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    Triobp TRIO and F-actin binding protein [ Mus musculus (house mouse) ]

    Gene ID: 110253, updated on 25-May-2017
    Official Symbol
    Triobpprovided by MGI
    Official Full Name
    TRIO and F-actin binding proteinprovided by MGI
    Primary source
    MGI:MGI:1349410
    See related
    Ensembl:ENSMUSG00000033088 Vega:OTTMUSG00000023632
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tara; AI428493; EST478828; mKIAA1662
    Summary
    This gene encodes a protein that interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility, and cell growth. The encoded protein also associates with F-actin and stabilizes F-actin structures. Domains contained in this encoded protein are an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. Mutations in the human gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants have been described [provided by RefSeq, Sep 2012]
    Orthologs
    Location:
    15 E1; 15 37.7 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (78947724..79005869)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (78778154..78836299)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 30368 Neighboring gene lectin, galactose binding, soluble 1 Neighboring gene nucleolar protein 12 Neighboring gene predicted gene 10865 Neighboring gene microRNA 6956 Neighboring gene predicted gene, 17753 Neighboring gene H1 histone family, member 0

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    actin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of substrate adhesion-dependent cell spreading IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    TRIO and F-actin-binding protein
    Names
    protein Tara
    trio-associated repeat on actin

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024716.1NP_001019887.1  TRIO and F-actin-binding protein isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) contains a distinct 5' UTR and 5' coding region, which causes translation initiation to occur at a downstream start codon, compared to variant 3. The encoded protein (isoform 1) has a shorter N-terminus when compared to isoform 3.
      Source sequence(s)
      AK085512, BX528408, BY199415, BY761337
      Consensus CDS
      CCDS37138.1
      UniProtKB/TrEMBL
      E9QMQ3
      Related
      ENSMUSP00000105310.1, ENSMUST00000109688.7
      Conserved Domains (3) summary
      cd13275
      Location:56157
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      pfam00169
      Location:56149
      PH; PH domain
      cl12013
      Location:380519
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    2. NM_001039155.1NP_001034244.1  TRIO and F-actin-binding protein isoform 4

      See identical proteins and their annotated locations for NP_001034244.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains a distinct 3' UTR and lacks a portion of the 3' coding region, compared to variant 3. The resulting isoform (4) has a shorter C-terminus when compared to isoform 3.
      Source sequence(s)
      DQ228002
      UniProtKB/Swiss-Prot
      Q99KW3
      Conserved Domains (2) summary
      PHA03247
      Location:378895
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:145515
      PHA03307; transcriptional regulator ICP4; Provisional
    3. NM_001039156.1NP_001034245.1  TRIO and F-actin-binding protein isoform 3

      See identical proteins and their annotated locations for NP_001034245.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) encodes the longest protein (isoform 3).
      Source sequence(s)
      BP768417, CX223548, DQ228000
      Consensus CDS
      CCDS37136.1
      UniProtKB/Swiss-Prot
      Q99KW3
      Related
      ENSMUSP00000105312.3, OTTMUSP00000027844, ENSMUST00000109690.9, OTTMUST00000057683
      Conserved Domains (5) summary
      cd13275
      Location:14431544
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      pfam00169
      Location:14431536
      PH; PH domain
      pfam15665
      Location:17721989
      FAM184; Family with sequence similarity 184, A and B
      cl12013
      Location:17671906
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl23720
      Location:18801996
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    4. NM_138579.4NP_613045.3  TRIO and F-actin-binding protein isoform 5

      See identical proteins and their annotated locations for NP_613045.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an in-frame exon, compared to variant 3, resulting in a shorter protein (isoform 5) when compared to isoform 3.
      Source sequence(s)
      BP768417, BU058377, CA322031, CA751843, CF531000, CF532339, CF533172, CN528900, CX223548, DQ278602
      Consensus CDS
      CCDS37137.1
      UniProtKB/Swiss-Prot
      Q99KW3
      Related
      ENSMUSP00000105311.2, OTTMUSP00000027845, ENSMUST00000109689.8, OTTMUST00000057684
      Conserved Domains (5) summary
      cd13275
      Location:13971498
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      pfam00169
      Location:13971490
      PH; PH domain
      pfam15665
      Location:17261943
      FAM184; Family with sequence similarity 184, A and B
      cl12013
      Location:17211860
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl23720
      Location:18341950
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

      Range
      78947724..79005869
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520284.1XP_006520347.1  TRIO and F-actin-binding protein isoform X1

      See identical proteins and their annotated locations for XP_006520347.1

      Conserved Domains (5) summary
      cd13275
      Location:14441545
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      pfam00169
      Location:14441537
      PH; PH domain
      pfam15665
      Location:17731990
      FAM184; Family with sequence similarity 184, A and B
      cl12013
      Location:17681907
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl23720
      Location:18811997
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    2. XM_006520286.1XP_006520349.1  TRIO and F-actin-binding protein isoform X3

      Conserved Domains (5) summary
      cd13275
      Location:13981499
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      pfam00169
      Location:13981491
      PH; PH domain
      pfam15665
      Location:17271944
      FAM184; Family with sequence similarity 184, A and B
      cl12013
      Location:17221861
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl23720
      Location:18351951
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    3. XM_006520287.1XP_006520350.1  TRIO and F-actin-binding protein isoform X4

      Conserved Domains (5) summary
      cd13275
      Location:13721473
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      pfam00169
      Location:13721465
      PH; PH domain
      pfam15665
      Location:17011918
      FAM184; Family with sequence similarity 184, A and B
      cl12013
      Location:16961835
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl23720
      Location:18091925
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    4. XM_006520288.2XP_006520351.1  TRIO and F-actin-binding protein isoform X5

      Conserved Domains (2) summary
      cd13275
      Location:14441545
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      pfam00169
      Location:14441537
      PH; PH domain
    5. XM_006520285.1XP_006520348.1  TRIO and F-actin-binding protein isoform X1

      See identical proteins and their annotated locations for XP_006520348.1

      Conserved Domains (5) summary
      cd13275
      Location:14441545
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      pfam00169
      Location:14441537
      PH; PH domain
      pfam15665
      Location:17731990
      FAM184; Family with sequence similarity 184, A and B
      cl12013
      Location:17681907
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl23720
      Location:18811997
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    6. XM_017316365.1XP_017171854.1  TRIO and F-actin-binding protein isoform X2

      UniProtKB/Swiss-Prot
      Q99KW3
      Conserved Domains (5) summary
      cd13275
      Location:14431544
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      pfam00169
      Location:14431536
      PH; PH domain
      pfam15665
      Location:17721989
      FAM184; Family with sequence similarity 184, A and B
      cl12013
      Location:17671906
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl23720
      Location:18801996
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    7. XM_006520289.2XP_006520352.1  TRIO and F-actin-binding protein isoform X6

      Conserved Domains (4) summary
      cd13275
      Location:93194
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      pfam00169
      Location:93186
      PH; PH domain
      cl12013
      Location:417556
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl23720
      Location:530646
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    8. XM_006520291.2XP_006520354.1  TRIO and F-actin-binding protein isoform X7

      Related
      ENSMUSP00000122988.2, OTTMUSP00000027873, ENSMUST00000130663.8, OTTMUST00000057718
      Conserved Domains (2) summary
      cd13275
      Location:56157
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      pfam00169
      Location:56149
      PH; PH domain
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