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    RBM3 RNA binding motif protein 3 [ Homo sapiens (human) ]

    Gene ID: 5935, updated on 5-Nov-2017
    Official Symbol
    RBM3provided by HGNC
    Official Full Name
    RNA binding motif protein 3provided by HGNC
    Primary source
    HGNC:HGNC:9900
    See related
    Ensembl:ENSG00000102317 MIM:300027; Vega:OTTHUMG00000024121
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RNPL; IS1-RNPL
    Summary
    This gene is a member of the glycine-rich RNA-binding protein family and encodes a protein with one RNA recognition motif (RRM) domain. Expression of this gene is induced by cold shock and low oxygen tension. A pseudogene exists on chromosome 1. Multiple alternatively spliced transcript variants that are predicted to encode different isoforms have been characterized although some of these variants fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    Xp11.23
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) X NC_000023.11 (48574353..48581165)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (48432741..48439553)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene emopamil binding protein (sterol isomerase) Neighboring gene TBC1 domain family member 25 Neighboring gene mitochondrial ribosomal protein L32 pseudogene 1 Neighboring gene WD repeat domain 13

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    RNA processing TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of translation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of translation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    colocalizes_with large ribosomal subunit ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleolus IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Preferred Names
    RNA-binding protein 3
    Names
    RNA binding motif (RNP1, RRM) protein 3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006743.4NP_006734.1  RNA-binding protein 3

      See identical proteins and their annotated locations for NP_006734.1

      Status: REVIEWED

      Source sequence(s)
      AC115618, BC006825
      Consensus CDS
      CCDS14301.1
      UniProtKB/Swiss-Prot
      P98179
      UniProtKB/TrEMBL
      A0A024QYX3
      Related
      ENSP00000365950.3, OTTHUMP00000025800, ENST00000376759.7, OTTHUMT00000060755
      Conserved Domains (1) summary
      cd12449
      Location:685
      RRM_CIRBP_RBM3; RNA recognition motif in cold inducible RNA binding protein (CIRBP), RNA binding motif protein 3 (RBM3) and similar proteins

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p7 Primary Assembly

      Range
      48574353..48581165
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018934.2 Alternate CHM1_1.1

      Range
      48463982..48470795
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001017430.1: Suppressed sequence

      Description
      NM_001017430.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    2. NM_001017431.1: Suppressed sequence

      Description
      NM_001017431.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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