBEC3G inhibits PubMed
    APOBEC3G binds PubMed
    APOBEC3G packages PubMed
    APOBEC3G antagonizes PubMed
    APOBEC3G degrades PubMed
    APOBEC3G interacts with PubMed
    APOBEC3G induces ubiquitination of PubMed
    APOBEC3G inhibits PubMed
    APOBEC3G inhibits PubMed
    APOBEC3G degrades PubMed
    APOBEC3G degrades PubMed
    APOBEC3G interacts with PubMed
    APOBEC3G degrades PubMed
    APOBEC3G interacts with PubMed
    APOBEC3G downregulates PubMed
    APOBEC3G inhibits PubMed
    APOBEC3G inhibits PubMed
    APOBEC3G interacts with PubMed
    APOBEC3G inhibits PubMed
    APOBEC3G disrupts PubMed
    APOBEC3G degrades PubMed
    APOBEC3G interacts with PubMed
    APOBEC3G degrades PubMed
    APOBEC3G inhibited by PubMed
    APOBEC3G interacts with PubMed
    APOBEC3G interacts with PubMed
    APOBEC3G degrades PubMed
    APOBEC3G disrupts PubMed
    APOBEC3G induces ubiquitination of PubMed
    APOBEC3G interacts with PubMed
    APOBEC3G inhibits PubMed
    APOBEC3G downregulates PubMed
    APOBEC3G interacts with PubMed
    APOBEC3G degrades PubMed
    APOBEC3G degrades PubMed
    APOBEC3G degrades PubMed
    APOBEC3G degrades PubMed
    APOBEC3G degrades PubMed
    APOBEC3G binds PubMed
    APOBEC3G interacts with PubMed
    APOBEC3G degrades PubMed
    APOBEC3G degrades PubMed
    APOBEC3G degrades PubMed
    APOBEC3G degrades PubMed
    APOBEC3G interacts with PubMed
    APOBEC3G degrades PubMed
    APOBEC3G interacts with PubMed
    APOBEC3G degrades PubMed
    APOBEC3G degrades PubMed
    APOBEC3G downregulates PubMed
    APOBEC3G interacts with PubMed
    APOBEC3G interacts with PubMed
    APOBEC3G binds PubMed
    APOBEC3G degrades PubMed
    APOBEC3G binds PubMed
    APOBEC3G inhibits PubMed
    APOBEC3G binds PubMed
    APOBEC3G binds PubMed
    APOBEC3G binds PubMed
    APOBEC3G inhibits PubMed
    APOBEC3G inhibits PubMed
    APOBEC3G degrades PubMed
    APOBEC3G degrades PubMed
    APOBEC3G interacts with PubMed
    APOBEC3G degrades PubMed
    APOBEC3G inhibits PubMed
    APOBEC3G interacts with PubMed
    APOBEC3G interacts with PubMed
    APOBEC3G interacts with PubMed
    APOBEC3G degrades PubMed
    APOBEC3G downregulates PubMed
    APOBEC3G interacts with PubMed
    APOBEC3G downregulates PubMed
    APOBEC3G binds PubMed
    APOBEC3G inhibits PubMed
    APOBEC3G degrades PubMed
    APOBEC3G inhibited by PubMed
    APOBEC3G interacts with PubMed
    APOBEC3G interacts with PubMed
    APOBEC3G degrades PubMed
    APOBEC3G binds PubMed
    APOBEC3G binds PubMed
    APOBEC3G binds PubMed
    APOBEC3G degrades PubMed
    APOBEC3G degrades PubMed
    APOBEC3G binds PubMed
    APOBEC3G inhibited by PubMed
    APOBEC3G degrades PubMed
    APOBEC3G degrades PubMed
    APOBEC3G degrades PubMed
    APOBEC3G inhibits PubMed
    APOBEC3G inhibits PubMed
    APOBEC3G interacts with PubMed
    APOBEC3G interacts with PubMed
    APOBEC3G interacts with PubMed
    APOBEC3G disrupts PubMed
    APOBEC3G inhibits PubMed
    APOBEC3G inhibits PubMed
    APOBEC3G inhibits PubMed
    APOBEC3G inhibits PubMed
    APOBEC3G degrades PubMed
    APOBEC3G downregulates PubMed
    APOBEC3G interacts with PubMed
    APOBEC3G inhibits PubMed
    APOBEC3G binds PubMed
    APOBEC3G binds PubMed
    APOBEC3G degrades PubMed
    DNA dC->dU-editing enzyme APOBEC-3H isoform SV-183 APOBEC3H inhibits PubMed
    APOBEC3H degrades PubMed
    APOBEC3H degrades PubMed
    APOBEC3H interacts with PubMed
    APOBEC3H inhibits PubMed
    APOBEC3H interacts with PubMed
    APOBEC3H downregulates PubMed
    APOBEC3H inhibited by PubMed
    APOBEC3H interacts with PubMed
    APOBEC3H induces ubiquitination of PubMed
    APOBEC3H inhibits PubMed
    APOBEC3H inhibits PubMed
    APOBEC3H inhibits PubMed
    APOBEC3H inhibits PubMed
    APOBEC3H degrades PubMed
    apolipoprotein L1 isoform a precursor APOL1 downregulated by PubMed
    APOL1 downregulated by PubMed
    amphiregulin preproprotein AREG upregulates PubMed
    cysteine protease ATG4A isoform a ATG4A interacts with PubMed
    cysteine protease ATG4B isoform a ATG4B interacts with PubMed
    cysteine protease ATG4C ATG4C interacts with PubMed
    cysteine protease ATG4D isoform 1 precursor ATG4D interacts with PubMed
    serine-protein kinase ATM ATM downregulates PubMed
    protein ATP1B4 isoform B ATP1B4 upregulates PubMed
    ataxin-1 ATXN1 upregulates PubMed
    galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 B3GAT1 upregulates PubMed
    large proline-rich protein BAG6 isoform a BAG6 interacts with PubMed
    bromodomain adjacent to zinc finger domain protein 2A isoform 1 BAZ2A downregulates PubMed
    nuclear nucleic acid-binding protein C1D C1D modulates PubMed
    complement C5 isoform 1 preproprotein C5 downregulates PubMed
    CDK5 and ABL1 enzyme substrate 1 isoform 1 CABLES1 upregulates PubMed
    calcyphosin-2 isoform 1 CAPS2 downregulates PubMed
    cation channel sperm-associated protein 3 CATSPER3 downregulates PubMed
    core-binding factor subunit beta isoform 2 CBFB interacts with PubMed
    CBFB requires PubMed
    CBFB interacts with PubMed
    CBFB complexes with PubMed
    CBFB stabilized by PubMed
    CBFB interacts with PubMed
    CBFB binds PubMed
    CBFB complexes with PubMed
    CBFB interacts with PubMed
    CBFB stabilized by PubMed
    CBFB disrupted by PubMed
    CBFB enhanced by PubMed
    CBFB binds PubMed
    CBFB complexes with PubMed
    CBFB binds PubMed
    CBFB complexes with PubMed
    CBFB interacts with PubMed
    CBFB complexes with PubMed
    CBFB interacts with PubMed
    CBFB complexes with PubMed
    CBFB binds PubMed
    CBFB enhanced by PubMed
    CBFB cooperates with PubMed
    CBFB interacts with PubMed
    CBFB complexes with PubMed
    CBFB interacts with PubMed
    CBFB induces ubiquitination of PubMed
    CBFB binds PubMed
    CBFB complexes with PubMed
    CBFB complexes with PubMed
    CBFB interacts with PubMed
    CBFB interacts with PubMed
    CBFB interacts with PubMed
    CBFB interacts with PubMed
    CBFB interacts with PubMed
    CBFB stabilized by PubMed
    CBFB interacts with PubMed
    CBFB interacts with PubMed
    CBFB binds PubMed
    CBFB interacts with PubMed
    C-C motif chemokine 1 precursor CCL1 downregulates PubMed
    cyclin-A1 isoform a CCNA1 upregulates PubMed
    G2/mitotic-specific cyclin-B1 CCNB1 inhibits PubMed
    C-C chemokine receptor type 4 CCR4 upregulates PubMed
    C-C chemokine receptor type 7 isoform a precursor CCR7 upregulates PubMed
    C-C chemokine receptor type 9 isoform B CCR9 downregulates PubMed
    vacuolar fusion protein CCZ1 homolog B CCZ1B downregulates PubMed
    CD226 antigen isoform a precursor CD226 downregulates PubMed
    CMRF35-like molecule 8 isoform 1 precursor CD300A downregulates PubMed
    T-cell surface glycoprotein CD4 isoform 1 precursor CD4 interacts with PubMed
    CD44 antigen isoform 1 precursor CD44 upregulates PubMed
    ubiquitin-conjugating enzyme E2 R1 CDC34 cooperates with PubMed
    cyclin-dependent kinase 1 isoform 1 CDK1 inhibits PubMed
    CDK1 inhibits PubMed
    cyclin-dependent kinase 9 CDK9 interacts with PubMed
    cyclin-dependent kinase inhibitor 1 isoform 1 CDKN1A upregulates PubMed
    CCAAT/enhancer-binding protein beta isoform a CEBPB enhanced by PubMed
    CCAAT/enhancer-binding protein epsilon CEBPE upregulates PubMed
    C-type lectin domain family 2 member D isoform 1 CLEC2D downregulates PubMed
    collectin-12 COLEC12 downregulates PubMed
    complement receptor type 2 isoform 2 precursor CR2 downregulates PubMed
    macrophage colony-stimulating factor 1 isoform a precursor CSF1 upregulates PubMed
    granulocyte-macrophage colony-stimulating factor precursor CSF2 upregulates PubMed
    cullin-2 isoform c CUL2 interacts with PubMed
    cullin-4A isoform 2 CUL4A interacts with PubMed
    cullin-5 CUL5 interacts with PubMed
    CUL5 interacts with PubMed
    CUL5 complexes with PubMed
    CUL5 complexes with PubMed
    CUL5 complexes with PubMed
    CUL5 interacts with PubMed
    CUL5 complexes with PubMed
    CUL5 binds PubMed
    CUL5 complexes with PubMed
    CUL5 interacts with PubMed
    CUL5 complexes with PubMed
    CUL5 complexes with PubMed
    CUL5 complexes with PubMed
    CUL5 interacts with PubMed
    CUL5 binds PubMed
    CUL5 interacts with PubMed
    CUL5 interacts with PubMed
    CUL5 interacts with PubMed
    CUL5 complexes with PubMed
    CUL5 interacts with PubMed
    CUL5 interacts with PubMed
    CUL5 requires PubMed
    CUL5 interacts with PubMed
    CUL5 interacts with PubMed
    CUL5 inhibited by PubMed
    CUL5 regulated by PubMed
    CUL5 interacts with PubMed
    CUL5 interacts with PubMed
    C-X-C chemokine receptor type 3 isoform 1 CXCR3 upregulates PubMed
    cytochrome P450 3A7 CYP3A7 downregulates PubMed
    DDB1- and CUL4-associated factor 11 isoform 1 DCAF11 interacts with PubMed
    7-dehydrocholesterol reductase DHCR7 upregulates PubMed
    ATP-dependent RNA helicase A DHX9 regulated by PubMed
    dnaJ homolog subfamily B member 2 isoform b DNAJB2 interacts with PubMed
    dnaJ homolog subfamily C member 7 isoform 1 DNAJC7 interacts with PubMed
    dual specificity protein phosphatase 1 DUSP1 upregulates PubMed
    egl nine homolog 1 EGLN1 downregulates PubMed
    interferon-induced, double-stranded RNA-activated protein kinase isoform a EIF2AK2 regulated by PubMed
    eukaryotic translation initiation factor 4E type 3 isoform b EIF4E3 upregulates PubMed
    transcription elongation factor B polypeptide 2 isoform a ELOB complexes with PubMed
    ELOB interacts with PubMed
    ELOB complexes with PubMed
    ELOB complexes with PubMed
    ELOB complexes with PubMed
    ELOB complexes with PubMed
    ELOB interacts with PubMed
    ELOB complexes with PubMed
    ELOB complexes with PubMed
    ELOB binds PubMed
    ELOB stabilized by PubMed
    ELOB interacts with PubMed
    ELOB interacts with PubMed
    ELOB enhanced by PubMed
    ELOB complexes with PubMed
    ELOB binds PubMed
    transcription elongation factor B polypeptide 1 isoform a ELOC interacts with PubMed
    ELOC complexes with PubMed
    ELOC interacts with PubMed
    ELOC interacts with PubMed
    ELOC complexes with PubMed
    ELOC complexes with PubMed
    ELOC interacts with PubMed
    ELOC complexes with PubMed
    ELOC interacts with PubMed
    ELOC interacts with PubMed
    ELOC complexes with PubMed
    ELOC complexes with PubMed
    ELOC binds PubMed
    ELOC enhanced by PubMed
    ELOC complexes with PubMed
    ELOC interacts with PubMed
    ELOC interacts with PubMed
    ELOC complexes with PubMed
    ELOC binds PubMed
    ERBB receptor feedback inhibitor 1 ERRFI1 downregulates PubMed
    proteinase-activated receptor 3 isoform 1 precursor F2RL2 downregulates PubMed
    tissue factor isoform 1 precursor F3 upregulates PubMed
    protein FAM26F isoform 1 FAM26F downregulates PubMed
    protein FAM49A FAM49A upregulates PubMed
    fibroblast growth factor-binding protein 2 precursor FGFBP2 downregulates PubMed
    fibroleukin precursor FGL2 downregulates PubMed
    fascin FSCN1 upregulates PubMed
    endothelial transcription factor GATA-2 isoform 1 GATA2 upregulates PubMed
    guanylate-binding protein 4 GBP4 upregulates PubMed
    guanylate-binding protein 5 GBP5 downregulates PubMed
    GDNF family receptor alpha-1 isoform a preproprotein GFRA1 downregulates PubMed
    GTPase IMAP family member 6 isoform 1 GIMAP6 downregulates PubMed
    GLIPR1-like protein 1 isoform 2 precursor GLIPR1L1 downregulates PubMed
    glycine receptor subunit beta isoform A precursor GLRB downregulates PubMed
    G-protein coupled receptor 183 GPR183 upregulates PubMed
    probable G-protein coupled receptor 52 GPR52 downregulates PubMed
    G-protein coupled receptor 55 GPR55 upregulates PubMed
    G protein pathway suppressor 2 GPS2 interacts with PubMed
    GRB2-related adapter protein isoform 1 GRAP downregulates PubMed
    glutathione S-transferase A4 GSTA4 downregulates PubMed
    granzyme B isoform 1 preproprotein GZMB upregulates PubMed
    GDH/6PGL endoplasmic bifunctional protein isoform 2 precursor H6PD downregulates PubMed
    tyrosine-protein kinase HCK isoform a HCK interacts with PubMed
    HCK inhibits PubMed
    histone deacetylase 3 HDAC3 interacts with PubMed
    histone deacetylase 6 isoform a HDAC6 interacts with PubMed
    HDAC6 degradation is mediated by PubMed
    HDAC6 inhibited by PubMed
    HDAC6 complexes with PubMed
    HDAC6 binds PubMed
    HDAC6 decreased by PubMed
    HLA class II histocompatibility antigen, DQ beta 1 chain isoform 1 precursor HLA-DQB1 downregulates PubMed
    major histocompatibility complex, class II, DR beta 1 precursor HLA-DRB1 interacts with PubMed
    heterogeneous nuclear ribonucleoproteins A2/B1 isoform A2 HNRNPA2B1 regulated by PubMed
    HNRNPA2B1 regulated by PubMed
    heterogeneous nuclear ribonucleoprotein F HNRNPF regulated by PubMed
    HNRNPF regulated by PubMed
    heterogeneous nuclear ribonucleoprotein H HNRNPH1 regulated by PubMed
    HNRNPH1 regulated by PubMed
    heat shock 70 kDa protein 4 HSPA4 interacts with PubMed
    E3 ubiquitin-protein ligase HUWE1 HUWE1 interacts with PubMed
    islet cell autoantigen 1 isoform a ICA1 downregulates PubMed
    interferon-induced protein with tetratricopeptide repeats 3 isoform a IFIT3 downregulates PubMed
    interferon-induced transmembrane protein 1 IFITM1 downregulated by PubMed
    interferon-induced transmembrane protein 2 IFITM2 downregulated by PubMed
    interferon-induced transmembrane protein 3 IFITM3 downregulated by PubMed
    IFITM3 downregulated by PubMed
    interferon alpha-1/13 precursor IFNA1 inhibited by PubMed
    interferon alpha-10 precursor IFNA10 inhibited by PubMed
    IFNA13 inhibited by PubMed
    interferon alpha-14 precursor IFNA14 inhibited by PubMed
    interferon alpha-16 precursor IFNA16 inhibited by PubMed
    interferon alpha-17 precursor IFNA17 inhibited by PubMed
    interferon alpha-2 precursor IFNA2 inhibited by PubMed
    interferon alpha-21 precursor IFNA21 inhibited by PubMed
    interferon alpha-4 precursor IFNA4 inhibited by PubMed
    interferon alpha-5 precursor IFNA5 inhibited by PubMed
    interferon alpha-6 precursor IFNA6 inhibited by PubMed
    interferon alpha-7 precursor IFNA7 inhibited by PubMed
    interferon alpha-8 precursor IFNA8 inhibited by PubMed
    interferon beta precursor IFNB1 inhibits PubMed
    interferon gamma precursor IFNG downregulates PubMed
    zinc finger protein Aiolos isoform 1 IKZF3 downregulates PubMed
    interleukin-10 precursor IL10 upregulates PubMed
    interleukin-23 receptor precursor IL23R upregulates PubMed
    interleukin-31 receptor subunit alpha isoform 1 IL31RA modulates PubMed
    interleukin-4 isoform 1 precursor IL4 upregulates PubMed
    interleukin-7 receptor subunit alpha precursor IL7R upregulates PubMed
    insulin-induced gene 1 protein isoform 1 INSIG1 upregulates PubMed
    interferon regulatory factor 1 IRF1 downregulates PubMed
    interferon regulatory factor 3 isoform 1 IRF3 induces cleavage of PubMed
    IRF3 degrades PubMed
    isthmin-1 precursor ISM1 upregulates PubMed
    E3 ubiquitin-protein ligase Itchy homolog isoform 2 ITCH binds PubMed
    integrin alpha-6 isoform b preproprotein ITGA6 downregulates PubMed
    KH domain-containing, RNA-binding, signal transduction-associated protein 3 KHDRBS3 upregulates PubMed
    sickle tail protein homolog isoform 1 KIAA1217 upregulates PubMed
    Krueppel-like factor 2 KLF2 downregulates PubMed
    lysine-rich nucleolar protein 1 isoform b KNOP1 downregulates PubMed
    low-density lipoprotein receptor isoform 1 precursor LDLR upregulates PubMed
    lipopolysaccharide-induced tumor necrosis factor-alpha factor isoform 1 LITAF upregulates PubMed
    LON peptidase N-terminal domain and RING finger protein 2 LONRF2 downregulates PubMed
    lymphocyte antigen 96 isoform 1 precursor LY96 upregulates PubMed
    mastermind-like protein 2 MAML2 downregulates PubMed
    mastermind-like domain-containing protein 1 isoform 2 MAMLD1 upregulates PubMed
    microtubule-associated protein 1B isoform 1 MAP1B downregulates PubMed
    microtubule-associated proteins 1A/1B light chain 3A isoform a MAP1LC3A binds PubMed
    MAP1LC3A binds PubMed
    MAP1LC3A interacts with PubMed
    microtubule-associated proteins 1A/1B light chain 3B MAP1LC3B binds PubMed
    MAP1LC3B binds PubMed
    MAP1LC3B interacts with PubMed
    microtubule-associated proteins 1A/1B light chain 3C MAP1LC3C binds PubMed
    MAP1LC3C binds PubMed
    MAP1LC3C interacts with PubMed
    mitogen-activated protein kinase kinase kinase 5 MAP3K5 inhibited by PubMed
    MAP3K5 inhibited by PubMed
    MAP3K5 inhibited by PubMed
    MAP3K5 binds PubMed
    MAP3K5 binds PubMed
    mitogen-activated protein kinase 1 MAPK1 phosphorylated by PubMed
    mitogen-activated protein kinase 3 isoform 1 MAPK3 phosphorylated by PubMed
    E3 ubiquitin-protein ligase Mdm2 isoform a MDM2 interacts with PubMed
    MDM2 degraded by PubMed
    MDM2 binds PubMed
    MDM2 inhibits PubMed
    neprilysin MME upregulates PubMed
    meiosis-specific nuclear structural protein 1 MNS1 downregulates PubMed
    mitochondrial peptide methionine sulfoxide reductase isoform a precursor MSRA downregulates PubMed
    mevalonate kinase isoform a MVK upregulates PubMed
    nuclear receptor corepressor 1 isoform 1 NCOR1 interacts with PubMed
    E3 ubiquitin-protein ligase NEDD4 isoform 1 NEDD4 binds PubMed
    NEDD8 precursor NEDD8 complexes with PubMed
    NEDD8 complexes with PubMed
    pro-FMRFamide-related neuropeptide FF isoform 1 preproprotein NPFF upregulates PubMed
    nuclear receptor subfamily 4 group A member 2 NR4A2 upregulates PubMed
    5'-nucleotidase isoform 1 preproprotein NT5E upregulates PubMed
    P2Y purinoceptor 14 P2RY14 downregulates PubMed
    partitioning defective 6 homolog gamma PARD6G modulates PubMed
    poly(rC)-binding protein 3 isoform 1 PCBP3 downregulates PubMed
    high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform a PDE9A downregulates PubMed
    p53 apoptosis effector related to PMP-22 PERP upregulates PubMed
    phosphatase and actin regulator 2 isoform 3 PHACTR2 downregulates PubMed
    phosphatidylinositol-glycan biosynthesis class F protein isoform 1 PIGF downregulates PubMed
    peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 PIN1 interacts with PubMed
    zinc finger protein PLAGL1 isoform 2 PLAGL1 downregulates PubMed
    urokinase-type plasminogen activator isoform 1 preproprotein PLAU upregulates PubMed
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform a PLCB1 downregulates PubMed
    PI-PLC X domain-containing protein 2 isoform b PLCXD2 upregulates PubMed
    plectin isoform 1c PLEC relocalizes PubMed
    polyamine-modulated factor 1-binding protein 1 isoform a PMFBP1 downregulates PubMed
    peroxisome proliferator-activated receptor gamma isoform 1 PPARG downregulates PubMed
    peptidyl-prolyl cis-trans isomerase A isoform 1 PPIA binds PubMed
    5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 1 PRKAA1 inhibited by PubMed
    5'-AMP-activated protein kinase catalytic subunit alpha-2 PRKAA2 inhibited by PubMed
    5'-AMP-activated protein kinase subunit beta-1 PRKAB1 inhibited by PubMed
    5'-AMP-activated protein kinase subunit beta-2 PRKAB2 inhibited by PubMed
    cAMP-dependent protein kinase catalytic subunit alpha isoform Calpha1 PRKACA inhibited by PubMed
    cAMP-dependent protein kinase catalytic subunit beta isoform 2 PRKACB inhibited by PubMed
    cAMP-dependent protein kinase catalytic subunit gamma PRKACG inhibited by PubMed
    5'-AMP-activated protein kinase subunit gamma-1 isoform 1 PRKAG1 inhibited by PubMed
    cAMP-dependent protein kinase type I-alpha regulatory subunit isoform a PRKAR1A inhibited by PubMed
    cAMP-dependent protein kinase type I-beta regulatory subunit PRKAR1B inhibited by PubMed
    cAMP-dependent protein kinase type II-alpha regulatory subunit isoform a PRKAR2A inhibited by PubMed
    cAMP-dependent protein kinase type II-beta regulatory subunit PRKAR2B inhibited by PubMed
    prolactin precursor PRL downregulates PubMed
    prokineticin-2 isoform b precursor PROK2 upregulates PubMed
    proteasome subunit alpha type-1 isoform 2 PSMA1 interacts with PubMed
    proteasome subunit alpha type-2 PSMA2 interacts with PubMed
    proteasome subunit alpha type-3 isoform 1 PSMA3 interacts with PubMed
    proteasome subunit alpha type-4 isoform 1 PSMA4 interacts with PubMed
    proteasome subunit alpha type-5 isoform 1 PSMA5 interacts with PubMed
    proteasome subunit alpha type-6 isoform a PSMA6 interacts with PubMed
    proteasome subunit alpha type-7 PSMA7 interacts with PubMed
    proteasome subunit beta type-1 PSMB1 interacts with PubMed
    proteasome subunit beta type-10 precursor PSMB10 interacts with PubMed
    proteasome subunit beta type-2 isoform 1 PSMB2 interacts with PubMed
    proteasome subunit beta type-3 PSMB3 interacts with PubMed
    proteasome subunit beta type-4 PSMB4 interacts with PubMed
    proteasome subunit beta type-5 isoform 1 PSMB5 interacts with PubMed
    proteasome subunit beta type-6 isoform 1 precursor PSMB6 interacts with PubMed
    proteasome subunit beta type-7 precursor PSMB7 interacts with PubMed
    proteasome subunit beta type-8 isoform E1 precursor PSMB8 interacts with PubMed
    proteasome subunit beta type-9 precursor PSMB9 interacts with PubMed
    26S protease regulatory subunit 4 isoform a PSMC1 interacts with PubMed
    26S protease regulatory subunit 7 isoform 1 PSMC2 interacts with PubMed
    26S protease regulatory subunit 6A PSMC3 interacts with PubMed
    26S protease regulatory subunit 6B isoform 1 PSMC4 interacts with PubMed
    26S protease regulatory subunit 8 isoform 1 PSMC5 interacts with PubMed
    26S protease regulatory subunit 10B PSMC6 interacts with PubMed
    26S proteasome non-ATPase regulatory subunit 1 isoform 1 PSMD1 interacts with PubMed
    26S proteasome non-ATPase regulatory subunit 10 isoform 1 PSMD10 interacts with PubMed
    26S proteasome non-ATPase regulatory subunit 11 PSMD11 interacts with PubMed
    26S proteasome non-ATPase regulatory subunit 12 isoform 1 PSMD12 interacts with PubMed
    26S proteasome non-ATPase regulatory subunit 13 isoform 1 PSMD13 interacts with PubMed
    26S proteasome non-ATPase regulatory subunit 2 isoform 1 PSMD2 interacts with PubMed
    26S proteasome non-ATPase regulatory subunit 3 PSMD3 interacts with PubMed
    26S proteasome non-ATPase regulatory subunit 4 isoform 2 PSMD4 interacts with PubMed
    26S proteasome non-ATPase regulatory subunit 5 isoform 1 PSMD5 interacts with PubMed
    26S proteasome non-ATPase regulatory subunit 6 isoform 2 PSMD6 interacts with PubMed
    26S proteasome non-ATPase regulatory subunit 7 PSMD7 interacts with PubMed
    26S proteasome non-ATPase regulatory subunit 8 PSMD8 interacts with PubMed
    26S proteasome non-ATPase regulatory subunit 9 isoform 1 PSMD9 interacts with PubMed
    proteasome activator complex subunit 1 isoform 1 PSME1 interacts with PubMed
    proteasome activator complex subunit 2 PSME2 interacts with PubMed
    proteasome activator complex subunit 3 isoform 1 PSME3 interacts with PubMed
    PSME3 interacts with PubMed
    proteasome activator complex subunit 4 PSME4 interacts with PubMed
    proteasome inhibitor PI31 subunit isoform 1 PSMF1 interacts with PubMed
    purine-rich element-binding protein gamma isoform A PURG modulates PubMed
    ras-related protein Rab-7a RAB7A regulated by PubMed
    V(D)J recombination-activating protein 2 RAG2 downregulates PubMed
    RNA-binding protein 34 isoform 1 RBM34 downregulates PubMed
    E3 ubiquitin-protein ligase RBX1 RBX1 complexes with PubMed
    RBX1 interacts with PubMed
    RBX1 interacts with PubMed
    RBX1 complexes with PubMed
    rho-related GTP-binding protein RhoU RHOU downregulates PubMed
    rho-related GTP-binding protein RhoE precursor RND3 modulates PubMed
    E3 ubiquitin-protein ligase RNF216 isoform a RNF216 binds PubMed
    RNF216 interacts with PubMed
    RNF216 binds PubMed
    RNF216 binds PubMed
    RING-box protein 2 isoform 1 RNF7 interacts with PubMed
    RNF7 complexes with PubMed
    RNF7 interacts with PubMed
    RNF7 complexes with PubMed
    RNF7 interacts with PubMed
    nuclear receptor ROR-beta RORB upregulates PubMed
    replication protein A 32 kDa subunit isoform 1 RPA2 inhibited by PubMed
    radical S-adenosyl methionine domain-containing protein 2 RSAD2 downregulates PubMed
    runt-related transcription factor 1 isoform AML1c RUNX1 regulates PubMed
    RUNX1 inhibits PubMed
    RUNX1 interacts with PubMed
    RUNX1 interacts with PubMed
    runt-related transcription factor 2 isoform b RUNX2 inhibits PubMed
    runt-related transcription factor 3 isoform 2 RUNX3 inhibits PubMed
    sphingosine 1-phosphate receptor 1 S1PR1 downregulates PubMed
    diamine acetyltransferase 1 SAT1 modulates PubMed
    SAT1 binds PubMed
    sodium channel protein type 3 subunit alpha isoform 1 SCN3A downregulates PubMed
    monocarboxylate transporter 7 SLC16A6 downregulates PubMed
    solute carrier family 22 member 1 isoform a SLC22A1 upregulates PubMed
    mitochondrial 2-oxodicarboxylate carrier isoform 1 SLC25A21 downregulates PubMed
    sodium- and chloride-dependent transporter XTRP3 isoform 1 SLC6A20 downregulates PubMed
    slit homolog 2 protein isoform 1 precursor SLIT2 upregulates PubMed
    mothers against decapentaplegic homolog 1 SMAD1 upregulates PubMed
    SPARC-related modular calcium-binding protein 1 isoform 2 precursor SMOC1 upregulates PubMed
    superoxide dismutase SOD2 upregulates PubMed
    nuclear body protein SP140 isoform 1 SP140 binds PubMed
    SP140 interacts with PubMed
    SP140 binds PubMed
    spondin-1 precursor SPON1 downregulates PubMed
    protein sprouty homolog 1 SPRY1 upregulates PubMed
    SPRY domain-containing SOCS box protein 1 SPSB1 downregulates PubMed
    sequestosome-1 isoform 1 SQSTM1 interacts with PubMed
    serine/arginine-rich splicing factor 4 SRSF4 regulated by PubMed
    statherin isoform a precursor STATH upregulates PubMed
    E3 ubiquitin-protein ligase CHIP isoform a STUB1 interacts with PubMed
    taste receptor type 2 member 40 TAS2R40 downregulates PubMed
    serine/threonine-protein kinase TBK1 TBK1 interacts with PubMed
    F-box-like/WD repeat-containing protein TBL1XR1 isoform 1 TBL1XR1 interacts with PubMed
    T-box transcription factor TBX21 TBX21 downregulates PubMed
    transducin-like enhancer protein 1 isoform 2 TLE1 upregulates PubMed
    toll-like receptor 5 precursor TLR5 downregulates PubMed
    transmembrane and TPR repeat-containing protein 2 isoform 1 precursor TMTC2 upregulates PubMed
    tumor necrosis factor receptor superfamily member 10D precursor TNFRSF10D upregulates PubMed
    tumor necrosis factor receptor superfamily member 14 isoform 1 precursor TNFRSF14 downregulates PubMed
    tumor necrosis factor receptor superfamily member 8 isoform 1 precursor TNFRSF8 upregulates PubMed
    tumor necrosis factor ligand superfamily member 10 isoform 1 TNFSF10 downregulates PubMed
    tumor necrosis factor ligand superfamily member 15 isoform VEGI-251 precursor TNFSF15 upregulates PubMed
    tumor necrosis factor ligand superfamily member 8 isoform 1 TNFSF8 upregulates PubMed
    cellular tumor antigen p53 isoform a TP53 stabilizes PubMed
    TP53 binds PubMed
    thiamin pyrophosphokinase 1 isoform a TPK1 upregulates PubMed
    TNF receptor-associated factor 1 isoform a TRAF1 upregulates PubMed
    TRAF3-interacting JNK-activating modulator isoform 1 TRAF3IP3 downregulates PubMed
    thyrotropin-releasing hormone receptor TRHR downregulates PubMed
    E3 ubiquitin-protein ligase TRIM36 isoform 1 TRIM36 downregulates PubMed
    tetratricopeptide repeat protein 28 TTC28 downregulates PubMed
    tetratricopeptide repeat protein 30A TTC30A downregulates PubMed
    beta-taxilin TXLNB downregulates PubMed
    uveal autoantigen with coiled-coil domains and ankyrin repeats isoform 1 UACA downregulates PubMed
    polyubiquitin-B precursor UBB inhibited by PubMed
    polyubiquitin-C UBC inhibited by PubMed
    ubiquitin-conjugating enzyme E2 D2 isoform 1 UBE2D2 cooperates with PubMed
    NEDD8-conjugating enzyme UBE2F isoform 1 UBE2F interacts with PubMed
    UBE2F interacts with PubMed
    UBE2F interacts with PubMed
    ubiquitin-like protein 4A UBL4A interacts with PubMed
    E3 ubiquitin-protein ligase UBR2 isoform 1 UBR2 interacts with PubMed
    mitochondrial uncoupling protein 3 isoform UCP3L UCP3 downregulates PubMed
    NKG2D ligand 1 isoform 1 precursor ULBP1 downregulates PubMed
    ULBP1 inhibits PubMed
    ULBP1 inhibits PubMed
    NKG2D ligand 2 preproprotein ULBP2 inhibits PubMed
    ULBP2 downregulates PubMed
    ULBP2 inhibits PubMed
    NKG2D ligand 3 ULBP3 downregulates PubMed
    ULBP3 inhibits PubMed
    ULBP3 inhibits PubMed
    vimentin VIM co-localizes with PubMed
    XIAP-associated factor 1 isoform 1 XAF1 downregulates PubMed
    xin actin-binding repeat-containing protein 1 isoform 1 XIRP1 upregulates PubMed
    X-ray repair cross-complementing protein 6 isoform 1 XRCC6 binds PubMed
    xylosyltransferase 1 precursor XYLT1 modulates PubMed
    zinc finger and BTB domain-containing protein 16 ZBTB16 downregulates PubMed
    zinc finger protein 774 ZNF774 upregulates PubMed

    Go to the HIV-1, Human Interaction Database

    • 2-LTR circle formation, organism-specific biosystem (from REACTOME)
      2-LTR circle formation, organism-specific biosystemThe formation of 2-LTR circles requires the action of the cellular non-homologous DNA end-joining pathway. Specifically the cellular Ku, XRCC4 and ligase IV proteins are needed. Evidence for this i...
    • APOBEC3G mediated resistance to HIV-1 infection, organism-specific biosystem (from REACTOME)
      APOBEC3G mediated resistance to HIV-1 infection, organism-specific biosystemRepresentatives of the apolipoprotein B mRNA editing enzyme catalytic polypeptide 3 (APOBEC3) family provide innate resistance to exogeneous and endogenous retroviruses (see Cullen 2006 for a recent ...
    • Assembly Of The HIV Virion, organism-specific biosystem (from REACTOME)
      Assembly Of The HIV Virion, organism-specific biosystemVirion assembly packages all the components required for infectivity. These steps include two copies of the positive sense genomic viral RNA, cellular tRNALys, the viral envelope (Env) protein, the G...
    • Autointegration results in viral DNA circles, organism-specific biosystem (from REACTOME)
      Autointegration results in viral DNA circles, organism-specific biosystemIn this pathway, the viral integration machinery uses a site within the viral DNA as an integration target. This results in a covalent rearrangment of the viral DNA. The resulting DNA forms are no...
    • Binding and entry of HIV virion, organism-specific biosystem (from REACTOME)
      Binding and entry of HIV virion, organism-specific biosystemHIV enters cells by fusion at the cell surface, that results in a productive infection. The envelope (Env) protein of HIV mediates entry. Env is composed of a surface subunit, gp120, and a transmemb...
    • Budding and maturation of HIV virion, organism-specific biosystem (from REACTOME)
      Budding and maturation of HIV virion, organism-specific biosystemWith the virus components precariously assembled on the inner leaflet of the plasma membrane, the host cell machinery is required for viral budding. The virus takes advantage of the host ESCRT pathwa...
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Early Phase of HIV Life Cycle, organism-specific biosystem (from REACTOME)
      Early Phase of HIV Life Cycle, organism-specific biosystemIn the early phase of HIV lifecycle, an active virion binds and enters a target cell mainly by specific interactions of the viral envelope proteins with host cell surface receptors. The virion core...
    • HIV Infection, organism-specific biosystem (from REACTOME)
      HIV Infection, organism-specific biosystemThe global pandemic of Human Immunodeficiency Virus (HIV) infection has resulted in tens of millions of people infected by the virus and millions more affected. UNAIDS estimates around 40 million ...
    • HIV Life Cycle, organism-specific biosystem (from REACTOME)
      HIV Life Cycle, organism-specific biosystemThe life cycle of HIV-1 is divided into early and late phases, shown schematically in the figure. In the early phase, an HIV-1 virion binds to receptors and co-receptors on the human host cell surfac...
    • Host Interactions of HIV factors, organism-specific biosystem (from REACTOME)
      Host Interactions of HIV factors, organism-specific biosystemLike all viruses, HIV-1 must co-opt the host cell macromolecular transport and processing machinery. HIV-1 Vpr and Rev proteins play key roles in this co-optation. Efficient HIV-1 replication likewis...
    • Infectious disease, organism-specific biosystem (from REACTOME)
      Infectious disease, organism-specific biosystem
      Infectious disease
    • Integration of provirus, organism-specific biosystem (from REACTOME)
      Integration of provirus, organism-specific biosystemFor retroviral DNA to direct production of progeny virions it must become covalently integrated into the host cell chromosome (reviewed in Coffin et al. 1997; Hansen et al. 1998). Analyses of mutants...
    • Integration of viral DNA into host genomic DNA, organism-specific biosystem (from REACTOME)
      Integration of viral DNA into host genomic DNA, organism-specific biosystemFollowing nuclear entry, the viral preintegration complex (PIC) must select a site for integration in a host cell chromosome, and then carry out the chemical steps of the reaction. At the chromosomal...
    • Interactions of Vpr with host cellular proteins, organism-specific biosystem (from REACTOME)
      Interactions of Vpr with host cellular proteins, organism-specific biosystemVpr has been implicated in multiple processes during HIV-1 replication, including nuclear import of the pre-integration complex (PIC)(Heinzinger et al., 1994), apoptosis (Stewart et al., 1997) and in...
    • Late Phase of HIV Life Cycle, organism-specific biosystem (from REACTOME)
      Late Phase of HIV Life Cycle, organism-specific biosystemThe late phase of the HIV-1 life cycle includes the regulated expression of the HIV gene products and the assembly of viral particles. The assembly of viral particles will be covered in a later relea...
    • Minus-strand DNA synthesis, organism-specific biosystem (from REACTOME)
      Minus-strand DNA synthesis, organism-specific biosystemIn the first part of reverse transcription, minus-strand synthesis, a DNA strand complementary to the HIV genomic RNA is synthesized, using the viral RNA as a template and a host cell lysine tRNA mol...
    • Plus-strand DNA synthesis, organism-specific biosystem (from REACTOME)
      Plus-strand DNA synthesis, organism-specific biosystemTwo specific polypurine tracts (PPT sequences) in the viral RNA, one within the pol gene (central or cPPT) and one immediately preceding the U3 sequence (3' PPT), are spared from degradation during m...
    • Reverse Transcription of HIV RNA, organism-specific biosystem (from REACTOME)
      Reverse Transcription of HIV RNA, organism-specific biosystemThe RNA genome of HIV-1, like that of other retroviruses, is reverse-transcribed (Baltimore 1970; Temin and Mizutani 1970) into double-stranded DNA, which is then integrated into a host cell chromoso...
    • Uncoating of the HIV Virion, organism-specific biosystem (from REACTOME)
      Uncoating of the HIV Virion, organism-specific biosystemHIV-1 uncoating is a poorly understood process. It likely involves a progressive and partial dissembly of matrix and capsid layers. While viral proteins like MA and Nef are thought to be involved, t...
    • Vif-mediated degradation of APOBEC3G, organism-specific biosystem (from REACTOME)
      Vif-mediated degradation of APOBEC3G, organism-specific biosystemThe HIV-1 accessory protein Vif (Viral infectivity factor) is required for the efficient infection of primary cell populations (e.g., lymphocytes and macrophages) and 'non-permissive' cell lines. Vif...
    • Vpr-mediated nuclear import of PICs, organism-specific biosystem (from REACTOME)
      Vpr-mediated nuclear import of PICs, organism-specific biosystemVpr appears to function in anchoring the PIC to the nuclear envelope. This anchoring likely involves interactions between Vpr and host nucleoporins.
    Products Interactant Other Gene Complex Source Pubs Description

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001802.1 Reference assembly

      Range
      4587..5165
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_057851.1 Vif [Human immunodeficiency virus 1]

      See identical proteins and their annotated locations for NP_057851.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P69720, P69721, P69722, P69723
      UniProtKB/TrEMBL
      Q77YG0
      Conserved Domains (1) summary
      pfam00559
      Location:1192
      Vif; Retroviral Vif (Viral infectivity) protein
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