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    Pms2 postmeiotic segregation increased 2 (S. cerevisiae) [ Mus musculus (house mouse) ]

    Gene ID: 18861, updated on 22-Apr-2017
    Official Symbol
    Pms2provided by MGI
    Official Full Name
    postmeiotic segregation increased 2 (S. cerevisiae)provided by MGI
    Primary source
    MGI:MGI:104288
    See related
    Ensembl:ENSMUSG00000075569 Ensembl:ENSMUSG00000079109 Vega:OTTMUSG00000035941; Vega:OTTMUSG00000054938
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pmsl2; AW555130
    Location:
    5 82.82 cM; 5 G2
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (143909901..143985719)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (144670870..144692625)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 2 alpha kinase 1 Neighboring gene ankyrin repeat domain 61 Neighboring gene aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 Neighboring gene predicted gene 17135 Neighboring gene CCZ1 vacuolar protein trafficking and biogenesis associated Neighboring gene predicted gene, 33427

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to MutSalpha complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    mismatched DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    nuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    single base insertion or deletion binding ISO
    Inferred from Sequence Orthology
    more info
     
    single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    contributes_to single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to DNA damage stimulus IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cellular response to DNA damage stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    meiotic cell cycle TAS
    Traceable Author Statement
    more info
    PubMed 
    mismatch repair IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    mismatch repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mismatch repair ISO
    Inferred from Sequence Orthology
    more info
     
    mismatch repair TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of isotype switching to IgA isotypes IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of isotype switching to IgA isotypes IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of isotype switching to IgG isotypes IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of isotype switching to IgG isotypes IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    somatic hypermutation of immunoglobulin genes IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    somatic recombination of immunoglobulin gene segments IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    MutLalpha complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    P-body ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    mismatch repair complex IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    mismatch repair endonuclease PMS2
    Names
    DNA mismatch repair protein PMS2
    PMS1 protein homolog 2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008886.2NP_032912.2  mismatch repair endonuclease PMS2

      See identical proteins and their annotated locations for NP_032912.2

      Status: VALIDATED

      Source sequence(s)
      BC066110, BC086637
      Consensus CDS
      CCDS39375.1
      UniProtKB/TrEMBL
      B9EJ22
      Related
      ENSMUSP00000119875.1, OTTMUSP00000031008, ENSMUST00000148011.7, OTTMUST00000062771
      Conserved Domains (4) summary
      smart00853
      Location:675818
      MutL_C; MutL C terminal dimerisation domain
      cd03484
      Location:223364
      MutL_Trans_hPMS_2_like; MutL_Trans_hPMS2_like: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to human PSM2 (hPSM2). hPSM2 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second ...
      TIGR00585
      Location:13344
      mutl; DNA mismatch repair protein MutL
      cl00075
      Location:34139
      HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      143909901..143985719
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320714.1XP_017176203.1  mismatch repair endonuclease PMS2 isoform X7

    2. XM_006504812.2XP_006504875.1  mismatch repair endonuclease PMS2 isoform X3

      See identical proteins and their annotated locations for XP_006504875.1

      Conserved Domains (2) summary
      smart00853
      Location:492635
      MutL_C; MutL C terminal dimerisation domain
      cd03484
      Location:40181
      MutL_Trans_hPMS_2_like; MutL_Trans_hPMS2_like: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to human PSM2 (hPSM2). hPSM2 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second ...
    3. XM_017320710.1XP_017176199.1  mismatch repair endonuclease PMS2 isoform X3

      Conserved Domains (2) summary
      smart00853
      Location:492635
      MutL_C; MutL C terminal dimerisation domain
      cd03484
      Location:40181
      MutL_Trans_hPMS_2_like; MutL_Trans_hPMS2_like: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to human PSM2 (hPSM2). hPSM2 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second ...
    4. XM_011241007.1XP_011239309.1  mismatch repair endonuclease PMS2 isoform X1

      See identical proteins and their annotated locations for XP_011239309.1

      Related
      ENSMUSP00000132687.1, OTTMUSP00000050898, ENSMUST00000166847.7, OTTMUST00000092194
      Conserved Domains (4) summary
      smart00698
      Location:225244
      MORN; Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases
      COG4642
      Location:122334
      COG4642; Uncharacterized conserved protein [Function unknown]
      pfam02493
      Location:284306
      MORN; MORN repeat
      cl23750
      Location:782829
      vATP-synt_E; ATP synthase (E/31 kDa) subunit
    5. XM_017320709.1XP_017176198.1  mismatch repair endonuclease PMS2 isoform X2

    6. XM_011241009.1XP_011239311.1  mismatch repair endonuclease PMS2 isoform X4

      Conserved Domains (3) summary
      smart00698
      Location:4667
      MORN; Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases
      pfam02493
      Location:2547
      MORN; MORN repeat
      cl23750
      Location:523570
      vATP-synt_E; ATP synthase (E/31 kDa) subunit
    7. XM_011241008.1XP_011239310.1  mismatch repair endonuclease PMS2 isoform X1

      See identical proteins and their annotated locations for XP_011239310.1

      Conserved Domains (4) summary
      smart00698
      Location:225244
      MORN; Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases
      COG4642
      Location:122334
      COG4642; Uncharacterized conserved protein [Function unknown]
      pfam02493
      Location:284306
      MORN; MORN repeat
      cl23750
      Location:782829
      vATP-synt_E; ATP synthase (E/31 kDa) subunit
    8. XM_017320713.1XP_017176202.1  mismatch repair endonuclease PMS2 isoform X6

      Related
      ENSMUSP00000148444.1, OTTMUSP00000078373, ENSMUST00000212711.1, OTTMUST00000151131
    9. XM_017320711.1XP_017176200.1  mismatch repair endonuclease PMS2 isoform X4

      Conserved Domains (3) summary
      smart00698
      Location:4667
      MORN; Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases
      pfam02493
      Location:2547
      MORN; MORN repeat
      cl23750
      Location:523570
      vATP-synt_E; ATP synthase (E/31 kDa) subunit
    10. XM_017320712.1XP_017176201.1  mismatch repair endonuclease PMS2 isoform X5

    RNA

    1. XR_001784634.1 RNA Sequence

    2. XR_377191.3 RNA Sequence

    3. XR_001784637.1 RNA Sequence

    4. XR_001784636.1 RNA Sequence

    5. XR_001784639.1 RNA Sequence

    6. XR_001784638.1 RNA Sequence

    7. XR_001784635.1 RNA Sequence

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