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    HTS1 histidine--tRNA ligase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856145, updated on 5-Nov-2017
    Gene symbol
    HTS1
    Gene description
    histidine--tRNA ligase
    Primary source
    SGD:S000006237
    Locus tag
    YPR033C
    Gene type
    protein coding
    RNA name
    histidine--tRNA ligase
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    TS4572; TSM4572
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (637379..639019, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Nto1p Neighboring gene Rab GTPase-binding protein SRO7 Neighboring gene Arp7p Neighboring gene glutamate--ammonia ligase

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    aminoacyl-tRNA ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    histidine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    histidyl-tRNA aminoacylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histidyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
     
    histidyl-tRNA aminoacylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrial translation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    translation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Names
    histidine--tRNA ligase
    NP_015358.1
    • Cytoplasmic and mitochondrial histidine tRNA synthetase; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence; mutations in human ortholog HARS2 are associated with Perrault syndrome

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      637379..639019 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184130.1NP_015358.1  TPA: histidine--tRNA ligase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015358.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P07263
      Conserved Domains (3) summary
      COG0124
      Location:54529
      HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
      cd00773
      Location:68412
      HisRS-like_core; Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...
      cd00859
      Location:425525
      HisRS_anticodon; HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...
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