Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    Slc12a2 solute carrier family 12, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 20496, updated on 8-Aug-2017
    Official Symbol
    Slc12a2provided by MGI
    Official Full Name
    solute carrier family 12, member 2provided by MGI
    Primary source
    MGI:MGI:101924
    See related
    Ensembl:ENSMUSG00000024597
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nkcc1; mBSC2; sy-ns; 9330166H04Rik
    Orthologs
    Location:
    18 D3; 18 32.15 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 18 NC_000084.6 (57878512..57946821)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (58038332..58106475)

    Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 19519 Neighboring gene predicted gene, 35751 Neighboring gene fibrillin 2 Neighboring gene predicted gene, 41741 Neighboring gene predicted gene, 26507

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ammonium transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ammonium transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    cation:chloride symporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    sodium:potassium:chloride symporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    symporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    ammonium transport ISO
    Inferred from Sequence Orthology
    more info
     
    branching involved in mammary gland duct morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chloride transport ISO
    Inferred from Sequence Orthology
    more info
     
    detection of mechanical stimulus involved in sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hyperosmotic response ISO
    Inferred from Sequence Orthology
    more info
     
    ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    mammary duct terminal end bud growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell volume ISO
    Inferred from Sequence Orthology
    more info
     
    potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    transepithelial ammonium transport ISO
    Inferred from Sequence Orthology
    more info
     
    transepithelial chloride transport ISO
    Inferred from Sequence Orthology
    more info
     
    transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    solute carrier family 12 member 2
    Names
    basolateral Na-K-Cl symporter
    bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1
    sodium/potassium/chloride cotransporters
    sodium/potassium/chloride transporters

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009194.3NP_033220.2  solute carrier family 12 member 2

      Status: VALIDATED

      Source sequence(s)
      AC127678, CJ172807, CN711123, U13174
      Consensus CDS
      CCDS37826.1
      UniProtKB/Swiss-Prot
      P55012
      UniProtKB/TrEMBL
      E9QM38
      Related
      ENSMUSP00000111023.2, ENSMUST00000115366.2
      Conserved Domains (3) summary
      TIGR00930
      Location:2101206
      2a30; K-Cl cotransporter
      pfam03522
      Location:7951206
      SLC12; Solute carrier family 12
      pfam08403
      Location:196257
      AA_permease_N; Amino acid permease N-terminal

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000084.6 Reference GRCm38.p4 C57BL/6J

      Range
      57878512..57946821
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525732.2XP_006525795.1  solute carrier family 12 member 2 isoform X1

      Conserved Domains (3) summary
      TIGR00930
      Location:2101190
      2a30; K-Cl cotransporter
      pfam03522
      Location:7951190
      SLC12; Solute carrier family 12
      pfam08403
      Location:196257
      AA_permease_N; Amino acid permease N-terminal

    RNA

    1. XR_001782351.1 RNA Sequence

    2. XR_001782352.1 RNA Sequence

    Support Center