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    Crh corticotropin releasing hormone [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81648, updated on 11-Jun-2017
    Official Symbol
    Crhprovided by RGD
    Official Full Name
    corticotropin releasing hormoneprovided by RGD
    Primary source
    RGD:620505
    See related
    Ensembl:ENSRNOG00000012703
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CRF
    Summary
    binds CRH receptors and mediates neuroendocrine stress response; may play a role in the consolidation of long term memory [RGD, Feb 2006]
    Orthologs
    Location:
    2q24
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (104459999..104461863, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (124182919..124184783, complement)

    Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene transfer RNA alanine (anticodon AGC) Neighboring gene tripartite motif-containing 55 Neighboring gene similar to CCR4-NOT transcription complex, subunit 8 Neighboring gene succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial pseudogene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    corticotropin-releasing hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    corticotropin-releasing hormone receptor 1 binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    corticotropin-releasing hormone receptor 1 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    corticotropin-releasing hormone receptor 2 binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    corticotropin-releasing hormone receptor 2 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    neuropeptide hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    adrenal gland development IEA
    Inferred from Electronic Annotation
    more info
     
    adrenal gland development ISO
    Inferred from Sequence Orthology
    more info
     
    associative learning IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to cocaine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to dexamethasone stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    diterpenoid metabolic process IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    female pregnancy IEA
    Inferred from Electronic Annotation
    more info
     
    female pregnancy ISO
    Inferred from Sequence Orthology
    more info
     
    glucocorticoid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    glucocorticoid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    hormone-mediated apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hypothalamus development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    ion homeostasis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    learning or memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    locomotory exploration behavior IEA
    Inferred from Electronic Annotation
    more info
     
    locomotory exploration behavior ISO
    Inferred from Sequence Orthology
    more info
     
    long-term synaptic potentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lung development IEA
    Inferred from Electronic Annotation
    more info
     
    lung development ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of blood pressure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cell death IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of epinephrine secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of glucagon secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of luteinizing hormone secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of norepinephrine secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of behavioral fear response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cAMP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of calcium ion import IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell death IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of corticosterone secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of corticosterone secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of corticotropin secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of corticotropin secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cortisol secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of cortisol secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of digestive system process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of insulin secretion involved in cellular response to glucose stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of NMDA receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of NMDA receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of serotonin secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to cocaine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to corticosterone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to estrogen IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to ethanol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to ether IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to immobilization stress IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    NOT response to immobilization stress IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to pain IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    steroid metabolic process IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    synaptic transmission, dopaminergic IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptic transmission, dopaminergic ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space TAS
    Traceable Author Statement
    more info
    PubMed 
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perikaryon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    varicosity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    corticoliberin
    Names
    corticotropin-releasing factor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031019.1NP_112281.1  corticoliberin precursor

      See identical proteins and their annotated locations for NP_112281.1

      Status: PROVISIONAL

      Source sequence(s)
      M54987
      UniProtKB/Swiss-Prot
      P01143
      Related
      ENSRNOP00000016953.1, ENSRNOT00000016953.2
      Conserved Domains (1) summary
      pfam00473
      Location:148185
      CRF; Corticotropin-releasing factor family

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

      Range
      104459999..104461863 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000070.1 Alternate Rn_Celera

      Range
      97536796..97538660 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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