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    Trpa1 transient receptor potential cation channel, subfamily A, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 277328, updated on 1-Aug-2017
    Official Symbol
    Trpa1provided by MGI
    Official Full Name
    transient receptor potential cation channel, subfamily A, member 1provided by MGI
    Primary source
    MGI:MGI:3522699
    See related
    Ensembl:ENSMUSG00000032769 Vega:OTTMUSG00000049207
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Anktm1; TRPA1b
    Orthologs
    Location:
    1; 1 A3
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (14872648..14919014, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (14862729..14908943, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein L5, pseudogene 1 Neighboring gene predicted gene, 33500 Neighboring gene predicted gene 5048 Neighboring gene predicted gene, 19917

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    calcium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    calcium-release channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ion channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ion channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    osmolarity-sensing cation channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    temperature-gated cation channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    voltage-gated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    calcium ion transmembrane import into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cation transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to carbon dioxide ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to cold ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to heat ISO
    Inferred from Sequence Orthology
    more info
     
    detection of chemical stimulus involved in sensory perception of pain IDA
    Inferred from Direct Assay
    more info
    PubMed 
    detection of chemical stimulus involved in sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    detection of mechanical stimulus involved in sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of anion transport ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    protein homotetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of blood circulation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of neuronal action potential ISO
    Inferred from Sequence Orthology
    more info
     
    response to cold IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to cold IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to drug IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to hydrogen peroxide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to organic cyclic compound IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to organic substance ISO
    Inferred from Sequence Orthology
    more info
     
    response to pain IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    thermoception IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    transport IEA
    Inferred from Electronic Annotation
    more info
     
    urinary bladder smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    stereocilium bundle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    transient receptor potential cation channel subfamily A member 1
    Names
    ankyrin-like with transmembrane domains protein 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001348288.1NP_001335217.1  transient receptor potential cation channel subfamily A member 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.
      Source sequence(s)
      AC121789, AK045771, KF460461
      UniProtKB/Swiss-Prot
      Q8BLA8
      UniProtKB/TrEMBL
      V5TCP9
    2. NM_177781.5NP_808449.1  transient receptor potential cation channel subfamily A member 1 isoform 1

      See identical proteins and their annotated locations for NP_808449.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC121789, AK045771
      Consensus CDS
      CCDS35516.1
      UniProtKB/Swiss-Prot
      Q8BLA8
      Related
      ENSMUSP00000043594.4, OTTMUSP00000068034, ENSMUST00000041447.4, OTTMUST00000125545
      Conserved Domains (4) summary
      cd00204
      Location:93219
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00520
      Location:800975
      Ion_trans; Ion transport protein
      pfam12796
      Location:487578
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:98129
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      14872648..14919014 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006495526.2XP_006495589.1  transient receptor potential cation channel subfamily A member 1 isoform X1

      See identical proteins and their annotated locations for XP_006495589.1

      UniProtKB/TrEMBL
      V5TCP9
      Conserved Domains (4) summary
      cd00204
      Location:93219
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00520
      Location:770945
      Ion_trans; Ion transport protein
      pfam12796
      Location:487578
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:98129
      ANK; ANK repeat [structural motif]
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