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    Fcer2a Fc receptor, IgE, low affinity II, alpha polypeptide [ Mus musculus (house mouse) ]

    Gene ID: 14128, updated on 25-May-2017
    Official Symbol
    Fcer2aprovided by MGI
    Official Full Name
    Fc receptor, IgE, low affinity II, alpha polypeptideprovided by MGI
    Primary source
    MGI:MGI:95497
    See related
    Ensembl:ENSMUSG00000005540 Vega:OTTMUSG00000059173
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CD23; Fce2; Fcer2; Ly-42
    Orthologs
    Location:
    8 A1.1; 8 1.92 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (3680144..3694174, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (3681737..3694174, complement)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 39121 Neighboring gene predicted gene 45231 Neighboring gene Foxo1 corepressor Neighboring gene trafficking protein particle complex 5 Neighboring gene C-type lectin domain family 4, member g Neighboring gene predicted gene 16553 Neighboring gene CD209a antigen

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
      Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Epstein-Barr virus infection, conserved biosystem (from KEGG)
      Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
      Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Hematopoietic cell lineage, conserved biosystem (from KEGG)
      Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • IL-3 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-3 Signaling Pathway, organism-specific biosystemInterleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common b...

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    IgE binding IEA
    Inferred from Electronic Annotation
    more info
     
    carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    low affinity immunoglobulin epsilon Fc receptor
    Names
    FC epsilon RII
    fc-epsilon-RII
    low-affinity IgE receptor
    lymphocyte IgE receptor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001253737.1NP_001240666.1  low affinity immunoglobulin epsilon Fc receptor isoform B

      See identical proteins and their annotated locations for NP_001240666.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has a different 5' end with an alternate start codon, compared to variant 1. The resulting protein (isoform B) has a shorter and distinct N-terminus when it is compared to isoform A. Although variants 2 and 3 encode a protein of the same length (330 aa), the sequence of the two proteins (isoform B and isoform C) are different.
      Source sequence(s)
      AC087183, M34163
      Consensus CDS
      CCDS85494.1
      UniProtKB/Swiss-Prot
      P20693
      Related
      ENSMUSP00000146568.1, OTTMUSP00000075648, ENSMUST00000208492.1, OTTMUST00000145175
      Conserved Domains (2) summary
      cd03590
      Location:185305
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      cl23720
      Location:72169
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    2. NM_001253739.1NP_001240668.1  low affinity immunoglobulin epsilon Fc receptor isoform C

      See identical proteins and their annotated locations for NP_001240668.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has a different 5' end with an alternate start codon, compared to variant 1. The resulting protein (isoform C) has a shorter and distinct N-terminus when it is compared to isoform A. Although variants 2 and 3 encode a protein of the same length (330 aa), the sequence of the two proteins (isoform B and isoform C) are different.
      Source sequence(s)
      AC087183, M34163
      Consensus CDS
      CCDS85491.1
      UniProtKB/Swiss-Prot
      P20693
      Related
      ENSMUSP00000146647.1, OTTMUSP00000075647, ENSMUST00000208145.1, OTTMUST00000145174
      Conserved Domains (2) summary
      cd03590
      Location:185305
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      cl23720
      Location:72169
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    3. NM_001253743.1NP_001240672.1  low affinity immunoglobulin epsilon Fc receptor isoform A precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses a different splice site in the 5' coding region, compared to variant 1. The resulting protein (isoform D) is shorter when it is compared to isoform A.
      Source sequence(s)
      AC087183, M34163
      UniProtKB/Swiss-Prot
      P20693
      Related
      ENSMUSP00000146689.1, OTTMUSP00000075651, ENSMUST00000207635.1, OTTMUST00000145178
      Conserved Domains (2) summary
      cd03590
      Location:159279
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      cl23720
      Location:46143
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    4. NM_001253745.1NP_001240674.1  low affinity immunoglobulin epsilon Fc receptor isoform E

      See identical proteins and their annotated locations for NP_001240674.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has a different 5' end with an alternate start codon and lacks an alternate exon in the coding region, compared to variant 1. The resulting protein (isoform E) has a shorter and distinct N-terminus when it is compared to isoform A. Although variants 5 and 6 encode a protein of the same length (309 aa), the sequence of the two proteins (isoform E and isoform F) are different. Isoform E has also been called Fc epsilon receptor II subtype b variant b delta 5.
      Source sequence(s)
      AC087183, M34163
      Consensus CDS
      CCDS85492.1
      UniProtKB/Swiss-Prot
      P20693
      UniProtKB/TrEMBL
      Q8VH33
      Related
      ENSMUSP00000146380.1, OTTMUSP00000075650, ENSMUST00000208603.1, OTTMUST00000145177
      Conserved Domains (2) summary
      cd03590
      Location:164284
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      cl23720
      Location:72148
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    5. NM_001253746.1NP_001240675.1  low affinity immunoglobulin epsilon Fc receptor isoform F

      See identical proteins and their annotated locations for NP_001240675.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) has a different 5' end with an alternate start codon and lacks an alternate exon in the coding region, compared to variant 1. The resulting protein (isoform F) has a shorter and distinct N-terminus when it is compared to isoform A. Although variants 5 and 6 encode a protein of the same length (309 aa), the sequence of the two proteins (isoform E and isoform F) are different. Isoform F has also been called Fc epsilon receptor II subtype b variant b delta 6.
      Source sequence(s)
      AC087183, M34163
      Consensus CDS
      CCDS85493.1
      UniProtKB/Swiss-Prot
      P20693
      UniProtKB/TrEMBL
      Q8VH32
      Related
      ENSMUSP00000146822.1, OTTMUSP00000075649, ENSMUST00000208438.1, OTTMUST00000145176
      Conserved Domains (2) summary
      cd03590
      Location:164284
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      cl23765
      Location:70127
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    6. NM_001253747.1NP_001240676.1  low affinity immunoglobulin epsilon Fc receptor isoform G

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks an alternate exon in the 5' coding region, compared to variant 1. The resulting protein (isoform G) is shorter when it is compared to isoform A.
      Source sequence(s)
      AC087183, M34163
      UniProtKB/Swiss-Prot
      P20693
      Related
      ENSMUSP00000147052.1, OTTMUSP00000075652, ENSMUST00000207463.1, OTTMUST00000145179
      Conserved Domains (2) summary
      cd03590
      Location:146266
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      cl23720
      Location:33130
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    7. NM_013517.4NP_038545.1  low affinity immunoglobulin epsilon Fc receptor isoform A

      See identical proteins and their annotated locations for NP_038545.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform A).
      Source sequence(s)
      AC087183, M34163
      Consensus CDS
      CCDS22071.1
      UniProtKB/Swiss-Prot
      P20693
      Related
      ENSMUSP00000005678.4, OTTMUSP00000075646, ENSMUST00000005678.5, OTTMUST00000145173
      Conserved Domains (2) summary
      cd03590
      Location:186306
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      cl23720
      Location:73170
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      3680144..3694174 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508697.3XP_006508760.1  low affinity immunoglobulin epsilon Fc receptor isoform X1

      Conserved Domains (2) summary
      cd03590
      Location:190310
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      cl23720
      Location:77174
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
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