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    SMC3 cohesin subunit SMC3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853371, updated on 25-Nov-2017
    Gene symbol
    SMC3
    Gene description
    cohesin subunit SMC3
    Primary source
    SGD:S000003610
    Locus tag
    YJL074C
    Gene type
    protein coding
    RNA name
    cohesin subunit SMC3
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (299157..302849, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene Ics3p Neighboring gene Net1p Neighboring gene Jem1p Neighboring gene DNA replication protein PSF2

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Cell cycle - yeast, organism-specific biosystem (from KEGG)
      Cell cycle - yeast, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps (G1 and G2 phases). G1, S, and G...
    • Cell cycle - yeast, conserved biosystem (from KEGG)
      Cell cycle - yeast, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps (G1 and G2 phases). G1, S, and G...
    • Meiosis - yeast, organism-specific biosystem (from KEGG)
      Meiosis - yeast, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, one pair of sister chromatids recombines with, th...
    • Meiosis - yeast, conserved biosystem (from KEGG)
      Meiosis - yeast, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, one pair of sister chromatids recombines with, th...
    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to ATPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    ascospore formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome organization IEA
    Inferred from Electronic Annotation
    more info
     
    meiotic sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic sister chromatid cohesion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    replication-born double-strand break repair via sister chromatid exchange IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    synaptonemal complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear mitotic cohesin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Names
    cohesin subunit SMC3
    NP_012461.1
    • Subunit of the multiprotein cohesin complex; required for sister chromatid cohesion in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      299157..302849 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181507.1NP_012461.1  TPA: cohesin subunit SMC3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012461.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P47037
      Conserved Domains (4) summary
      cd03272
      Location:3174
      ABC_SMC3_euk; ATP-binding cassette domain of eukaryotic SMC3 proteins
      smart00968
      Location:534650
      SMC_hinge; SMC proteins Flexible Hinge Domain
      COG1196
      Location:11221
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl21455
      Location:11141209
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
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