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    OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 [ Homo sapiens (human) ]

    Gene ID: 55611, updated on 22-Apr-2017
    Official Symbol
    OTUB1provided by HGNC
    Official Full Name
    OTU deubiquitinase, ubiquitin aldehyde binding 1provided by HGNC
    Primary source
    HGNC:HGNC:23077
    See related
    Ensembl:ENSG00000167770 MIM:608337; Vega:OTTHUMG00000167786
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OTB1; OTU1; HSPC263
    Summary
    The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    11q13.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 11 NC_000011.10 (63985853..63998420)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (63753325..63765892)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 45, pseudogene Neighboring gene cytochrome c oxidase subunit 8A Neighboring gene uncharacterized LOC101927673 Neighboring gene MACRO domain containing 1 Neighboring gene fibronectin leucine rich transmembrane protein 1

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef HIV-1 Nef downregulates the expression of ubiquitin thioesterase (OTUB1) protein in Nef-transfected SupT1 cells PubMed

    Go to the HIV-1, Human Interaction Database

    • Deubiquitination, organism-specific biosystem (from REACTOME)
      Deubiquitination, organism-specific biosystemUbiquitination, the modification of proteins by the covalent attachment of ubiquitin (Ub), is a key regulatory mechanism for many many cellular processes, including protein degradation by the 26S pro...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Ovarian tumor domain proteases, organism-specific biosystem (from REACTOME)
      Ovarian tumor domain proteases, organism-specific biosystemHumans have 16 Overian tumour domain (OTU) family DUBs that can be evolutionally divided into three classes, the OTUs, the Otubains (OTUBs), and the A20-like OTUs (Komander et al. 2009). OTU family ...
    • Post-translational protein modification, organism-specific biosystem (from REACTOME)
      Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
    • Ub-specific processing proteases, organism-specific biosystem (from REACTOME)
      Ub-specific processing proteases, organism-specific biosystemUb-specific processing proteases (USPs) are the largest of the DUB families with more than 50 members in humans. The USP catalytic domain varies considerably in size and consists of six conserved mo...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Potential readthrough

    Included gene: COX8A

    Homology

    Clone Names

    • MGC4584, FLJ20113, FLJ40710, MGC111158

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NEDD8-specific protease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    thiol-dependent ubiquitin-specific protease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to interleukin-1 IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of double-strand break repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of histone H2A K63-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein K48-linked deubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein deubiquitination TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    ubiquitin thioesterase OTUB1
    Names
    OTU domain, ubiquitin aldehyde binding 1
    OTU domain-containing ubiquitin aldehyde-binding protein 1
    OTU-domain Ubal-binding 1
    deubiquitinating enzyme OTUB1
    otubain-1
    ubiquitin-specific protease otubain 1
    ubiquitin-specific-processing protease OTUB1
    NP_060140.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017670.2NP_060140.2  ubiquitin thioesterase OTUB1

      See identical proteins and their annotated locations for NP_060140.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript.
      Source sequence(s)
      AK098029, AP000721, BC007519, CK906312
      Consensus CDS
      CCDS8055.1
      UniProtKB/Swiss-Prot
      Q96FW1
      UniProtKB/TrEMBL
      B3KUV5
      Related
      ENSP00000444357.1, OTTHUMP00000236860, ENST00000538426.5, OTTHUMT00000396277
      Conserved Domains (1) summary
      pfam10275
      Location:40271
      Peptidase_C65; Peptidase C65 Otubain

    RNA

    1. NR_003089.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), also known as alternative reading frame 1 or ARF-1, includes an alternate segment in the 3' coding region, compared to variant 1, resulting in a frameshift. The nature of the polypeptide, if any, expressed from this transcript has not been experimentally confirmed. This variant is predominantly found in lymphoid tissues.
      Source sequence(s)
      AK098029, AL096714, CK906312
      Related
      ENST00000301453.7

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p7 Primary Assembly

      Range
      63985853..63998420
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018922.2 Alternate CHM1_1.1

      Range
      63636649..63649224
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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