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    daf-16 Forkhead box protein O [ Caenorhabditis elegans ]

    Gene ID: 172981, updated on 6-Aug-2017
    Gene symbol
    daf-16
    Gene description
    Forkhead box protein O
    Primary source
    WormBase:WBGene00000912
    Locus tag
    CELE_R13H8.1
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    See daf-16 in Map Viewer
    Location:
    chromosome: I
    Exon count:
    15
    Sequence:
    Chromosome: I; NC_003279.8 (10750498..10775050)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Galactoside 2-alpha-L-fucosyltransferase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Glutathione PeroXidase

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    14-3-3 protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    DEAD/H-box RNA helicase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    activating transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    beta-catenin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor activity, sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor activity, sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin-specific protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    aging IDA
    Inferred from Direct Assay
    more info
    PubMed 
    aging IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to DNA damage stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to heat IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to oxidative stress IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    dauer entry IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    dauer larval development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    defense response IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    determination of adult lifespan IDA
    Inferred from Direct Assay
    more info
    PubMed 
    determination of adult lifespan IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    determination of adult lifespan IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    NOT determination of adult lifespan IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT heat acclimation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    NOT heat acclimation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    insulin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    insulin receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    lipid storage IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nematode larval development IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of adaptive immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of dauer larval development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of DNA-templated transcription in response to stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell cycle process IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    regulation of dauer larval development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of growth IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of lipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    response to UV IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to heat IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    short-term memory IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Names
    Forkhead box protein O
    hypothetical protein
    NP_001021593.1
    • Confirmed by transcript evidence
    NP_001021594.1
    • Confirmed by transcript evidence
    NP_001021595.1
    • Confirmed by transcript evidence
    NP_001021596.1
    • Confirmed by transcript evidence
    NP_001021597.1
    • Confirmed by transcript evidence
    NP_001021598.2
    • Confirmed by transcript evidence
    NP_001251490.1
    • Confirmed by transcript evidence
    NP_001251492.1
    • Confirmed by transcript evidence
    NP_001300402.1
    • Confirmed by transcript evidence
    NP_001300403.1
    • Confirmed by transcript evidence
    NP_001300433.1
    • Confirmed by transcript evidence
    NP_001300434.1
    • Confirmed by transcript evidence

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      10750498..10775050
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001264561.1NP_001251490.1  Forkhead box protein O [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001251490.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O16850
      Conserved Domains (1) summary
      cd00059
      Location:175255
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    2. NM_001026427.4NP_001021598.2  Forkhead box protein O [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021598.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O16850
      Conserved Domains (1) summary
      cd00059
      Location:151231
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    3. NM_001313473.1NP_001300402.1  Uncharacterized protein CELE_R13H8.1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AWG6
      Conserved Domains (1) summary
      cd00059
      Location:149229
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    4. NM_001026425.3NP_001021596.1  Forkhead box protein O [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021596.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O16850
      Conserved Domains (1) summary
      cd00059
      Location:121201
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    5. NM_001313474.1NP_001300403.1  Uncharacterized protein CELE_R13H8.1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AR63
      Conserved Domains (1) summary
      cd00059
      Location:119199
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    6. NM_001026424.4NP_001021595.1  Forkhead box protein O [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021595.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O16850
      Conserved Domains (1) summary
      cd00059
      Location:144224
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    7. NM_001026423.4NP_001021594.1  Forkhead box protein O [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021594.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O16850
      Conserved Domains (1) summary
      cd00059
      Location:142222
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    8. NM_001313504.1NP_001300433.1  Uncharacterized protein CELE_R13H8.1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AR95
      Conserved Domains (1) summary
      cd00059
      Location:41121
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    9. NM_001313505.1NP_001300434.1  Uncharacterized protein CELE_R13H8.1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ATP5
      Conserved Domains (1) summary
      cd00059
      Location:39119
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    10. NM_001026422.4NP_001021593.1  Forkhead box protein O [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021593.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O16850
      Conserved Domains (1) summary
      smart00339
      Location:164249
      FH; FORKHEAD
    11. NM_001264563.1NP_001251492.1  Forkhead box protein O [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001251492.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O16850
      Conserved Domains (1) summary
      cl00061
      Location:943
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    12. NM_001026426.2NP_001021597.1  Forkhead box protein O [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021597.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O16850
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