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    PRC1 protein regulator of cytokinesis 1 [ Homo sapiens (human) ]

    Gene ID: 9055, updated on 5-Nov-2017
    Official Symbol
    PRC1provided by HGNC
    Official Full Name
    protein regulator of cytokinesis 1provided by HGNC
    Primary source
    HGNC:HGNC:9341
    See related
    Ensembl:ENSG00000198901 MIM:603484; Vega:OTTHUMG00000171685
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ASE1
    Summary
    This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
    Expression
    Broad expression in bone marrow (RPKM 31.0), testis (RPKM 24.4) and 18 other tissues See more
    Orthologs
    Location:
    15q26.1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 15 NC_000015.10 (90966038..90994651, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (91509268..91537881, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene unc-45 myosin chaperone A Neighboring gene HD domain containing 3 Neighboring gene RCC1 domain containing 1 Neighboring gene PRC1 antisense RNA 1 Neighboring gene VPS33B, late endosome and lysosome associated Neighboring gene uncharacterized LOC105370970 Neighboring gene VPS33B divergent transcript

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1.
    NHGRI GWA Catalog
    Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
    NHGRI GWA Catalog
    Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
    NHGRI GWA Catalog
    • RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
      RHO GTPase Effectors, organism-specific biosystemRHO GTPases regulate cell behaviour by activating a number of downstream effectors that regulate cytoskeletal organization, intracellular trafficking and transcription (reviewed by Sahai and Marshall...
    • RHO GTPases activate CIT, organism-specific biosystem (from REACTOME)
      RHO GTPases activate CIT, organism-specific biosystemCitron kinase (CIT) or citron RHO-interacting kinase (CRIK) shares similarities with ROCK kinases. Like ROCK, it consists of a serine/threonine kinase domain, a coiled-coil region, a RHO-binding doma...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
      Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC1671, MGC3669

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    kinesin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    microtubule binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cytokinesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule bundle formation IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic spindle elongation TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    contractile ring IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
     
    midbody IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    spindle microtubule TAS
    Traceable Author Statement
    more info
    PubMed 
    spindle pole IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    protein regulator of cytokinesis 1
    Names
    anaphase spindle elongation 1 homolog
    protein regulating cytokinesis 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_050647.1 RefSeqGene

      Range
      5001..33614
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001267580.1NP_001254509.1  protein regulator of cytokinesis 1 isoform 4

      See identical proteins and their annotated locations for NP_001254509.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region, and uses and alternate splice site and lacks an exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (4) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC068831, AK297117, BX647317, DA655494, DW423775
      Consensus CDS
      CCDS45353.2
      UniProtKB/Swiss-Prot
      O43663
      Related
      ENSP00000409549.2, OTTHUMP00000246706, ENST00000442656.6, OTTHUMT00000414762
      Conserved Domains (3) summary
      pfam03999
      Location:22519
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
      pfam08418
      Location:372510
      Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal
      cl00711
      Location:219370
      Glyco_hydro_77; 4-alpha-glucanotransferase
    2. NM_003981.3NP_003972.1  protein regulator of cytokinesis 1 isoform 1

      See identical proteins and their annotated locations for NP_003972.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AF044588, BC003138, BX647317, DA655494, DW423775
      Consensus CDS
      CCDS32334.1
      UniProtKB/Swiss-Prot
      O43663
      UniProtKB/TrEMBL
      A0A024RC67
      Related
      ENSP00000377793.3, OTTHUMP00000246702, ENST00000394249.7, OTTHUMT00000414757
      Conserved Domains (3) summary
      pfam03999
      Location:37615
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
      pfam08418
      Location:413551
      Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal
      cl00711
      Location:260411
      Glyco_hydro_77; 4-alpha-glucanotransferase
    3. NM_199413.2NP_955445.1  protein regulator of cytokinesis 1 isoform 2

      See identical proteins and their annotated locations for NP_955445.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
      Source sequence(s)
      AC068831, AK312600, BX647317, DA655494, DW423775
      Consensus CDS
      CCDS45352.1
      Related
      ENSP00000354679.5, OTTHUMP00000246704, ENST00000361188.9, OTTHUMT00000414760
      Conserved Domains (3) summary
      pfam03999
      Location:37601
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
      pfam08418
      Location:413551
      Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal
      cl00711
      Location:260411
      Glyco_hydro_77; 4-alpha-glucanotransferase

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p7 Primary Assembly

      Range
      90966038..90994651 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017022715.1XP_016878204.1  protein regulator of cytokinesis 1 isoform X7

    2. XM_011522192.1XP_011520494.1  protein regulator of cytokinesis 1 isoform X13

      Conserved Domains (4) summary
      pfam03999
      Location:37494
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
      pfam08418
      Location:306444
      Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal
      pfam13094
      Location:35180
      CENP-Q; CENP-Q, a CENPA-CAD centromere complex subunit
      cl00711
      Location:141304
      Glyco_hydro_77; 4-alpha-glucanotransferase
    3. XM_017022716.1XP_016878205.1  protein regulator of cytokinesis 1 isoform X12

    4. XM_017022713.1XP_016878202.1  protein regulator of cytokinesis 1 isoform X5

    5. XM_011522189.1XP_011520491.1  protein regulator of cytokinesis 1 isoform X3

      Conserved Domains (2) summary
      pfam03999
      Location:37564
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
      cl00711
      Location:260411
      Glyco_hydro_77; 4-alpha-glucanotransferase
    6. XM_017022712.1XP_016878201.1  protein regulator of cytokinesis 1 isoform X4

    7. XM_006720760.1XP_006720823.1  protein regulator of cytokinesis 1 isoform X11

      Conserved Domains (3) summary
      pfam03999
      Location:37562
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
      pfam08418
      Location:413562
      Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal
      cl00711
      Location:260411
      Glyco_hydro_77; 4-alpha-glucanotransferase
    8. XM_006720759.1XP_006720822.1  protein regulator of cytokinesis 1 isoform X10

      See identical proteins and their annotated locations for XP_006720822.1

      Conserved Domains (3) summary
      pfam03999
      Location:37549
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
      pfam08418
      Location:413560
      Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal
      cl00711
      Location:260411
      Glyco_hydro_77; 4-alpha-glucanotransferase
    9. XM_011522187.1XP_011520489.1  protein regulator of cytokinesis 1 isoform X1

      Conserved Domains (3) summary
      pfam03999
      Location:37601
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
      pfam08418
      Location:413551
      Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal
      cl00711
      Location:260411
      Glyco_hydro_77; 4-alpha-glucanotransferase
    10. XM_017022717.1XP_016878206.1  protein regulator of cytokinesis 1 isoform X14

    11. XM_005254987.2XP_005255044.1  protein regulator of cytokinesis 1 isoform X8

      Conserved Domains (3) summary
      pfam03999
      Location:37560
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
      pfam08418
      Location:413551
      Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal
      cl00711
      Location:260411
      Glyco_hydro_77; 4-alpha-glucanotransferase
    12. XM_011522191.2XP_011520493.1  protein regulator of cytokinesis 1 isoform X10

      See identical proteins and their annotated locations for XP_011520493.1

      Conserved Domains (3) summary
      pfam03999
      Location:37549
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
      pfam08418
      Location:413560
      Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal
      cl00711
      Location:260411
      Glyco_hydro_77; 4-alpha-glucanotransferase
    13. XM_011522188.2XP_011520490.1  protein regulator of cytokinesis 1 isoform X2

      Conserved Domains (3) summary
      pfam03999
      Location:37583
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
      pfam08418
      Location:413551
      Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal
      cl00711
      Location:260411
      Glyco_hydro_77; 4-alpha-glucanotransferase
    14. XM_017022714.1XP_016878203.1  protein regulator of cytokinesis 1 isoform X6

    15. XM_011522190.2XP_011520492.1  protein regulator of cytokinesis 1 isoform X9

      Conserved Domains (4) summary
      pfam03999
      Location:37544
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
      pfam08418
      Location:356494
      Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal
      pfam13094
      Location:35194
      CENP-Q; CENP-Q, a CENPA-CAD centromere complex subunit
      cl00711
      Location:203354
      Glyco_hydro_77; 4-alpha-glucanotransferase

    Alternate CHM1_1.1

    Genomic

    1. NC_018926.2 Alternate CHM1_1.1

      Range
      91350870..91379451 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_199414.1: Suppressed sequence

      Description
      NM_199414.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Support Center