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    ACADSB acyl-CoA dehydrogenase, short/branched chain [ Homo sapiens (human) ]

    Gene ID: 36, updated on 9-Jul-2017
    Official Symbol
    ACADSBprovided by HGNC
    Official Full Name
    acyl-CoA dehydrogenase, short/branched chainprovided by HGNC
    Primary source
    HGNC:HGNC:91
    See related
    Ensembl:ENSG00000196177 MIM:600301; Vega:OTTHUMG00000019200
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ACAD7; SBCAD; 2-MEBCAD
    Summary
    Short/branched chain acyl-CoA dehydrogenase(ACADSB) is a member of the acyl-CoA dehydrogenase family of enzymes that catalyze the dehydrogenation of acyl-CoA derivatives in the metabolism of fatty acids or branch chained amino acids. Substrate specificity is the primary characteristic used to define members of this gene family. The ACADSB gene product has the greatest activity towards the short branched chain acyl-CoA derivative, (S)-2-methylbutyryl-CoA, but also reacts significantly with other 2-methyl branched chain substrates and with short straight chain acyl-CoAs. The cDNA encodes for a mitochondrial precursor protein which is cleaved upon mitochondrial import and predicted to yield a mature peptide of approximately 43.7-KDa. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    10q26.13
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 10 NC_000010.11 (123008913..123058290)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (124768429..124817806)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene chromosome 10 open reading frame 88 Neighboring gene phosphoseryl-tRNA kinase Neighboring gene IKAROS family zinc finger 5 Neighboring gene H6 family homeobox 3 Neighboring gene H6 family homeobox 2

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Replication interactions

    Interaction Pubs
    Knockdown of acyl-CoA dehydrogenase, short/branched chain (ACADSB) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    acyl-CoA dehydrogenase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    branched-chain amino acid catabolic process TAS
    Traceable Author Statement
    more info
     
    fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial matrix TAS
    Traceable Author Statement
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
     
    Preferred Names
    short/branched chain specific acyl-CoA dehydrogenase, mitochondrial
    Names
    2-methyl branched chain acyl-CoA dehydrogenase
    2-methylbutyryl-coenzyme A dehydrogenase
    acyl-Coenzyme A dehydrogenase, short/branched chain
    NP_001600.1
    XP_016871683.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008003.1 RefSeqGene

      Range
      5001..54378
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_451

    mRNA and Protein(s)

    1. NM_001330174.1NP_001317103.1  short/branched chain specific acyl-CoA dehydrogenase, mitochondrial isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC012391, AW408417, BC032395, BQ312626, DA964130, DC412570, H56072
      Consensus CDS
      CCDS81518.1
      UniProtKB/Swiss-Prot
      P45954
    2. NM_001609.3NP_001600.1  short/branched chain specific acyl-CoA dehydrogenase, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_001600.1

      Status: REVIEWED

      Source sequence(s)
      AC012391, BC013756, DA964130, U12778
      Consensus CDS
      CCDS7634.1
      UniProtKB/Swiss-Prot
      P45954
      UniProtKB/TrEMBL
      A0A0S2Z3P9
      Related
      ENSP00000357873.3, OTTHUMP00000020685, ENST00000358776.6, OTTHUMT00000050843
      Conserved Domains (2) summary
      cd01158
      Location:59430
      SCAD_SBCAD; Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases
      COG1960
      Location:57428
      CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p7 Primary Assembly

      Range
      123008913..123058290
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017016194.1XP_016871683.1  short/branched chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1

      Related
      ENSP00000357862.4, OTTHUMP00000240061, ENST00000368869.8, OTTHUMT00000402204
      Conserved Domains (2) summary
      cd01158
      Location:1328
      SCAD_SBCAD; Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases
      COG1960
      Location:1326
      CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]

    Alternate CHM1_1.1

    Genomic

    1. NC_018921.2 Alternate CHM1_1.1

      Range
      125050159..125099529
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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