Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    Sf1 splicing factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 22668, updated on 12-Nov-2017
    Official Symbol
    Sf1provided by MGI
    Official Full Name
    splicing factor 1provided by MGI
    Primary source
    MGI:MGI:1095403
    See related
    Ensembl:ENSMUSG00000024949 Vega:OTTMUSG00000018615
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BBP; MZFM; WBP4; Zfp162
    Orthologs
    Location:
    19; 19 A
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (6363279..6378038)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (6363690..6378038)

    Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene multiple endocrine neoplasia 1 Neighboring gene mitogen-activated protein kinase kinase kinase kinase 2 Neighboring gene microRNA 6989 Neighboring gene uncharacterized LOC102634533 Neighboring gene muscle glycogen phosphorylase Neighboring gene RAS, guanyl releasing protein 2 Neighboring gene predicted gene 14965

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    pre-mRNA branch point binding IEA
    Inferred from Electronic Annotation
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    Leydig cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
     
    male sex determination IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear body organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of steroid biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    nuclear body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    splicing factor 1
    Names
    mammalian branch point-binding protein
    transcription factor ZFM1
    zinc finger gene in MEN1 locus
    zinc finger protein 162

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110791.1NP_001104261.1  splicing factor 1 isoform 1

      See identical proteins and their annotated locations for NP_001104261.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA122547, AK147081, AV255405, BX523718, CJ175598
      Consensus CDS
      CCDS50368.1
      UniProtKB/TrEMBL
      Q3UI45
      Related
      ENSMUSP00000121309.1, OTTMUSP00000020161, ENSMUST00000131252.7, OTTMUST00000044802
      Conserved Domains (1) summary
      cl25681
      Location:17257
      SF1-HH; Splicing factor 1 helix-hairpin domain
    2. NM_011750.2NP_035880.2  splicing factor 1 isoform 2

      See identical proteins and their annotated locations for NP_035880.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a different 3' terminal exon compared to variant 1. This results in a novel 3' coding region and 3' UTR compared to variant 1. The encoded isoform (2, also known as 'CW17E' and 'CW17R') is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AA122547, AK157845, AV255405, BX523718, CD563870, CJ175598
      Consensus CDS
      CCDS50369.1
      UniProtKB/TrEMBL
      E9Q4Q2, Q3TZI3
      Related
      ENSMUSP00000109115.1, OTTMUSP00000020160, ENSMUST00000113487.7, OTTMUST00000044801
      Conserved Domains (1) summary
      cl25681
      Location:17257
      SF1-HH; Splicing factor 1 helix-hairpin domain

    RNA

    1. NR_122118.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC167245, AK152914, AV255405, CJ175598

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

      Range
      6363279..6378038
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531734.3XP_006531797.1  splicing factor 1 isoform X2

      Conserved Domains (1) summary
      cl25681
      Location:17257
      SF1-HH; Splicing factor 1 helix-hairpin domain
    2. XM_006531737.3XP_006531800.1  splicing factor 1 isoform X5

      UniProtKB/TrEMBL
      D3YZC9
      Related
      ENSMUSP00000109117.1, OTTMUSP00000029805, ENSMUST00000113489.7, OTTMUST00000060955
      Conserved Domains (1) summary
      cl25681
      Location:17257
      SF1-HH; Splicing factor 1 helix-hairpin domain
    3. XM_006531740.3XP_006531803.1  splicing factor 1 isoform X8

      UniProtKB/TrEMBL
      D3YZD0
      Related
      ENSMUSP00000109116.1, OTTMUSP00000020162, ENSMUST00000113488.7, OTTMUST00000044803
      Conserved Domains (3) summary
      smart00343
      Location:278293
      ZnF_C2HC; zinc finger
      cd02395
      Location:137255
      SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
      pfam16275
      Location:18130
      SF1-HH; Splicing factor 1 helix-hairpin domain
    4. XM_006531735.3XP_006531798.1  splicing factor 1 isoform X3

      Conserved Domains (1) summary
      cl25681
      Location:17257
      SF1-HH; Splicing factor 1 helix-hairpin domain
    5. XM_006531738.3XP_006531801.1  splicing factor 1 isoform X6

      Conserved Domains (1) summary
      cl25681
      Location:17257
      SF1-HH; Splicing factor 1 helix-hairpin domain
    6. XM_006531733.3XP_006531796.1  splicing factor 1 isoform X1

      See identical proteins and their annotated locations for XP_006531796.1

      Conserved Domains (1) summary
      cl25681
      Location:17257
      SF1-HH; Splicing factor 1 helix-hairpin domain
    7. XM_006531736.1XP_006531799.1  splicing factor 1 isoform X4

      Conserved Domains (3) summary
      smart00343
      Location:232247
      ZnF_C2HC; zinc finger
      cd02395
      Location:91209
      SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
      pfam16275
      Location:2784
      SF1-HH; Splicing factor 1 helix-hairpin domain
    8. XM_017318187.1XP_017173676.1  splicing factor 1 isoform X7

    Reference GRCm38.p4 PATCHES

    Genomic

    1. NW_012132910.1 Reference GRCm38.p4 PATCHES

      Range
      180607..194955
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center