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    Lin28a lin-28 homolog A (C. elegans) [ Mus musculus (house mouse) ]

    Gene ID: 83557, updated on 22-Apr-2017
    Official Symbol
    Lin28aprovided by MGI
    Official Full Name
    lin-28 homolog A (C. elegans)provided by MGI
    Primary source
    MGI:MGI:1890546
    See related
    Ensembl:ENSMUSG00000050966 Vega:OTTMUSG00000010211
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lin28; Tex17; Lin-28; Gm10299; lin-28A; AL024421
    Orthologs
    Location:
    4; 4 D3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (134003330..134019202, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (133559245..133574731, complement)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene high mobility group nucleosomal binding domain 2 Neighboring gene dehydrodolichyl diphosphate synthase Neighboring gene zinc finger protein 683 Neighboring gene absent in melanoma 1-like

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    G-quadruplex RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    miRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    sequence-specific mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    translation initiation factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    RNA 3'-end processing ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to glucose stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    gene silencing by RNA IEA
    Inferred from Electronic Annotation
    more info
     
    germ cell development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    germ cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    miRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    miRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    miRNA metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of glial cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of TOR signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell proliferation involved in kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neuron differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of production of miRNAs involved in gene silencing by miRNA IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein kinase B signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    pre-miRNA processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    pre-miRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    pre-miRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of gene silencing by miRNA IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    P-body ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    rough endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    protein lin-28 homolog A
    Names
    RNA-binding protein LIN-28
    testis expressed gene 17
    testis-expressed protein 17

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145833.1NP_665832.1  protein lin-28 homolog A

      See identical proteins and their annotated locations for NP_665832.1

      Status: PROVISIONAL

      Source sequence(s)
      AF521097
      Consensus CDS
      CCDS18761.1
      UniProtKB/Swiss-Prot
      Q8K3Y3
      Related
      ENSMUSP00000050488.2, OTTMUSP00000010858, ENSMUST00000051674.2, OTTMUST00000023733
      Conserved Domains (1) summary
      cd04458
      Location:42111
      CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      134003330..134019202 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011250361.2XP_011248663.1  protein lin-28 homolog A isoform X2

      Conserved Domains (1) summary
      cd04458
      Location:261
      CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...
    2. XM_006539317.3XP_006539380.1  protein lin-28 homolog A isoform X1

      Conserved Domains (1) summary
      cl09927
      Location:6096
      S1_like; S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain. ...
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