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    Hdac7 histone deacetylase 7 [ Mus musculus (house mouse) ]

    Gene ID: 56233, updated on 13-Aug-2017
    Official Symbol
    Hdac7provided by MGI
    Official Full Name
    histone deacetylase 7provided by MGI
    Primary source
    MGI:MGI:1891835
    See related
    Ensembl:ENSMUSG00000022475 Vega:OTTMUSG00000029597
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HD7; HD7a; Hdac7a; mFLJ00062; 5830434K02Rik
    Orthologs
    Location:
    15; 15 F1
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (97792664..97844502, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (97623112..97662102, complement)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene Rap guanine nucleotide exchange factor (GEF) 3 Neighboring gene uncharacterized LOC102636367 Neighboring gene predicted gene, 46535 Neighboring gene solute carrier family 48 (heme transporter), member 1 Neighboring gene predicted gene, 33636 Neighboring gene predicted gene, 33690 Neighboring gene vitamin D (1,25-dihydroxyvitamin D3) receptor Neighboring gene transmembrane protein 106C

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    14-3-3 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    NAD-dependent histone deacetylase activity (H3-K14 specific) IEA
    Inferred from Electronic Annotation
    more info
     
    activating transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone deacetylase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase C binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    repressing transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    B cell activation TAS
    Traceable Author Statement
    more info
    PubMed 
    B cell differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    cell-cell junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chromatin organization TAS
    Traceable Author Statement
    more info
    PubMed 
    covalent chromatin modification IEA
    Inferred from Electronic Annotation
    more info
     
    histone deacetylation IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of NIK/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of interleukin-2 production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of striated muscle tissue development TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription, DNA-templated TAS
    Traceable Author Statement
    more info
    PubMed 
    nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of cell migration involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    vasculogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    histone deacetylase complex TAS
    Traceable Author Statement
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    Preferred Names
    histone deacetylase 7
    Names
    histone deacetylase 7A
    NP_001191204.1
    NP_001191205.1
    NP_001191206.1
    NP_001191207.1
    NP_001191208.1
    NP_001191209.1
    NP_001191210.1
    NP_062518.2
    XP_006521266.1
    XP_006521268.1
    XP_006521270.1
    XP_006521271.1
    XP_006521272.1
    XP_006521273.1
    XP_011244001.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001204275.1NP_001191204.1  histone deacetylase 7 isoform 1

      See identical proteins and their annotated locations for NP_001191204.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC158787
      Consensus CDS
      CCDS57006.1
      UniProtKB/Swiss-Prot
      Q8C2B3
      Related
      ENSMUSP00000112110.2, OTTMUSP00000037987, ENSMUST00000116409.8, OTTMUST00000073417
      Conserved Domains (1) summary
      cd10008
      Location:522897
      HDAC7; Histone deacetylase 7
    2. NM_001204276.1NP_001191205.1  histone deacetylase 7 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC158787
      Consensus CDS
      CCDS57005.1
      UniProtKB/Swiss-Prot
      Q8C2B3
      Related
      ENSMUSP00000113380.1, OTTMUSP00000038007, ENSMUST00000118294.7, OTTMUST00000073445
      Conserved Domains (1) summary
      cd10008
      Location:515890
      HDAC7; Histone deacetylase 7
    3. NM_001204277.1NP_001191206.1  histone deacetylase 7 isoform 3

      See identical proteins and their annotated locations for NP_001191206.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and has multiple differences in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK044287, BB648696
      Consensus CDS
      CCDS57007.1
      UniProtKB/Swiss-Prot
      Q8C2B3
      Related
      ENSMUSP00000078766.7, OTTMUSP00000038006, ENSMUST00000079838.13, OTTMUST00000073444
      Conserved Domains (1) summary
      cd10008
      Location:513888
      HDAC7; Histone deacetylase 7
    4. NM_001204278.1NP_001191207.1  histone deacetylase 7 isoform 5

      See identical proteins and their annotated locations for NP_001191207.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an exon in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
      Source sequence(s)
      AC158787
      Consensus CDS
      CCDS57004.1
      UniProtKB/Swiss-Prot
      Q8C2B3
      Related
      ENSMUSP00000112109.2, OTTMUSP00000037986, ENSMUST00000116408.8, OTTMUST00000073416
      Conserved Domains (1) summary
      cd10008
      Location:485860
      HDAC7; Histone deacetylase 7
    5. NM_001204279.1NP_001191208.1  histone deacetylase 7 isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks a coding exon and uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (6) is shorter than isoform 1.
      Source sequence(s)
      AC158787
      Consensus CDS
      CCDS57001.1
      UniProtKB/TrEMBL
      E9PXW1
      Related
      ENSMUSP00000112459.1, OTTMUSP00000037988, ENSMUST00000119670.7, OTTMUST00000073418
      Conserved Domains (1) summary
      cd10008
      Location:461836
      HDAC7; Histone deacetylase 7
    6. NM_001204280.1NP_001191209.1  histone deacetylase 7 isoform 7

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks three exons in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (7) is shorter than isoform 1.
      Source sequence(s)
      AC158787
      Consensus CDS
      CCDS57003.1
      UniProtKB/TrEMBL
      E9PXW8
      Related
      ENSMUSP00000112446.1, OTTMUSP00000037989, ENSMUST00000120683.7, OTTMUST00000073419
      Conserved Domains (1) summary
      cl17011
      Location:485812
      Arginase_HDAC; Arginase-like and histone-like hydrolases
    7. NM_001204281.1NP_001191210.1  histone deacetylase 7 isoform 8

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR and lacks two exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (8) is shorter than isoform 1.
      Source sequence(s)
      AC158787
      Consensus CDS
      CCDS57002.1
      UniProtKB/TrEMBL
      E9PX62
      Related
      ENSMUSP00000112641.1, OTTMUSP00000038008, ENSMUST00000121514.7, OTTMUST00000073446
      Conserved Domains (1) summary
      cd10008
      Location:420795
      HDAC7; Histone deacetylase 7
    8. NM_019572.3NP_062518.2  histone deacetylase 7 isoform 4

      See identical proteins and their annotated locations for NP_062518.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and has multiple differences in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK044287, BB648696, BC057332
      Consensus CDS
      CCDS37188.1
      UniProtKB/Swiss-Prot
      Q8C2B3
      Related
      ENSMUSP00000085744.5, OTTMUSP00000037990, ENSMUST00000088402.11, OTTMUST00000073420
      Conserved Domains (1) summary
      cd10008
      Location:507882
      HDAC7; Histone deacetylase 7

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

      Range
      97792664..97844502 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521203.2XP_006521266.1  histone deacetylase 7 isoform X2

      Conserved Domains (1) summary
      cd10008
      Location:544919
      HDAC7; Histone deacetylase 7
    2. XM_006521210.2XP_006521273.1  histone deacetylase 7 isoform X3

      See identical proteins and their annotated locations for XP_006521273.1

      UniProtKB/Swiss-Prot
      Q8C2B3
      Conserved Domains (1) summary
      cd10008
      Location:522897
      HDAC7; Histone deacetylase 7
    3. XM_006521208.3XP_006521271.1  histone deacetylase 7 isoform X3

      See identical proteins and their annotated locations for XP_006521271.1

      UniProtKB/Swiss-Prot
      Q8C2B3
      Conserved Domains (1) summary
      cd10008
      Location:522897
      HDAC7; Histone deacetylase 7
    4. XM_006521205.2XP_006521268.1  histone deacetylase 7 isoform X3

      See identical proteins and their annotated locations for XP_006521268.1

      UniProtKB/Swiss-Prot
      Q8C2B3
      Conserved Domains (1) summary
      cd10008
      Location:522897
      HDAC7; Histone deacetylase 7
    5. XM_006521209.2XP_006521272.1  histone deacetylase 7 isoform X3

      See identical proteins and their annotated locations for XP_006521272.1

      UniProtKB/Swiss-Prot
      Q8C2B3
      Conserved Domains (1) summary
      cd10008
      Location:522897
      HDAC7; Histone deacetylase 7
    6. XM_006521207.3XP_006521270.1  histone deacetylase 7 isoform X3

      See identical proteins and their annotated locations for XP_006521270.1

      UniProtKB/Swiss-Prot
      Q8C2B3
      Conserved Domains (1) summary
      cd10008
      Location:522897
      HDAC7; Histone deacetylase 7
    7. XM_011245699.1XP_011244001.1  histone deacetylase 7 isoform X1

      Conserved Domains (1) summary
      cd10008
      Location:478853
      HDAC7; Histone deacetylase 7

    RNA

    1. XR_875306.1 RNA Sequence

    2. XR_875307.2 RNA Sequence

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