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    Lrp4 low density lipoprotein receptor-related protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 228357, updated on 22-Apr-2017
    Official Symbol
    Lrp4provided by MGI
    Official Full Name
    low density lipoprotein receptor-related protein 4provided by MGI
    Primary source
    MGI:MGI:2442252
    See related
    Ensembl:ENSMUSG00000027253 Vega:OTTMUSG00000014247
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mdig; Megf7; D230026E03; 6430526J12Rik
    Orthologs
    Location:
    2 E1; 2 50.63 cM
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (91457471..91513901)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (91297688..91354058)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1110051M20 gene Neighboring gene ADP-ribosylation factor GTPase activating protein 2 Neighboring gene predicted gene 13787 Neighboring gene predicted gene 13770 Neighboring gene cytoskeleton associated protein 5 Neighboring gene small nucleolar RNA, C/D box 67

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    Wnt-activated receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Wnt-protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    apolipoprotein binding ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    receptor tyrosine kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Wnt signaling pathway involved in dorsal/ventral axis specification IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    anatomical structure development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    animal organ development IEA
    Inferred from Electronic Annotation
    more info
     
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    dorsal/ventral pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic digit morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic limb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    hair follicle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    kidney development ISO
    Inferred from Sequence Orthology
    more info
     
    limb development ISO
    Inferred from Sequence Orthology
    more info
     
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of ossification ISO
    Inferred from Sequence Orthology
    more info
     
    odontogenesis of dentin-containing tooth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of peptidyl-tyrosine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of presynaptic membrane organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of skeletal muscle acetylcholine-gated channel clustering IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    postsynaptic membrane assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    presynaptic membrane assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein heterotetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    proximal/distal pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    receptor clustering IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    skeletal muscle acetylcholine-gated channel clustering IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    synapse organization ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic growth at neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptic growth at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with flotillin complex ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    neuromuscular junction IC
    Inferred by Curator
    more info
    PubMed 
    neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    synaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    low-density lipoprotein receptor-related protein 4
    Names
    LDLR dan
    LRP-4

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145857.1NP_001139329.1  low-density lipoprotein receptor-related protein 4 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001139329.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK032360, BC132240, BY753111
      UniProtKB/Swiss-Prot
      Q8VI56
      Conserved Domains (5) summary
      smart00135
      Location:460502
      LY; Low-density lipoprotein-receptor YWTD domain
      cd00112
      Location:270304
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:70105
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam14670
      Location:358393
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl00057
      Location:390432
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    2. NM_172668.3NP_766256.3  low-density lipoprotein receptor-related protein 4 isoform 1 precursor

      See identical proteins and their annotated locations for NP_766256.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AF247637, AL691489, BC132240, BY753111, CN533524
      Consensus CDS
      CCDS16432.1
      UniProtKB/Swiss-Prot
      Q8VI56
      Related
      ENSMUSP00000028689.3, OTTMUSP00000015050, ENSMUST00000028689.3, OTTMUST00000033533
      Conserved Domains (9) summary
      smart00192
      Location:311343
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:505545
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:395434
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:270304
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd05819
      Location:10851123
      NHL; NHL repeat [structural motif]
      pfam00057
      Location:70105
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:14831523
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:13131348
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl18310
      Location:10851277
      NHL; NHL repeat unit of beta-propeller proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      91457471..91513901
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499243.3XP_006499306.1  low-density lipoprotein receptor-related protein 4 isoform X1

      Conserved Domains (9) summary
      smart00192
      Location:311343
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:505545
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:395434
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:270304
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd05819
      Location:10851123
      NHL; NHL repeat [structural motif]
      pfam00057
      Location:70105
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:14831523
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:13131348
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl18310
      Location:10851277
      NHL; NHL repeat unit of beta-propeller proteins

    RNA

    1. XR_374447.3 RNA Sequence

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