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    Ccr2 chemokine (C-C motif) receptor 2 [ Mus musculus (house mouse) ]

    Gene ID: 12772, updated on 14-Apr-2018
    Official Symbol
    Ccr2provided by MGI
    Official Full Name
    chemokine (C-C motif) receptor 2provided by MGI
    Primary source
    MGI:MGI:106185
    See related
    Ensembl:ENSMUSG00000049103 Vega:OTTMUSG00000035281
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ckr2; Ccr2a; Ccr2b; Ckr2a; Ckr2b; mJe-r; Cmkbr2; Cc-ckr-2
    Expression
    Broad expression in bladder adult (RPKM 3.5), mammary gland adult (RPKM 3.2) and 17 other tissues See more
    Orthologs
    Location:
    9 F4; 9 75.05 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (124101918..124109140)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (124016922..124023879)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene chemokine (C-C motif) receptor 1-like 1 Neighboring gene chemokine (C-C motif) receptor 3 Neighboring gene chemokine (C-C motif) receptor 5 Neighboring gene predicted gene, 39469

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    C-C chemokine receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    G-protein coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    chemokine (C-C motif) ligand 12 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    chemokine (C-C motif) ligand 2 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    chemokine (C-C motif) ligand 7 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    chemokine receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    cytokine binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    signal transducer activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    T-helper 17 cell chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    angiogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    apoptotic cell clearance IC
    Inferred by Curator
    more info
    PubMed 
    blood vessel remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    cellular defense response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    cytokine-mediated signaling pathway ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    homeostasis of number of cells within a tissue IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    humoral immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    leukocyte adhesion to vascular endothelial cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    monocyte chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of eosinophil degranulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of type 2 immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neutrophil clearance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of CD8-positive, alpha-beta T cell extravasation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of T cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of T cell chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of T-helper 1 cell differentiation IC
    Inferred by Curator
    more info
    PubMed 
    positive regulation of T-helper 1 type immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of alpha-beta T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of astrocyte chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of hematopoietic stem cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of immune complex clearance by monocytes and macrophages IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of inflammatory response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of interferon-gamma production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interleukin-2 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of leukocyte tethering or rolling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of monocyte chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of monocyte chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of monocyte extravasation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of tumor necrosis factor biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of vascular endothelial growth factor production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    wound healing involved in inflammatory response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    C-C chemokine receptor type 2
    Names
    C-C CHEMOKINE RECEPTOR TYPE 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (JE/FIC RECEPTOR) (MCP-1 RECEPTOR)
    C-C CKR-2
    CCR-2
    JE/FIC receptor
    MCP-1 receptor
    MIP-1 alphaR
    chemoattractant protein-1 receptor
    chemokine (C-C) receptor 2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009915.2NP_034045.1  C-C chemokine receptor type 2

      See identical proteins and their annotated locations for NP_034045.1

      Status: VALIDATED

      Source sequence(s)
      AK138599, AK162705, U56819
      Consensus CDS
      CCDS23669.1
      UniProtKB/Swiss-Prot
      P51683
      UniProtKB/TrEMBL
      Q3TRK1, Q543S8
      Related
      ENSMUSP00000049909.6, OTTMUSP00000049244, ENSMUST00000055918.6, OTTMUST00000089982
      Conserved Domains (2) summary
      PHA03087
      Location:20325
      PHA03087; G protein-coupled chemokine receptor-like protein; Provisional
      cl21561
      Location:67191
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      124101918..124109140
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243063.1XP_011241365.1  C-C chemokine receptor type 2 isoform X1

      See identical proteins and their annotated locations for XP_011241365.1

      UniProtKB/Swiss-Prot
      P51683
      UniProtKB/TrEMBL
      Q543S8
      Conserved Domains (2) summary
      PHA03087
      Location:20325
      PHA03087; G protein-coupled chemokine receptor-like protein; Provisional
      cl21561
      Location:67191
      7tm_4; Olfactory receptor
    2. XM_011243064.2XP_011241366.1  C-C chemokine receptor type 2 isoform X1

      See identical proteins and their annotated locations for XP_011241366.1

      UniProtKB/Swiss-Prot
      P51683
      UniProtKB/TrEMBL
      Q543S8
      Related
      ENSMUSP00000132453.1, OTTMUSP00000049242, ENSMUST00000168841.2, OTTMUST00000089980
      Conserved Domains (2) summary
      PHA03087
      Location:20325
      PHA03087; G protein-coupled chemokine receptor-like protein; Provisional
      cl21561
      Location:67191
      7tm_4; Olfactory receptor
    3. XM_006512428.2XP_006512491.1  C-C chemokine receptor type 2 isoform X1

      See identical proteins and their annotated locations for XP_006512491.1

      UniProtKB/Swiss-Prot
      P51683
      UniProtKB/TrEMBL
      Q543S8
      Conserved Domains (2) summary
      PHA03087
      Location:20325
      PHA03087; G protein-coupled chemokine receptor-like protein; Provisional
      cl21561
      Location:67191
      7tm_4; Olfactory receptor
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