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    Arhgap5 Rho GTPase activating protein 5 [ Mus musculus (house mouse) ]

    Gene ID: 11855, updated on 22-Apr-2017
    Official Symbol
    Arhgap5provided by MGI
    Official Full Name
    Rho GTPase activating protein 5provided by MGI
    Primary source
    MGI:MGI:1332637
    See related
    Ensembl:ENSMUSG00000035133
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p190B; p190-B
    Orthologs
    Location:
    12 C1; 12 22.16 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (52503771..52571978)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (53617064..53668839)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 35135 Neighboring gene predicted gene, 35188 Neighboring gene RIKEN cDNA 1700031P21 gene Neighboring gene predicted gene, 35239

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Focal Adhesion, organism-specific biosystem (from WikiPathways)
      Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
      Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Leukocyte transendothelial migration, conserved biosystem (from KEGG)
      Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
      Rho GTPase cycle, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
      Signaling by Rho GTPases, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    SH2 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    mammary gland development IMP
    Inferred from Mutant Phenotype
    more info
     
    positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of mesenchymal cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell size IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    rho GTPase-activating protein 5
    Names
    rho-type GTPase-activating protein 5

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009706.2NP_033836.2  rho GTPase-activating protein 5

      See identical proteins and their annotated locations for NP_033836.2

      Status: VALIDATED

      Source sequence(s)
      AK041016, BM940854, BU613221, CF742308, CO433888
      Consensus CDS
      CCDS36443.1
      UniProtKB/TrEMBL
      E9PYT0
      Related
      ENSMUSP00000106353.1, ENSMUST00000110725.1
      Conserved Domains (5) summary
      smart00441
      Location:428481
      FF; Contains two conserved F residues
      cd04373
      Location:12611445
      RhoGAP_p190; RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and ...
      pfam00071
      Location:28244
      Ras; Ras family
      pfam16512
      Location:260338
      RhoGAP-FF1; p190-A and -B Rho GAPs FF domain
      cl21455
      Location:31246
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      52503771..52571978
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243990.1XP_011242292.1  rho GTPase-activating protein 5 isoform X1

      See identical proteins and their annotated locations for XP_011242292.1

      UniProtKB/TrEMBL
      E9PYT0
      Conserved Domains (5) summary
      smart00441
      Location:428481
      FF; Contains two conserved F residues
      cd04373
      Location:12611445
      RhoGAP_p190; RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and ...
      pfam00071
      Location:28244
      Ras; Ras family
      pfam16512
      Location:260338
      RhoGAP-FF1; p190-A and -B Rho GAPs FF domain
      cl21455
      Location:31246
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    2. XM_006515438.3XP_006515501.1  rho GTPase-activating protein 5 isoform X1

      See identical proteins and their annotated locations for XP_006515501.1

      UniProtKB/TrEMBL
      E9PYT0
      Related
      ENSMUSP00000151809.1, ENSMUST00000219443.1
      Conserved Domains (5) summary
      smart00441
      Location:428481
      FF; Contains two conserved F residues
      cd04373
      Location:12611445
      RhoGAP_p190; RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and ...
      pfam00071
      Location:28244
      Ras; Ras family
      pfam16512
      Location:260338
      RhoGAP-FF1; p190-A and -B Rho GAPs FF domain
      cl21455
      Location:31246
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    3. XM_011243989.1XP_011242291.1  rho GTPase-activating protein 5 isoform X1

      See identical proteins and their annotated locations for XP_011242291.1

      UniProtKB/TrEMBL
      E9PYT0
      Conserved Domains (5) summary
      smart00441
      Location:428481
      FF; Contains two conserved F residues
      cd04373
      Location:12611445
      RhoGAP_p190; RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and ...
      pfam00071
      Location:28244
      Ras; Ras family
      pfam16512
      Location:260338
      RhoGAP-FF1; p190-A and -B Rho GAPs FF domain
      cl21455
      Location:31246
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    4. XM_006515439.2XP_006515502.1  rho GTPase-activating protein 5 isoform X2

      Conserved Domains (5) summary
      smart00441
      Location:428481
      FF; Contains two conserved F residues
      cd04373
      Location:12601444
      RhoGAP_p190; RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and ...
      pfam00071
      Location:28244
      Ras; Ras family
      pfam16512
      Location:260338
      RhoGAP-FF1; p190-A and -B Rho GAPs FF domain
      cl21455
      Location:31246
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
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