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    Fosb FBJ osteosarcoma oncogene B [ Mus musculus (house mouse) ]

    Gene ID: 14282, updated on 16-Jul-2017
    Official Symbol
    Fosbprovided by MGI
    Official Full Name
    FBJ osteosarcoma oncogene Bprovided by MGI
    Primary source
    MGI:MGI:95575
    See related
    Ensembl:ENSMUSG00000003545 Vega:OTTMUSG00000059145
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Orthologs
    Location:
    7 A3; 7 9.56 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (19302696..19310226, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (19888045..19895394, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene reticulon 2 (Z-band associated protein) Neighboring gene predicted gene, 26802 Neighboring gene excision repair cross-complementing rodent repair deficiency, complementation group 1 Neighboring gene CD3E antigen, epsilon polypeptide associated protein Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 13 like

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Alcoholism, organism-specific biosystem (from KEGG)
      Alcoholism, organism-specific biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
    • Alcoholism, conserved biosystem (from KEGG)
      Alcoholism, conserved biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
    • Amphetamine addiction, organism-specific biosystem (from KEGG)
      Amphetamine addiction, organism-specific biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
    • Amphetamine addiction, conserved biosystem (from KEGG)
      Amphetamine addiction, conserved biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
    • Cocaine addiction, organism-specific biosystem (from KEGG)
      Cocaine addiction, organism-specific biosystemDrug addiction is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behavior persists despite serious negative consequences.There is strong evidence that the dopaminergic...
    • Cocaine addiction, conserved biosystem (from KEGG)
      Cocaine addiction, conserved biosystemDrug addiction is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behavior persists despite serious negative consequences.There is strong evidence that the dopaminergic...
    • IL-17 signaling pathway, organism-specific biosystem (from KEGG)
      IL-17 signaling pathway, organism-specific biosystemThe interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial roles in both acute and chronic inflammatory responses. IL-17A, the hallmark cytokine of the newly defi...
    • IL-17 signaling pathway, conserved biosystem (from KEGG)
      IL-17 signaling pathway, conserved biosystemThe interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial roles in both acute and chronic inflammatory responses. IL-17A, the hallmark cytokine of the newly defi...
    • Osteoclast differentiation, organism-specific biosystem (from KEGG)
      Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • Osteoclast differentiation, conserved biosystem (from KEGG)
      Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    protein fosB
    Names
    osteosarcoma oncoprotein B FosB

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347586.1NP_001334515.1  protein fosB isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region which results in a frameshift, compared to variant 1. This difference results in a protein (isoform 2) with a shorter and distinct C-terminus, compared to isoform 1
      Source sequence(s)
      AC148988, AI846927, BC145082
      Consensus CDS
      CCDS85225.1
      UniProtKB/TrEMBL
      A0A140LIE4
    2. NM_008036.2NP_032062.1  protein fosB isoform 1

      See identical proteins and their annotated locations for NP_032062.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC148988, AI846927, BU698478, BY337108, BY547195, CF356426, CK795975
      Consensus CDS
      CCDS20897.1
      UniProtKB/Swiss-Prot
      P13346
      UniProtKB/TrEMBL
      A2RSD4
      Related
      ENSMUSP00000003640.2, OTTMUSP00000075582, ENSMUST00000003640.3, OTTMUST00000145066
      Conserved Domains (1) summary
      cd14721
      Location:165218
      bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      19302696..19310226 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539543.2XP_006539606.1  protein fosB isoform X1

      See identical proteins and their annotated locations for XP_006539606.1

      UniProtKB/Swiss-Prot
      P13346
      UniProtKB/TrEMBL
      A2RSD4
      Conserved Domains (1) summary
      cd14721
      Location:165218
      bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain
    2. XM_006539544.3XP_006539607.1  protein fosB isoform X2

      Related
      ENSMUSP00000146789.1, OTTMUSP00000075597, ENSMUST00000208446.1, OTTMUST00000145100
      Conserved Domains (1) summary
      cd14721
      Location:165218
      bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain
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