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    FASN fatty acid synthase [ Homo sapiens (human) ]

    Gene ID: 2194, updated on 6-Aug-2017
    Official Symbol
    FASNprovided by HGNC
    Official Full Name
    fatty acid synthaseprovided by HGNC
    Primary source
    HGNC:HGNC:3594
    See related
    Ensembl:ENSG00000169710 MIM:600212; Vega:OTTHUMG00000178527
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAS; OA-519; SDR27X1
    Summary
    The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    17q25.3
    Exon count:
    43
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 17 NC_000017.11 (82078338..82098303, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (80036214..80056106, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Neighboring gene G protein pathway suppressor 1 Neighboring gene dihydrouridine synthase 1 like Neighboring gene small nucleolar RNA, C/D box 134 Neighboring gene coiled-coil domain containing 57 Neighboring gene solute carrier family 16 member 3 Neighboring gene microRNA 6787

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify fatty acid synthase (FASN), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify fatty acid synthase (FASN), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify fatty acid synthase (FASN), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Cellular biotinylated fatty acid synthase protein (FASN) is incorporated into HIV-1 Gag virus-like particles PubMed
    gag Tandem affinity purification and mass spectrometry analysis identify fatty acid synthase (FASN), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC14367, MGC15706

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
     
    3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
     
    3-oxo-glutaryl-[acp] methyl ester reductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    3-oxo-pimeloyl-[acp] methyl ester reductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
     
    3-oxoacyl-[acyl-carrier-protein] synthase activity IEA
    Inferred from Electronic Annotation
    more info
     
    NADPH binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    [acyl-carrier-protein] S-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    [acyl-carrier-protein] S-malonyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    cadherin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    drug binding IEA
    Inferred from Electronic Annotation
    more info
     
    enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity IEA
    Inferred from Electronic Annotation
    more info
     
    enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity IEA
    Inferred from Electronic Annotation
    more info
     
    fatty acid synthase activity TAS
    Traceable Author Statement
    more info
     
    myristoyl-[acyl-carrier-protein] hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    oleoyl-[acyl-carrier-protein] hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    palmitoyl-[acyl-carrier-protein] hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    phosphopantetheine binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acetyl-CoA metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to interleukin-4 IEA
    Inferred from Electronic Annotation
    more info
     
    fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    fatty acid metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    fatty-acyl-CoA biosynthetic process TAS
    Traceable Author Statement
    more info
     
    mammary gland development IEA
    Inferred from Electronic Annotation
    more info
     
    osteoblast differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    pantothenate metabolic process TAS
    Traceable Author Statement
    more info
     
    positive regulation of cellular metabolic process TAS
    Traceable Author Statement
    more info
     
    regulation of cholesterol biosynthetic process TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glycogen granule IEA
    Inferred from Electronic Annotation
    more info
     
    melanosome IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    Preferred Names
    fatty acid synthase
    Names
    short chain dehydrogenase/reductase family 27X, member 1
    NP_004095.4
    XP_011521840.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004104.4NP_004095.4  fatty acid synthase

      See identical proteins and their annotated locations for NP_004095.4

      Status: REVIEWED

      Source sequence(s)
      BC007267, BC021544, BC063242, S80437
      Consensus CDS
      CCDS11801.1
      UniProtKB/Swiss-Prot
      P49327
      Related
      ENSP00000304592.2, OTTHUMP00000259630, ENST00000306749.3, OTTHUMT00000442369
      Conserved Domains (11) summary
      cd05195
      Location:15661854
      enoyl_red; enoyl reductase of polyketide synthase
      cd08954
      Location:18762112
      KR_1_FAS_SDR_x; beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 1, complex (x) SDRs
      smart00823
      Location:21112179
      PKS_PP; Phosphopantetheine attachment site
      smart00829
      Location:15641854
      PKS_ER; Enoylreductase
      COG3321
      Location:11022
      PksD; Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism]
      cd00833
      Location:2404
      PKS; polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or ...
      pfam00698
      Location:493810
      Acyl_transf_1; Acyl transferase domain
      pfam00975
      Location:22422488
      Thioesterase; Thioesterase domain
      pfam08242
      Location:12431342
      Methyltransf_12; Methyltransferase domain
      pfam16197
      Location:362474
      KAsynt_C_assoc; Ketoacyl-synthetase C-terminal extension
      cl00509
      Location:8741105
      hot_dog; The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p7 Primary Assembly

      Range
      82078338..82098303 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011523538.2XP_011521840.1  fatty acid synthase isoform X1

      See identical proteins and their annotated locations for XP_011521840.1

      UniProtKB/Swiss-Prot
      P49327
      Conserved Domains (11) summary
      cd05195
      Location:15661854
      enoyl_red; enoyl reductase of polyketide synthase
      cd08954
      Location:18762112
      KR_1_FAS_SDR_x; beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 1, complex (x) SDRs
      smart00823
      Location:21112179
      PKS_PP; Phosphopantetheine attachment site
      smart00829
      Location:15641854
      PKS_ER; Enoylreductase
      COG3321
      Location:11022
      PksD; Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism]
      cd00833
      Location:2404
      PKS; polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or ...
      pfam00698
      Location:493810
      Acyl_transf_1; Acyl transferase domain
      pfam00975
      Location:22422488
      Thioesterase; Thioesterase domain
      pfam08242
      Location:12431342
      Methyltransf_12; Methyltransferase domain
      pfam16197
      Location:362474
      KAsynt_C_assoc; Ketoacyl-synthetase C-terminal extension
      cl00509
      Location:8741105
      hot_dog; The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated ...

    Alternate CHM1_1.1

    Genomic

    1. NC_018928.2 Alternate CHM1_1.1

      Range
      80122440..80142272 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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