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    PECAM1 platelet and endothelial cell adhesion molecule 1 [ Homo sapiens (human) ]

    Gene ID: 5175, updated on 8-May-2017
    Official Symbol
    PECAM1provided by HGNC
    Official Full Name
    platelet and endothelial cell adhesion molecule 1provided by HGNC
    Primary source
    HGNC:HGNC:8823
    See related
    Ensembl:ENSG00000261371 MIM:173445; Vega:OTTHUMG00000175829
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD31; PECA1; GPIIA'; PECAM-1; endoCAM; CD31/EndoCAM
    Summary
    The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. [provided by RefSeq, May 2010]
    Orthologs
    Location:
    17q23.3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 17 NC_000017.11 (64319415..64413844, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (62396775..62404856, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene testis expressed 2 Neighboring gene ribosomal protein L31 pseudogene 57 Neighboring gene microRNA 1273e Neighboring gene mast cell immunoglobulin like receptor 1

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat enhances vIL-6-induced angiogenesis and tumorigenesis of fibroblasts and human endothelial cells, which correlates with upregulation of CD31, CD34, SMA, VEGF, b-FGF, and cyclin D1 expression PubMed
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of platelet/endothelial cell adhesion molecule 1 (PECAM1, PECA1) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
      Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
      Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
      Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
    • Extracellular matrix organization, organism-specific biosystem (from REACTOME)
      Extracellular matrix organization, organism-specific biosystemThe extracellular matrix is a component of all mammalian tissues, a network consisting largely of the fibrous proteins collagen, elastin and associated-microfibrils, fibronectin and laminins embedded...
    • Fluid shear stress and atherosclerosis, organism-specific biosystem (from KEGG)
      Fluid shear stress and atherosclerosis, organism-specific biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
    • Fluid shear stress and atherosclerosis, conserved biosystem (from KEGG)
      Fluid shear stress and atherosclerosis, conserved biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Integrin cell surface interactions, organism-specific biosystem (from REACTOME)
      Integrin cell surface interactions, organism-specific biosystemThe extracellular matrix (ECM) is a network of macro-molecules that underlies all epithelia and endothelia and that surrounds all connective tissue cells. This matrix provides the mechanical strength...
    • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
      Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Leukocyte transendothelial migration, conserved biosystem (from KEGG)
      Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Malaria, organism-specific biosystem (from KEGG)
      Malaria, organism-specific biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
    • Malaria, conserved biosystem (from KEGG)
      Malaria, conserved biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
    • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
      Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
    • PECAM1 interactions, organism-specific biosystem (from REACTOME)
      PECAM1 interactions, organism-specific biosystemPECAM-1/CD31 is a member of the immunoglobulin superfamily (IgSF) and has been implicated to mediate the adhesion and trans-endothelial migration of T-lymphocytes into the vascular wall, T cell activ...
    • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
      Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...
    • Platelet degranulation, organism-specific biosystem (from REACTOME)
      Platelet degranulation, organism-specific biosystemPlatelets function as exocytotic cells, secreting a plethora of effector molecules at sites of vascular injury. Platelets contain a number of distinguishable storage granules including alpha granules...
    • Platelet homeostasis, organism-specific biosystem (from REACTOME)
      Platelet homeostasis, organism-specific biosystemUnder normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhesion and activation, suppresses coagulation, enhances fibrin cleavage and is anti-inflammatory in charact...
    • Platelet sensitization by LDL, organism-specific biosystem (from REACTOME)
      Platelet sensitization by LDL, organism-specific biosystemPhysiological concentrations (1g/L) of Low density lipoprotein (LDL) enhance platelet aggregation responses initiated by thrombin, collagen, and ADP. This enhancement involves the rapid phosphorylati...
    • Response to elevated platelet cytosolic Ca2+, organism-specific biosystem (from REACTOME)
      Response to elevated platelet cytosolic Ca2+, organism-specific biosystemActivation of phospholipase C enzymes results in the generation of second messengers of the phosphatidylinositol pathway. The events resulting from this pathway are a rise in intracellular calcium an...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ34100, FLJ58394

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cell recognition TAS
    Traceable Author Statement
    more info
    PubMed 
    diapedesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular matrix organization TAS
    Traceable Author Statement
    more info
     
    glomerular endothelium development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    leukocyte migration TAS
    Traceable Author Statement
    more info
     
    neutrophil degranulation TAS
    Traceable Author Statement
    more info
     
    phagocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    platelet degranulation TAS
    Traceable Author Statement
    more info
     
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane raft IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    platelet alpha granule membrane TAS
    Traceable Author Statement
    more info
     
    secretory granule membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    platelet endothelial cell adhesion molecule
    Names
    CD31 antigen
    platelet endothelial cell adhesion molecule-1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047009.1 RefSeqGene

      Range
      27924..99387
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000442.4NP_000433.4  platelet endothelial cell adhesion molecule precursor

      See identical proteins and their annotated locations for NP_000433.4

      Status: REVIEWED

      Source sequence(s)
      AC016489, AF281298, BC051822
      Consensus CDS
      CCDS74132.1
      UniProtKB/Swiss-Prot
      P16284
      UniProtKB/TrEMBL
      A0A075B738
      Related
      ENSP00000457421.1, OTTHUMP00000254150, ENST00000563924.5, OTTHUMT00000431142
      Conserved Domains (4) summary
      smart00410
      Location:43127
      IG_like; Immunoglobulin like
      pfam13895
      Location:328404
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:507576
      Ig_3; Immunoglobulin domain
      cl11960
      Location:43127
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p7 Primary Assembly

      Range
      64319415..64413844 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011524889.2XP_011523191.1  platelet endothelial cell adhesion molecule isoform X1

      See identical proteins and their annotated locations for XP_011523191.1

      UniProtKB/TrEMBL
      A0A075B738
      Conserved Domains (4) summary
      smart00410
      Location:43127
      IG_like; Immunoglobulin like
      pfam13895
      Location:328404
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:507576
      Ig_3; Immunoglobulin domain
      cl11960
      Location:43127
      Ig; Immunoglobulin domain
    2. XM_017024740.1XP_016880229.1  platelet endothelial cell adhesion molecule isoform X4

      Conserved Domains (4) summary
      smart00410
      Location:43127
      IG_like; Immunoglobulin like
      pfam13895
      Location:328404
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:507576
      Ig_3; Immunoglobulin domain
      cl11960
      Location:43127
      Ig; Immunoglobulin domain
    3. XM_011524890.1XP_011523192.1  platelet endothelial cell adhesion molecule isoform X1

      See identical proteins and their annotated locations for XP_011523192.1

      UniProtKB/TrEMBL
      A0A075B738
      Conserved Domains (4) summary
      smart00410
      Location:43127
      IG_like; Immunoglobulin like
      pfam13895
      Location:328404
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:507576
      Ig_3; Immunoglobulin domain
      cl11960
      Location:43127
      Ig; Immunoglobulin domain
    4. XM_017024738.1XP_016880227.1  platelet endothelial cell adhesion molecule isoform X1

      UniProtKB/TrEMBL
      A0A075B738
      Conserved Domains (4) summary
      smart00410
      Location:43127
      IG_like; Immunoglobulin like
      pfam13895
      Location:328404
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:507576
      Ig_3; Immunoglobulin domain
      cl11960
      Location:43127
      Ig; Immunoglobulin domain
    5. XM_017024741.1XP_016880230.1  platelet endothelial cell adhesion molecule isoform X7

    6. XM_017024739.1XP_016880228.1  platelet endothelial cell adhesion molecule isoform X3

    7. XM_005276882.1XP_005276939.1  platelet endothelial cell adhesion molecule isoform X5

      Conserved Domains (4) summary
      smart00410
      Location:43127
      IG_like; Immunoglobulin like
      pfam13895
      Location:328404
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:507576
      Ig_3; Immunoglobulin domain
      cl11960
      Location:43127
      Ig; Immunoglobulin domain
    8. XM_005276881.1XP_005276938.1  platelet endothelial cell adhesion molecule isoform X4

      Conserved Domains (4) summary
      smart00410
      Location:43127
      IG_like; Immunoglobulin like
      pfam13895
      Location:328404
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:507576
      Ig_3; Immunoglobulin domain
      cl11960
      Location:43127
      Ig; Immunoglobulin domain
    9. XM_005276880.1XP_005276937.1  platelet endothelial cell adhesion molecule isoform X2

      Conserved Domains (4) summary
      smart00410
      Location:43127
      IG_like; Immunoglobulin like
      pfam13895
      Location:328404
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:507576
      Ig_3; Immunoglobulin domain
      cl11960
      Location:43127
      Ig; Immunoglobulin domain
    10. XM_005276883.2XP_005276940.1  platelet endothelial cell adhesion molecule isoform X6

      Conserved Domains (4) summary
      smart00410
      Location:43127
      IG_like; Immunoglobulin like
      pfam13895
      Location:328404
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:507576
      Ig_3; Immunoglobulin domain
      cl11960
      Location:43127
      Ig; Immunoglobulin domain

    Alternate CHM1_1.1

    Genomic

    1. NC_018928.2 Alternate CHM1_1.1

      Range
      62461123..62469204 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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