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    Slc25a4 solute carrier family 25 member 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 85333, updated on 8-Apr-2018
    Official Symbol
    Slc25a4provided by RGD
    Official Full Name
    solute carrier family 25 member 4provided by RGD
    Primary source
    RGD:620352
    See related
    Ensembl:ENSRNOG00000010830
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ant1
    Summary
    catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane [RGD, Feb 2006]
    Expression
    Biased expression in Heart (RPKM 24226.4), Muscle (RPKM 22345.4) and 3 other tissues See more
    Orthologs
    Location:
    16q11
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (49266903..49270698)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 16 NC_005115.3 (48981600..48985395)

    Chromosome 16 - NC_005115.4Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene helt bHLH transcription factor Neighboring gene cilia and flagella associated protein 97 Neighboring gene sorting nexin 25 Neighboring gene Lrp2 binding protein Neighboring gene ankyrin repeat domain 37

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Calcium signaling pathway, organism-specific biosystem (from KEGG)
      Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Calcium signaling pathway, conserved biosystem (from KEGG)
      Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Electron Transport Chain, organism-specific biosystem (from WikiPathways)
      Electron Transport Chain, organism-specific biosystemAn electron transport chain(ETC) couples a chemical reaction between an electron donor (such as NADH) and an electron acceptor (such as O2) to the transfer of H+ ions across a membrane, through a set...
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Huntington's disease, organism-specific biosystem (from KEGG)
      Huntington's disease, organism-specific biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
    • Huntington's disease, conserved biosystem (from KEGG)
      Huntington's disease, conserved biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
    • Integration of energy metabolism, organism-specific biosystem (from REACTOME)
      Integration of energy metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Parkinson's disease, organism-specific biosystem (from KEGG)
      Parkinson's disease, organism-specific biosystemParkinson's disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Mutations...
    • Regulation of insulin secretion, organism-specific biosystem (from REACTOME)
      Regulation of insulin secretion, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • cGMP-PKG signaling pathway, organism-specific biosystem (from KEGG)
      cGMP-PKG signaling pathway, organism-specific biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
    • cGMP-PKG signaling pathway, conserved biosystem (from KEGG)
      cGMP-PKG signaling pathway, conserved biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    ATP:ADP antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    ADP transport IEA
    Inferred from Electronic Annotation
    more info
     
    ADP transport ISO
    Inferred from Sequence Orthology
    more info
     
    ADP transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    ATP transport IEA
    Inferred from Electronic Annotation
    more info
     
    aging IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    apoptotic mitochondrial changes IEA
    Inferred from Electronic Annotation
    more info
     
    apoptotic mitochondrial changes ISO
    Inferred from Sequence Orthology
    more info
     
    heart development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    liver development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    mitochondrial transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of cardiac muscle cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of mitochondrial membrane permeability involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of necroptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of necroptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell growth involved in cardiac muscle cell development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of oxidative phosphorylation uncoupler activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to interleukin-1 IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    integral component of membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of mitochondrial membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    myelin sheath IEA
    Inferred from Electronic Annotation
    more info
     
    myelin sheath ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    ADP/ATP translocase 1
    Names
    ADP,ATP carrier protein 1
    ANT 1
    adenine nucleotide translocator 1
    adenine nucleotide translocator), member 4
    mitochondrial adenine nucleotide translocator
    solute carrier family 25 (mitochondrial adenine nucleotide translocator) member 4
    solute carrier family 25 (mitochondrial carrier
    solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053515.1NP_445967.1  ADP/ATP translocase 1

      See identical proteins and their annotated locations for NP_445967.1

      Status: PROVISIONAL

      Source sequence(s)
      X61667
      UniProtKB/Swiss-Prot
      Q05962
      Related
      ENSRNOP00000014704.2, ENSRNOT00000014704.4
      Conserved Domains (2) summary
      PTZ00169
      Location:2298
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:6101
      Mito_carr; Mitochondrial carrier protein

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005115.4 Reference Rnor_6.0 Primary Assembly

      Range
      49266903..49270698
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000084.1 Alternate Rn_Celera

      Range
      44072219..44076014
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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