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    CDC25 Rhodanese/Cell cycle control phosphatase superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831832, updated on 5-Nov-2017
    Gene symbol
    CDC25
    Gene description
    Rhodanese/Cell cycle control phosphatase superfamily protein
    Primary source
    Araport:AT5G03455
    Locus tag
    AT5G03455
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ACR2; ARATH;CDC25; ARSENATE REDUCTASE; ARSENATE REDUCTASE 2; AtACR2
    Summary
    Encodes a homolog of yeast cell cycle regulator CDC25. It has a sole catalytic domain and devoid of the N-terminal regulatory region found in the human CDC25 and is capable of reducing the mitotic cell length of transformed fission yeast. Non-plant CDC25 proteins have been shown to do this. However, the gene is more or less constant, regardless of whether the tissue examined contained proliferative cells. Also described as having arsenate reductase activity involved in arsenate resistance.
    Location:
    chromosome: 5
    Exon count:
    3
    Sequence:
    Chromosome: 5; NC_003076.8 (862556..864176)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene tRNA Neighboring gene transmembrane protein Neighboring gene Protein phosphatase 2A regulatory B subunit family protein Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description
    NM_120425.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    arsenate reductase (glutaredoxin) activity IEA
    Inferred from Electronic Annotation
    more info
     
    arsenate reductase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to arsenic-containing substance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT response to arsenic-containing substance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    chloroplast IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISM
    Inferred from Sequence Model
    more info
     
    Names
    Rhodanese/Cell cycle control phosphatase superfamily protein
    NP_568119.1
    • CDC25; FUNCTIONS IN: protein tyrosine phosphatase activity, arsenate reductase activity; INVOLVED IN: protein amino acid phosphorylation, response to arsenic; LOCATED IN: chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Rhodanese-like (InterPro:IPR001763); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      862556..864176
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001342706.1NP_001331919.1  Rhodanese/Cell cycle control phosphatase superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BFF8
    2. NM_120425.3NP_568119.1  Rhodanese/Cell cycle control phosphatase superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568119.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8GY31
      Conserved Domains (1) summary
      cd01531
      Location:21130
      Acr2p; Eukaryotic arsenate resistance proteins are members of the Rhodanese Homology Domain superfamily. Included in this CD is the Saccharomyces cerevisiae arsenate reductase protein, Acr2p, and other yeast and plant homologs.
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