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    CCL18 C-C motif chemokine ligand 18 [ Homo sapiens (human) ]

    Gene ID: 6362, updated on 21-May-2017
    Official Symbol
    CCL18provided by HGNC
    Official Full Name
    C-C motif chemokine ligand 18provided by HGNC
    Primary source
    HGNC:HGNC:10616
    See related
    Ensembl:ENSG00000275385 MIM:603757; Vega:OTTHUMG00000188410
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CKb7; PARC; AMAC1; DCCK1; MIP-4; AMAC-1; DC-CK1; SCYA18
    Summary
    This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for naive T cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes. This chemokine attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It may play a role in both humoral and cell-mediated immunity responses. [provided by RefSeq, Sep 2014]
    Orthologs
    Location:
    17q12
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 17 NC_000017.11 (36064272..36071481)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (34391643..34398841)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985068 Neighboring gene C-C motif chemokine ligand 23 Neighboring gene uncharacterized LOC105371746 Neighboring gene uncharacterized LOC102724850 Neighboring gene uncharacterized LOC101927369 Neighboring gene C-C motif chemokine ligand 3 Neighboring gene C-C motif chemokine ligand 4

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Chemokine signaling pathway, organism-specific biosystem (from KEGG)
      Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Chemokine signaling pathway, conserved biosystem (from KEGG)
      Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    CCR chemokine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    chemokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cell communication TAS
    Traceable Author Statement
    more info
    PubMed 
    cell-cell signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    cellular response to interferon-gamma IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cellular response to interleukin-1 IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cellular response to tumor necrosis factor IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    chemokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    chemotaxis TAS
    Traceable Author Statement
    more info
    PubMed 
    immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    lymphocyte chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    monocyte chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    neutrophil chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    response to biotic stimulus TAS
    Traceable Author Statement
    more info
    PubMed 
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    C-C motif chemokine 18
    Names
    CC chemokine PARC
    CC chemokine ligand 18
    alternative macrophage activation-associated CC chemokine 1
    chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
    chemokine (C-C), dendritic
    dendritic cell chemokine 1
    macrophage inflammatory protein 4
    pulmonary and activation-regulated chemokine
    small inducible cytokine A18
    small inducible cytokine subfamily A (Cys-Cys), member 18, pulmonary and activation-regulated

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002988.3NP_002979.1  C-C motif chemokine 18 precursor

      See identical proteins and their annotated locations for NP_002979.1

      Status: REVIEWED

      Source sequence(s)
      AC243829, BC096124, BU617136
      Consensus CDS
      CCDS11306.1
      UniProtKB/Swiss-Prot
      P55774
      Related
      ENSP00000479955.1, OTTHUMP00000276533, ENST00000616054.1, OTTHUMT00000477135
      Conserved Domains (1) summary
      smart00199
      Location:3085
      SCY; Intercrine alpha family (small cytokine C-X-C) (chemokine CXC)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p7 Primary Assembly

      Range
      36064272..36071481
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p7 ALT_REF_LOCI_1

    Genomic

    1. NT_187614.1 Reference GRCh38.p7 ALT_REF_LOCI_1

      Range
      299160..306369
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p7 ALT_REF_LOCI_2

    Genomic

    1. NT_187661.1 Reference GRCh38.p7 ALT_REF_LOCI_2

      Range
      18369..25578
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018928.2 Alternate CHM1_1.1

      Range
      34455843..34463052
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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